Effects of
Animals
Antioxidants
/ pharmacology
Catalase
/ metabolism
Diabetes Mellitus, Experimental
/ drug therapy
Glutathione
/ metabolism
Glutathione Peroxidase
/ metabolism
Hypericum
/ chemistry
Male
Oils, Volatile
/ pharmacology
Oxidative Stress
Rats
Rats, Sprague-Dawley
Rats, Wistar
Streptozocin
Superoxide Dismutase
/ metabolism
Wound Healing
Antioxidant
Hypericum scabrum L.
diabetes
essential oil
wound
Journal
Cutaneous and ocular toxicology
ISSN: 1556-9535
Titre abrégé: Cutan Ocul Toxicol
Pays: England
ID NLM: 101266892
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
pubmed:
5
4
2022
medline:
6
7
2022
entrez:
4
4
2022
Statut:
ppublish
Résumé
The purpose of this study was to see if the essential oil of In the study, 63 Sprague-Dawley male rats weighing 250-300 g were divided into nine groups, each with seven rats (major groups: control group, diabetes group, and treatment group). For diabetes and treatment groups, streptozotocin (STZ) was given in a single dose of 60 mg/kg/i.p. In 7 days, the animals with diabetes (blood glucose level > 250 mg/dL) will be assigned to wound groups. All of the rats had circular full-thickness incisions in their dorsal skin caused by a 5 mm punch biopsy tool. The rats were slaughtered, blood was obtained, and their forwound tissues were dissected on the 3rd, 10th, and 14th post-wounding days. The levels of malondialdehyde (MDA) and glutathione (GSH), as well as the activities of glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) in plasma and wound tissues, were all measured. While GSH level, GPx, SOD, and CAT activities were decreased in the plasma and wound tissues, MDA level increased in the diabetic group as compared to the control group. When compared to the diabetes group, GSH level, GPx, SOD, and CAT activities were increased in the Since no information was found in the literature search, future work would focus on new research examining
Sections du résumé
BACKGROUND
UNASSIGNED
The purpose of this study was to see if the essential oil of
METHODS
UNASSIGNED
In the study, 63 Sprague-Dawley male rats weighing 250-300 g were divided into nine groups, each with seven rats (major groups: control group, diabetes group, and treatment group). For diabetes and treatment groups, streptozotocin (STZ) was given in a single dose of 60 mg/kg/i.p. In 7 days, the animals with diabetes (blood glucose level > 250 mg/dL) will be assigned to wound groups. All of the rats had circular full-thickness incisions in their dorsal skin caused by a 5 mm punch biopsy tool. The rats were slaughtered, blood was obtained, and their forwound tissues were dissected on the 3rd, 10th, and 14th post-wounding days. The levels of malondialdehyde (MDA) and glutathione (GSH), as well as the activities of glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) in plasma and wound tissues, were all measured.
RESULTS
UNASSIGNED
While GSH level, GPx, SOD, and CAT activities were decreased in the plasma and wound tissues, MDA level increased in the diabetic group as compared to the control group. When compared to the diabetes group, GSH level, GPx, SOD, and CAT activities were increased in the
CONCLUSION
UNASSIGNED
Since no information was found in the literature search, future work would focus on new research examining
Identifiants
pubmed: 35373654
doi: 10.1080/15569527.2022.2052890
doi:
Substances chimiques
Antioxidants
0
Oils, Volatile
0
Streptozocin
5W494URQ81
Catalase
EC 1.11.1.6
Glutathione Peroxidase
EC 1.11.1.9
Superoxide Dismutase
EC 1.15.1.1
Glutathione
GAN16C9B8O
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM