Cytology interpretation after a change to HPV testing in primary cervical screening: Observational study from the English pilot.
cytology
mass screening
papillomavirus infections
uterine cervical neoplasms
Journal
Cancer cytopathology
ISSN: 1934-6638
Titre abrégé: Cancer Cytopathol
Pays: United States
ID NLM: 101499453
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
revised:
23
02
2022
received:
24
01
2022
accepted:
03
03
2022
pubmed:
5
4
2022
medline:
8
7
2022
entrez:
4
4
2022
Statut:
ppublish
Résumé
Overcalling of abnormalities has been a concern for using cytology triage after positive high-risk human papillomavirus (HPV) tests in cervical screening. The authors studied the detection of cytological and histological abnormalities at age 24 to 64 years, using data from the English HPV pilot. The pilot compared routine implementation of primary cervical screening based on cytology (N = 931,539), where HPV test results were not available before cytology reporting, with that based on HPV testing (N = 403,269), where cytology was only required after positive HPV tests. Revealed HPV positivity was associated with a higher direct referral to colposcopy after any abnormality (adjusted odds ratio [OR Quality-controlled cervical screening programs can avoid inappropriate overgrading of HPV-positive cytology.
Sections du résumé
BACKGROUND
Overcalling of abnormalities has been a concern for using cytology triage after positive high-risk human papillomavirus (HPV) tests in cervical screening.
METHODS
The authors studied the detection of cytological and histological abnormalities at age 24 to 64 years, using data from the English HPV pilot. The pilot compared routine implementation of primary cervical screening based on cytology (N = 931,539), where HPV test results were not available before cytology reporting, with that based on HPV testing (N = 403,269), where cytology was only required after positive HPV tests.
RESULTS
Revealed HPV positivity was associated with a higher direct referral to colposcopy after any abnormality (adjusted odds ratio [OR
CONCLUSIONS
Quality-controlled cervical screening programs can avoid inappropriate overgrading of HPV-positive cytology.
Identifiants
pubmed: 35377967
doi: 10.1002/cncy.22572
pmc: PMC9542289
doi:
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
531-541Subventions
Organisme : Public Health England
ID : ODR1718_428
Organisme : Cancer Research UK
ID : C8162/A27047
Pays : United Kingdom
Investigateurs
Tracey-Louise Appleyard
(TL)
Margaret Cruickshank
(M)
Kate Cuschieri
(K)
Kay Ellis
(K)
Chris Evans
(C)
Viki Frew
(V)
Thomas Giles
(T)
Alastair Gray
(A)
Miles Holbrook
(M)
Katherine Hunt
(K)
Henry Kitchener
(H)
Tanya Levine
(T)
Emily McBride
(E)
David Mesher
(D)
Timothy Palmer
(T)
Janet Parker
(J)
Elizabeth Rimmer
(E)
Hazel Rudge Pickard
(H)
Alexandra Sargent
(A)
David Smith
(D)
John Smith
(J)
Kate Soldan
(K)
Ruth Stubbs
(R)
John Tidy
(J)
Xenia Tyler
(X)
Jo Waller
(J)
Informations de copyright
© 2022 The Authors. Cancer Cytopathology published by Wiley Periodicals LLC on behalf of American Cancer Society.
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