Disclosing the antitumour potential of the marine bromoditerpene sphaerococcenol A on distinct cancer cellular models.

Antineoplastic Agents / pharmacology Apoptosis Caco-2 Cells Caspase 9 Cell Line, Tumor Colorectal Neoplasms DNA Diterpenes Humans Hydrogen Peroxide / pharmacology
Algae Apoptosis Cancer stem cells Marine natural products Oxidative stress Proteasome

Journal

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295

Informations de publication

Date de publication:
May 2022
Historique:
received: 27 12 2021
revised: 22 03 2022
accepted: 23 03 2022
pubmed: 5 4 2022
medline: 28 4 2022
entrez: 4 4 2022
Statut: ppublish

Résumé

Nature has revealed to be a key source of innovative anticancer drugs. This study evaluated the antitumour potential of the marine bromoditerpene sphaerococcenol A on different cancer cellular models. Dose-response analyses (0.1-100 µM; 24 h) were accomplished in eight different tumour cell lines (A549, CACO-2, HCT-15, MCF-7, NCI-H226, PC-3, SH-SY5Y, SK-MEL-28). Deeper studies were conducted on MFC-7 cells, namely, determination of hydrogen peroxide (H

Identifiants

DOI: 10.1016/j.biopha.2022.112886 PMID: 35378501
pubmed: 35378501
pii: S0753-3322(22)00275-X
doi: 10.1016/j.biopha.2022.112886
pii:
doi:

Substances chimiques

Antineoplastic Agents 0
Diterpenes 0
sphaerococcenol A 0
DNA 9007-49-2
Hydrogen Peroxide BBX060AN9V
Caspase 9 EC 3.4.22.-

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

112886

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Auteurs

Celso Alves (C)

MARE-Marine and Environmental Sciences Centre, Politécnico de Leiria, 2520-630 Peniche, Portugal. Electronic address: celso.alves@ipleiria.pt.

Joana Silva (J)

MARE-Marine and Environmental Sciences Centre, Politécnico de Leiria, 2520-630 Peniche, Portugal.

Marta B Afonso (MB)

Research Institute for Medicines (iMed.ULisboa) Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisbon, Portugal.

Romina A Guedes (RA)

Research Institute for Medicines (iMed.ULisboa) Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisbon, Portugal.

Rita C Guedes (RC)

Research Institute for Medicines (iMed.ULisboa) Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisbon, Portugal.

Rebeca Alvariño (R)

Department of Pharmacology, Faculty of Veterinary, University of Santiago de Compostela, 27002 Lugo, Spain.

Susete Pinteus (S)

MARE-Marine and Environmental Sciences Centre, Politécnico de Leiria, 2520-630 Peniche, Portugal.

Helena Gaspar (H)

MARE-Marine and Environmental Sciences Centre, Politécnico de Leiria, 2520-630 Peniche, Portugal; BioISI - Biosystems and Integrative Sciences Institute Faculty of Science, University of Lisbon, 1749-016 Lisbon, Portugal.

Márcia I Goettert (MI)

Cell Culture Laboratory, Postgraduate Programme in Biotechnology, University of Vale do Taquari - Univates, Lajeado, RS 95914-014, Brazil.

Amparo Alfonso (A)

Department of Pharmacology, Faculty of Veterinary, University of Santiago de Compostela, 27002 Lugo, Spain.

Cecília M P Rodrigues (CMP)

Research Institute for Medicines (iMed.ULisboa) Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisbon, Portugal.

Maria C Alpoím (MC)

Center for Neuroscience and Cell Biology (CNC), University of Coimbra, 3004-517 Coimbra, Portugal.

Luis Botana (L)

Department of Pharmacology, Faculty of Veterinary, University of Santiago de Compostela, 27002 Lugo, Spain.

Rui Pedrosa (R)

MARE-Marine and Environmental Sciences Centre, ESTM, Politécnico de Leiria, 2520-614 Peniche, Portugal. Electronic address: rui.pedrosa@ipleiria.pt.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Disclosing the antitumour potential of the...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Disclosing the antitumour potential of the...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules Caco-2 › Disclosing the antitumour potential of the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines régulatrices de l'apoptose › Caspases › Caspases initiatrices › Caspase-9 › Disclosing the antitumour potential of the...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Disclosing the antitumour potential of the...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du rectum › Tumeurs colorectales › Disclosing the antitumour potential of the...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › Disclosing the antitumour potential of the...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Diterpènes › Disclosing the antitumour potential of the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Disclosing the antitumour potential of the...
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Peroxydes › Peroxyde d'hydrogène › Disclosing the antitumour potential of the...