Age-Independent Preoperative Chemosensitivity and 5-Year Outcome Determined by Combined 70- and 80-Gene Signature in a Prospective Trial in Early-Stage Breast Cancer.


Journal

Annals of surgical oncology
ISSN: 1534-4681
Titre abrégé: Ann Surg Oncol
Pays: United States
ID NLM: 9420840

Informations de publication

Date de publication:
04 Apr 2022
Historique:
received: 11 10 2021
accepted: 07 03 2022
entrez: 5 4 2022
pubmed: 6 4 2022
medline: 6 4 2022
Statut: aheadofprint

Résumé

The Neoadjuvant Breast Symphony Trial (NBRST) demonstrated the 70-gene risk of distant recurrence signature, MammaPrint, and the 80-gene molecular subtyping signature, BluePrint, precisely determined preoperative pathological complete response (pCR) in breast cancer patients. We report 5-year follow-up results in addition to an exploratory analysis by age and menopausal status. The observational, prospective NBRST (NCT01479101) included 954 early-stage breast cancer patients aged 18-90 years who received neoadjuvant chemotherapy and had clinical and genomic data available. Chemosensitivity and 5-year distant metastasis-free survival (DMFS) and overall survival (OS) were assessed. In a post hoc subanalysis, results were stratified by age (≤ 50 vs. > 50 years) and menopausal status in patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) tumors. MammaPrint and BluePrint further classified 23% of tumors to a different subtype compared with immunohistochemistry, with more precise correspondence to pCR rates. Five-year DMFS and OS were highest in MammaPrint Low Risk, Luminal A-type and HER2-type tumors, and lowest in MammaPrint High Risk, Luminal B-type and Basal-type tumors. There was no significant difference in chemosensitivity between younger and older patients with Low-Risk (2.2% vs. 3.8%; p = 0.64) or High-Risk tumors (14.5% vs. 11.5%; p = 0.42), or within each BluePrint subtype; this was similar when stratifying by menopausal status. The 5-year outcomes were comparable by age or menopausal status for each molecular subtype. Intrinsic preoperative chemosensitivity and long-term outcomes were precisely determined by BluePrint and MammaPrint regardless of patient age, supporting the utility of these assays to inform treatment and surgical decisions in early-stage breast cancer.

Sections du résumé

BACKGROUND BACKGROUND
The Neoadjuvant Breast Symphony Trial (NBRST) demonstrated the 70-gene risk of distant recurrence signature, MammaPrint, and the 80-gene molecular subtyping signature, BluePrint, precisely determined preoperative pathological complete response (pCR) in breast cancer patients. We report 5-year follow-up results in addition to an exploratory analysis by age and menopausal status.
METHODS METHODS
The observational, prospective NBRST (NCT01479101) included 954 early-stage breast cancer patients aged 18-90 years who received neoadjuvant chemotherapy and had clinical and genomic data available. Chemosensitivity and 5-year distant metastasis-free survival (DMFS) and overall survival (OS) were assessed. In a post hoc subanalysis, results were stratified by age (≤ 50 vs. > 50 years) and menopausal status in patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) tumors.
RESULTS RESULTS
MammaPrint and BluePrint further classified 23% of tumors to a different subtype compared with immunohistochemistry, with more precise correspondence to pCR rates. Five-year DMFS and OS were highest in MammaPrint Low Risk, Luminal A-type and HER2-type tumors, and lowest in MammaPrint High Risk, Luminal B-type and Basal-type tumors. There was no significant difference in chemosensitivity between younger and older patients with Low-Risk (2.2% vs. 3.8%; p = 0.64) or High-Risk tumors (14.5% vs. 11.5%; p = 0.42), or within each BluePrint subtype; this was similar when stratifying by menopausal status. The 5-year outcomes were comparable by age or menopausal status for each molecular subtype.
CONCLUSION CONCLUSIONS
Intrinsic preoperative chemosensitivity and long-term outcomes were precisely determined by BluePrint and MammaPrint regardless of patient age, supporting the utility of these assays to inform treatment and surgical decisions in early-stage breast cancer.

Identifiants

pubmed: 35378634
doi: 10.1245/s10434-022-11666-2
pii: 10.1245/s10434-022-11666-2
pmc: PMC9174138
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2022. The Author(s).

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Auteurs

Pat Whitworth (P)

Nashville Breast Center, Nashville, TN, USA.
Targeted Medical Education, Cupertino, CA, USA.

Peter D Beitsch (PD)

Targeted Medical Education, Cupertino, CA, USA.
Dallas Surgical Group, Dallas, TX, USA.

James V Pellicane (JV)

Bon Secours Cancer Institute, Richmond, VA, USA.

Paul L Baron (PL)

Breast and Melanoma Specialist of Charleston, Charleston, SC, USA.
Lenox Hill Hospital/Northwell Health, New York, NY, USA.

Laura A Lee (LA)

Comprehensive Cancer Center, Palm Springs, CA, USA.

Carrie L Dul (CL)

Ascension St. John Hospital Great Lakes Cancer Management Specialists, Grosse Pointe Woods, MI, USA.

Charles H Nash (CH)

Northeast Georgia Medical Center, Gainesville, GA, USA.

Mary K Murray (MK)

Akron General Medical Center, Akron, OH, USA.
Cleveland Clinic Akron General, Akron, OH, USA.

Paul D Richards (PD)

Blue Ridge Cancer Center, Roanoke, VA, USA.

Mark Gittleman (M)

Breast Care Specialists, Allentown, PA, USA.

Raye Budway (R)

St. Clair Hospital, Pittsburgh, PA, USA.

Rakhshanda Layeequr Rahman (RL)

Texas Tech University, Lubbock, TX, USA.

Pond Kelemen (P)

Ashikari Breast Center, Sleepy Hollow, NY, USA.
Zucker School of Medicine, Hofstra University, Hempstead, NY, USA.

William C Dooley (WC)

Breast Institute, University of Oklahoma Health Sciences, Oklahoma City, OK, USA.
Stephenson Cancer Center, Oklahoma City, OK, USA.

David T Rock (DT)

Regional Breast Care, Fort Myers, FL, USA.
Genesis Care, Fort Myers, FL, USA.

Ken Cowan (K)

University of Nebraska Medical Center, Omaha, NE, USA.

Beth-Ann Lesnikoski (BA)

The Breast Institute at JFK Medical Center, Atlantis, FL, USA.
Baptist MD Anderson Cancer Center, Jacksonville, FL, USA.

Julie L Barone (JL)

Exempla Saint Joseph Hospital, Denver, CO, USA.
Vail Health, Vail, CO, USA.

Andrew Y Ashikari (AY)

Ashikari Breast Center, Sleepy Hollow, NY, USA.
New York Medical College, Valhalla, NY, USA.
Northwell Health Physician Partners, Mount Kisco, NY, USA.
Phelps and Northern Westchester Hospitals, Westchester, NY, USA.

Beth Dupree (B)

St. Mary Medical Alliance Cancer Specialists, Langhorne, PA, USA.

Shiyu Wang (S)

Agendia Inc., Irvine, CA, USA.

Andrea R Menicucci (AR)

Agendia Inc., Irvine, CA, USA.

Erin B Yoder (EB)

Agendia Inc., Irvine, CA, USA.

Christine Finn (C)

Agendia Inc., Irvine, CA, USA.

Kate Corcoran (K)

Agendia Inc., Irvine, CA, USA.

Lisa E Blumencranz (LE)

Agendia Inc., Irvine, CA, USA.

William Audeh (W)

Agendia Inc., Irvine, CA, USA. william.audeh@agendia.com.

Classifications MeSH