Pharmacology Management in Improving Exercise Capacity of Patients with Fontan Circulation: A Systematic Review and Meta-analysis.

Bosentan / therapeutic use Exercise Test / methods Exercise Tolerance Fontan Procedure / methods Heart Defects, Congenital / surgery Humans Quality of Life Sildenafil Citrate / therapeutic use Sulfonamides / therapeutic use Treatment Outcome
Bosentan Fontan exercise capacity patients sildenafil vasodilator

Journal

Current cardiology reviews
ISSN: 1875-6557
Titre abrégé: Curr Cardiol Rev
Pays: United Arab Emirates
ID NLM: 101261935

Informations de publication

Date de publication:
2022
Historique:
received: 12 10 2021
revised: 15 02 2022
accepted: 21 02 2022
pubmed: 6 4 2022
medline: 24 9 2022
entrez: 5 4 2022
Statut: ppublish

Résumé

The Fontan procedure is currently the mainstay therapy for single functional ventricles. However, with prolonged follow-up duration, various complications have been observed that seriously influence the quality of life of patients. The aim of this meta-analysis is to compare the effectiveness of pharmacologic agents in improving exercise capacity in patients with Fontan circulation. This meta-analysis was conducted according to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) statement and has been registered in the International Prospective Register for Systematic Reviews database with registration no. 282352. Quality assessments of the included studies were assessed using the Strengthening Reporting of Observational Studies in Epidemiology (STROBE) statement. Twelve studies met the predetermined inclusion criteria and were included in this metaanalysis. This meta-analysis found that treatment with bosentan significantly improved New York Heart Association Functional Class (NYHA FC) in Fontan patients (standard mean difference - 0.59, 95% CI -0.94 - -0.25; P=0.0008; I This meta-analysis shows that people with Fontan circulation may benefit from using bosentan as it decreases postexercise heart rate and improves NYHA FC and 6-minute walking test results. Therefore, indirectly improving exercise capacity. Nonetheless, considerable work is required to strengthen our knowledge in improving the exercise capacity of Fontan patients.

Sections du résumé

BACKGROUND BACKGROUND
The Fontan procedure is currently the mainstay therapy for single functional ventricles. However, with prolonged follow-up duration, various complications have been observed that seriously influence the quality of life of patients.
OBJECTIVES OBJECTIVE
The aim of this meta-analysis is to compare the effectiveness of pharmacologic agents in improving exercise capacity in patients with Fontan circulation.
METHODS METHODS
This meta-analysis was conducted according to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) statement and has been registered in the International Prospective Register for Systematic Reviews database with registration no. 282352. Quality assessments of the included studies were assessed using the Strengthening Reporting of Observational Studies in Epidemiology (STROBE) statement.
RESULTS RESULTS
Twelve studies met the predetermined inclusion criteria and were included in this metaanalysis. This meta-analysis found that treatment with bosentan significantly improved New York Heart Association Functional Class (NYHA FC) in Fontan patients (standard mean difference - 0.59, 95% CI -0.94 - -0.25; P=0.0008; I
CONCLUSION CONCLUSIONS
This meta-analysis shows that people with Fontan circulation may benefit from using bosentan as it decreases postexercise heart rate and improves NYHA FC and 6-minute walking test results. Therefore, indirectly improving exercise capacity. Nonetheless, considerable work is required to strengthen our knowledge in improving the exercise capacity of Fontan patients.

Identifiants

DOI: 10.2174/1573403X18666220404101610 PMID: 35379155 PMC: PMC9896416
pubmed: 35379155
pii: CCR-EPUB-122222
doi: 10.2174/1573403X18666220404101610
pmc: PMC9896416
doi:

Substances chimiques

Sulfonamides 0
Sildenafil Citrate BW9B0ZE037
Bosentan Q326023R30

Types de publication

Meta-Analysis Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

34-49

Informations de copyright

Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Références

Eur J Cardiothorac Surg. 2006 Dec;30(6):923-9
pubmed: 17074498
Vasc Health Risk Manag. 2006;2(4):411-22
pubmed: 17323595
Circulation. 2004 Jun 29;109(25):3106-11
pubmed: 15226227
J Thorac Cardiovasc Surg. 2017 Jun;153(6):1468-1475
pubmed: 28283234
N Engl J Med. 2002 Mar 21;346(12):896-903
pubmed: 11907289
Ther Adv Respir Dis. 2017 Jun;11(6):233-244
pubmed: 28425346
Eur J Heart Fail. 2013 Jun;15(6):690-8
pubmed: 23361871
Eur J Cardiothorac Surg. 2009 Jul;36(1):57-62
pubmed: 19369086
Glob Cardiol Sci Pract. 2017 Jun 30;2017(2):14
pubmed: 29644226
Int J Cardiol. 2013 Oct 3;168(3):2435-40
pubmed: 23545150
N Engl J Med. 2005 Nov 17;353(20):2148-57
pubmed: 16291984
Int J Surg. 2014 Dec;12(12):1495-9
pubmed: 25046131
PLoS Med. 2009 Jul 21;6(7):e1000097
pubmed: 19621072
Vasc Health Risk Manag. 2007;3(6):887-900
pubmed: 18200808
Pediatr Cardiol. 2016 Mar;37(3):504-11
pubmed: 26547436
Am J Cardiol. 2016 May 1;117(9):1524-32
pubmed: 27063478
Anesth Analg. 1995 Nov;81(5):1052-9
pubmed: 7486046
Pediatr Cardiol. 2016 Jan;37(1):55-61
pubmed: 26215768
Clin Pharmacokinet. 2004;43(15):1089-115
pubmed: 15568889
Core Evid. 2015 Nov 02;10:99-109
pubmed: 26587013
Am J Respir Crit Care Med. 2002 Jul 1;166(1):111-7
pubmed: 12091180
Nat Clin Pract Cardiovasc Med. 2005 Apr;2(4):202-8
pubmed: 16265484
J Cardiovasc Med (Hagerstown). 2015 Aug;16(8):552-5
pubmed: 23588032
Expert Opin Pharmacother. 2009 Sep;10(13):2195-207
pubmed: 19663611
Eur J Cardiothorac Surg. 2007 Mar;31(3):344-52; discussion 353
pubmed: 17236782
J Huazhong Univ Sci Technolog Med Sci. 2016 Aug;36(4):534-540
pubmed: 27465329
Circulation. 1991 Jun;83(6):2038-47
pubmed: 2040056
Circulation. 2008 Jun 10;117(23):3010-9
pubmed: 18506008
Eur Heart J. 2008 Jul;29(13):1681-7
pubmed: 18534975
Korean J Anesthesiol. 2010 Jan;58(1):4-14
pubmed: 20498805
Cardiol Young. 2009 Aug;19(4):331-9
pubmed: 19519964
Clin Res Cardiol. 2014 Aug;103(8):641-6
pubmed: 24639042
Toxicol Sci. 2001 Jan;59(1):5-16
pubmed: 11134540
Circulation. 2011 Mar 22;123(11):1185-93
pubmed: 21382896
Eur Respir Rev. 2009 Mar;18(111):29-34
pubmed: 20956120
Heart. 2005 Jun;91(6):839-46
pubmed: 15894794
Int J Cardiol. 2016 Oct 15;221:122-7
pubmed: 27400308
Congenit Heart Dis. 2012 May-Jun;7(3):243-9
pubmed: 22348734
Congenit Heart Dis. 2015 Jan-Feb;10(1):E11-6
pubmed: 24890846
Br J Clin Pharmacol. 2006 Mar;61(3):280-8
pubmed: 16487221
Circulation. 1997 Sep 2;96(5):1507-12
pubmed: 9315539
Circ Cardiovasc Imaging. 2014 Mar;7(2):265-73
pubmed: 24478333
Circulation. 2014 Dec 2;130(23):2021-30
pubmed: 25446057
J Am Heart Assoc. 2019 May 7;8(9):e012008
pubmed: 31041880
Int J Cardiol. 2013 Aug 20;167(4):1311-6
pubmed: 22521378
BMC Pulm Med. 2017 Feb 23;17(1):44
pubmed: 28228114

Auteurs

Brian Mendel (B)

Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Department of Cardiology and Vascular Medicine, Pediatric Cardiology and Congenital Heart Defect Division, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia.
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.

Moira Setiawan (M)

Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.

Sisca Natalia Siagian (SN)

Department of Cardiology and Vascular Medicine, Pediatric Cardiology and Congenital Heart Defect Division, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia.

Radityo Prakoso (R)

Department of Cardiology and Vascular Medicine, Pediatric Cardiology and Congenital Heart Defect Division, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia.

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Bosentan › Pharmacology Management in Improving Exercise...
questionsmedicales.fr › Techniques d'investigation › Ergométrie › Épreuve d'effort › Pharmacology Management in Improving Exercise...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Tolérance à l'effort › Pharmacology Management in Improving Exercise...
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de chirurgie thoracique › Procédures de chirurgie cardiaque › Procédures de Norwood › Procédure de Fontan › Pharmacology Management in Improving Exercise...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Malformations › Malformations cardiovasculaires › Cardiopathies congénitales › Pharmacology Management in Improving Exercise...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Pharmacology Management in Improving Exercise...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Démographie › État de santé › Qualité de vie › Pharmacology Management in Improving Exercise...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Purines › Citrate de sildénafil › Pharmacology Management in Improving Exercise...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Sulfones › Sulfonamides › Pharmacology Management in Improving Exercise...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › Pharmacology Management in Improving Exercise...