Platelet transmission electron microscopy for the assessment of poor biological response to antiplatelet agent: pilot descriptive and prospective study - ELECTROSTROKE.
Stroke
Stroke medicine
Vascular medicine
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
04 04 2022
04 04 2022
Historique:
entrez:
5
4
2022
pubmed:
6
4
2022
medline:
7
4
2022
Statut:
epublish
Résumé
Ischaemic stroke is the leading cause of adult disability. Thus, a strategy based on an efficient antiplatelet therapy has been developed. The monitoring of antiplatelet therapy is now limited to high risk and poor prognosis patients. Indeed, the biological monitoring of the antiplatelet therapy with available platelet function assays do not provide a global integrative approach. Platelet transmission electron microscopy, recently validated for assessing distinct ultrastructural abnormalities is a reliable morphological platelet structural analysis tool which could be used to collect all the ultrastructural platelet characteristics and assess the degree of activation of platelets. Our pilot prospective and descriptive study will include 50 consecutive patients hospitalized for an ischaemic stroke. We expect to identify ultrastructural characteristics that will be correlated with the degree of platelet activation to guide clinicians in decision making regarding the antiplatelet therapy strategy. The French Ethics Committee (comité de protection des personnes d'Ile-de-France VII) approved the information notice that will be given to participants and the protocol of this trial (protocol No 21-031).The results of the trial will be disseminated through scientific publications. NCT05004233.
Identifiants
pubmed: 35379612
pii: bmjopen-2021-050060
doi: 10.1136/bmjopen-2021-050060
pmc: PMC8981285
doi:
Substances chimiques
Platelet Aggregation Inhibitors
0
Banques de données
ClinicalTrials.gov
['NCT05004233']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e050060Informations de copyright
© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
Am J Transl Res. 2019 Sep 15;11(9):5332-5337
pubmed: 31632514
J Am Coll Cardiol. 2012 Aug 14;60(7):645-81
pubmed: 22809746
J Am Coll Cardiol. 2011 Dec 6;58(24):e44-122
pubmed: 22070834
Stroke. 1985 Jul-Aug;16(4):643-7
pubmed: 3161220
Stroke. 2014 Jul;45(7):2160-236
pubmed: 24788967
Methods Mol Biol. 2004;272:47-63
pubmed: 15226533
G Ital Cardiol (Rome). 2013 Sep;14(9):559-63
pubmed: 23903274
J Thromb Haemost. 2010 Oct;8(10):2140-8
pubmed: 20723029
J Thromb Haemost. 2017 Aug;15(8):1655-1667
pubmed: 28561434
Bionanoscience. 2019 Mar;9(1):53-58
pubmed: 31534882
Rev Med Interne. 2010 Dec;31 Suppl 3:S319-23
pubmed: 21056518
Thromb Haemost. 2012 Mar;107(3):494-506
pubmed: 22273694
Platelets. 2020 Jul 3;31(5):580-588
pubmed: 32423268
Transfus Med Hemother. 2013 Apr;40(2):101-7
pubmed: 23652838
Platelets. 2018 Sep;29(6):574-582
pubmed: 29863946
J Thromb Haemost. 2016 Mar;14(3):572-84
pubmed: 26663480
Am Heart J. 2010 Sep;160(3):543-51
pubmed: 20826265
Bull Acad Natl Med. 2013 Feb;197(2):361-73
pubmed: 24919366
Thromb Res. 2004;113(3-4):197-204
pubmed: 15140583
Am J Transl Res. 2018 Aug 15;10(8):2712-2721
pubmed: 30210708
Lancet. 2016 Oct 22;388(10055):2015-2022
pubmed: 27581531
Eur Heart J. 2011 Dec;32(23):2999-3054
pubmed: 21873419
Stroke. 2004 Jul;35(7):1683-7
pubmed: 15155956
Neurology. 1998 Sep;51(3 Suppl 3):S9-14
pubmed: 9744824
Pract Lab Med. 2018 Feb 16;11:10-18
pubmed: 30202779
Eur Heart J. 2014 Jan;35(4):209-15
pubmed: 24067509