Mllt11 Regulates Migration and Neurite Outgrowth of Cortical Projection Neurons during Development.


Journal

The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140

Informations de publication

Date de publication:
11 05 2022
Historique:
received: 17 01 2022
revised: 13 03 2022
accepted: 30 03 2022
pubmed: 6 4 2022
medline: 18 5 2022
entrez: 5 4 2022
Statut: ppublish

Résumé

The formation of connections within the mammalian neocortex is highly regulated by both extracellular guidance mechanisms and intrinsic gene expression programs. There are two types of cortical projection neurons (CPNs): those that project locally and interhemispherically and those that project to subcerebral structures such as the thalamus, hindbrain, and spinal cord. The regulation of cortical projection morphologies is not yet fully understood at the molecular level. Here, we report a role for Mllt11 (Myeloid/lymphoid or mixed-lineage leukemia; translocated to chromosome 11/All1 Fused Gene From Chromosome 1q) in the migration and neurite outgrowth of callosal projection neurons during mouse brain formation. We show that

Identifiants

pubmed: 35379703
pii: JNEUROSCI.0124-22.2022
doi: 10.1523/JNEUROSCI.0124-22.2022
pmc: PMC9097781
doi:

Substances chimiques

MLLT11 protein, mouse 0
Proto-Oncogene Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

3931-3948

Subventions

Organisme : CIHR
ID : PJT-388914
Pays : Canada
Organisme : CIHR
ID : PJT-159738
Pays : Canada

Informations de copyright

Copyright © 2022 Stanton-Turcotte et al.

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Auteurs

Danielle Stanton-Turcotte (D)

Department of Medical Neuroscience, and Brain Repair Centre, Faculty of Medicine, Dalhousie University. Life Science Research Institute, Halifax, Nova Scotia B3H-4R2, Canada.

Karolynn Hsu (K)

Department of Medical Neuroscience, and Brain Repair Centre, Faculty of Medicine, Dalhousie University. Life Science Research Institute, Halifax, Nova Scotia B3H-4R2, Canada.

Samantha A Moore (SA)

Department of Medical Neuroscience, and Brain Repair Centre, Faculty of Medicine, Dalhousie University. Life Science Research Institute, Halifax, Nova Scotia B3H-4R2, Canada.

Makiko Yamada (M)

Department of Medical Neuroscience, and Brain Repair Centre, Faculty of Medicine, Dalhousie University. Life Science Research Institute, Halifax, Nova Scotia B3H-4R2, Canada.

James P Fawcett (JP)

Departments of Phamacology, Surgery, and Brain Repair Centre, Faculty of Medicine, Dalhousie University. Life Science Research Institute, Halifax, Nova Scotia B3H-4R2, Canada.

Angelo Iulianella (A)

Department of Medical Neuroscience, and Brain Repair Centre, Faculty of Medicine, Dalhousie University. Life Science Research Institute, Halifax, Nova Scotia B3H-4R2, Canada angelo.iulianella@dal.ca.

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