Role of Group 1 CD1-Restricted T Cells in Host Defense and Inflammatory Diseases.


Journal

Critical reviews in immunology
ISSN: 1040-8401
Titre abrégé: Crit Rev Immunol
Pays: United States
ID NLM: 8914819

Informations de publication

Date de publication:
2021
Historique:
entrez: 5 4 2022
pubmed: 1 1 2021
medline: 8 4 2022
Statut: ppublish

Résumé

Group 1 CD1-restricted T cells are members of the unconventional T cell family that recognize lipid antigens presented by CD1a, CD1b, and CD1c molecules. Although they developmentally mirror invariant natural killer T cells, they have diverse antigen specificity and functional capacity, with both anti-microbial and autoreactive targets. The role of group 1 CD1-restricted T cells has been best established in Mycobacterium tuberculosis (Mtb) infection in which a wide variety of lipid antigens have been identified and their ability to confer protection against Mtb infection in a CD1 transgenic mouse model has been shown. Group 1 CD1-restricted T cells have also been implicated in other infections, inflammatory conditions, and malignancies. In particular, autoreactive group 1 CD1-restricted T cells have been shown to play a role in several skin inflammatory conditions. The prevalence of group 1 CD1 autoreactive T cells in healthy individuals suggests the presence of regulatory mechanisms to suppress autoreactivity in homeostasis. The more recent use of group 1 CD1 tetramers and mouse models has allowed for better characterization of their phenotype, functional capacity, and underlying mechanisms of antigen-specific and autoreactive activation. These discoveries may pave the way for the development of novel vaccines and immunotherapies that target group 1 CD1-restricted T cells.

Identifiants

pubmed: 35381140
pii: 256bb987559bc247,291c234038b20587
doi: 10.1615/CritRevImmunol.2021040089
pmc: PMC10128144
mid: NIHMS1888845
doi:

Substances chimiques

Antigens, CD1 0
Lipids 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

1-21

Subventions

Organisme : NIGMS NIH HHS
ID : T32 GM008152
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI146072
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI057460
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI057460
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI145345
Pays : United States

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Auteurs

Eva Morgun (E)

Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.

Liang Cao (L)

Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.

Chyung-Ru Wang (CR)

Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.

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