Evidence for the major contribution of remodeling-based bone formation in sclerostin-deficient mice.
Antiresorptive agent
Bone formation
Bone modeling and remodeling
Bone resorption
Sclerostin
Journal
Bone
ISSN: 1873-2763
Titre abrégé: Bone
Pays: United States
ID NLM: 8504048
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
08
03
2022
revised:
28
03
2022
accepted:
29
03
2022
pubmed:
6
4
2022
medline:
25
5
2022
entrez:
5
4
2022
Statut:
ppublish
Résumé
Bone formation by osteoblasts is achieved through remodeling-based bone formation (RBBF) and modeling-based bone formation (MBBF). The former is when bone formation occurs after osteoclastic bone resorption to maintain bone mass and calcium homeostasis. The latter is when new bone matrices are added on the quiescent bone surfaces. Administration of anti-sclerostin neutralizing antibody promotes MBBF in ovariectomized rats and postmenopausal women. However, it remains to be elucidated which mode of bone formation mainly occurs in Sost-deficient mice under physiological conditions. Here, we show that two-thirds of bone formation involves RBBF in 12-week-old Sost-deficient mice (C57BL/6 background). Micro-computed tomography and histomorphometric analyses showed that the trabecular bone mass in Sost-KO mice was higher than that in Sost
Identifiants
pubmed: 35381389
pii: S8756-3282(22)00077-1
doi: 10.1016/j.bone.2022.116401
pii:
doi:
Substances chimiques
Adaptor Proteins, Signal Transducing
0
Glycoproteins
0
Intercellular Signaling Peptides and Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
116401Informations de copyright
Copyright © 2022. Published by Elsevier Inc.