Biosynthetic pathways of triterpenoids and strategies to improve their Biosynthetic Efficiency.
Biosynthetic pathways
Pentacyclic triterpenoids
Tetracyclic triterpenoids
Triterpenoids
Journal
Plant growth regulation
ISSN: 0167-6903
Titre abrégé: Plant Growth Regul
Pays: Netherlands
ID NLM: 9886958
Informations de publication
Date de publication:
2022
2022
Historique:
received:
13
01
2022
accepted:
18
03
2022
pubmed:
7
4
2022
medline:
7
4
2022
entrez:
6
4
2022
Statut:
ppublish
Résumé
"Triterpenoids" can be considered natural products derived from the cyclization of squalene, yielding 3-deoxytriterpenes (hydrocarbons) or 3-hydroxytriterpenes. Triterpenoids are metabolites of these two classes of triterpenes, produced by the functionalization of their carbon skeleton. They can be categorized into different groups based on their structural formula/design. Triterpenoids are an important group of compounds that are widely used in the fields of pharmacology, food, and industrial biotechnology. However, inadequate synthetic methods and insufficient knowledge of the biosynthesis of triterpenoids, such as their structure, enzymatic activity, and the methods used to produce pure and active triterpenoids, are key problems that limit the production of these active metabolites. Here, we summarize the derivatives, pharmaceutical properties, and biosynthetic pathways of triterpenoids and review the enzymes involved in their biosynthetic pathway. Furthermore, we concluded the screening methods, identified the genes involved in the pathways, and highlighted the appropriate strategies used to enhance their biosynthetic production to facilitate the commercial process of triterpenoids through the synthetic biology method.
Identifiants
pubmed: 35382096
doi: 10.1007/s10725-022-00818-9
pii: 818
pmc: PMC8969394
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
439-454Informations de copyright
© The Author(s), under exclusive licence to Springer Nature B.V. 2022.
Déclaration de conflit d'intérêts
Conflict of interestAll authors declare that there is no conflict of interest.
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