Genetic variants associated with longitudinal changes in brain structure across the lifespan.
Journal
Nature neuroscience
ISSN: 1546-1726
Titre abrégé: Nat Neurosci
Pays: United States
ID NLM: 9809671
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
received:
28
08
2020
accepted:
28
02
2022
pubmed:
7
4
2022
medline:
9
4
2022
entrez:
6
4
2022
Statut:
ppublish
Résumé
Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases. In this study, we identified common genetic variants that affect rates of brain growth or atrophy in what is, to our knowledge, the first genome-wide association meta-analysis of changes in brain morphology across the lifespan. Longitudinal magnetic resonance imaging data from 15,640 individuals were used to compute rates of change for 15 brain structures. The most robustly identified genes GPR139, DACH1 and APOE are associated with metabolic processes. We demonstrate global genetic overlap with depression, schizophrenia, cognitive functioning, insomnia, height, body mass index and smoking. Gene set findings implicate both early brain development and neurodegenerative processes in the rates of brain changes. Identifying variants involved in structural brain changes may help to determine biological pathways underlying optimal and dysfunctional brain development and aging.
Identifiants
pubmed: 35383335
doi: 10.1038/s41593-022-01042-4
pii: 10.1038/s41593-022-01042-4
pmc: PMC10040206
mid: NIHMS1784902
doi:
Banques de données
ClinicalTrials.gov
['NCT02534363', 'NCT02305832']
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
421-432Subventions
Organisme : NIA NIH HHS
ID : R01 AG058854
Pays : United States
Organisme : Medical Research Council
ID : MR/N027558/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R024065/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S020306/1
Pays : United Kingdom
Organisme : NIDA NIH HHS
ID : U01 DA041117
Pays : United States
Organisme : Medical Research Council
ID : MR/N000390/1
Pays : United Kingdom
Organisme : NIBIB NIH HHS
ID : P41 EB015922
Pays : United States
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : NIDA NIH HHS
ID : U24 DA041147
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA051039
Pays : United States
Organisme : Medical Research Council
ID : MR/S003444/1
Pays : United Kingdom
Organisme : NIDA NIH HHS
ID : U01 DA041120
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH120125
Pays : United States
Organisme : NIMH NIH HHS
ID : RC2 MH089995
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA051018
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG064955
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG068057
Pays : United States
Organisme : MRF
ID : MRF_MRF-058-0004-RG-DESRI
Pays : United Kingdom
Organisme : NIDA NIH HHS
ID : U01 DA041093
Pays : United States
Organisme : Medical Research Council
ID : MR/R00465X/1
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : U01 AG024904
Pays : United States
Organisme : Department of Health
Pays : United Kingdom
Organisme : NIDA NIH HHS
ID : U24 DA041123
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA051038
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG055367
Pays : United States
Organisme : Medical Research Council
ID : G1001245
Pays : United Kingdom
Organisme : NIDA NIH HHS
ID : U01 DA041134
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH116147
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH085772
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA041022
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH107327
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA041156
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA050987
Pays : United States
Organisme : NIBIB NIH HHS
ID : U54 EB020403
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH117601
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA051037
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA051016
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG054002
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA041025
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG060470
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA050989
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA041089
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA050988
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG058854
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA041106
Pays : United States
Organisme : NIMH NIH HHS
ID : K99 MH116115
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA041028
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA041048
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD074051
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA041148
Pays : United States
Organisme : Wellcome Trust
ID : 221890/Z/20/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M013111/1
Pays : United Kingdom
Organisme : Chief Scientist Office
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : R01 MH118349
Pays : United States
Organisme : MRF
ID : MRF_C0439
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0701120
Pays : United Kingdom
Organisme : MRF
ID : MRF_MRF-058-0009-RG-DESR-C0759
Pays : United Kingdom
Organisme : NIDA NIH HHS
ID : U01 DA041174
Pays : United States
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : R01 AG022381
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG050595
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG059874
Pays : United States
Investigateurs
Rüdiger Brühl
(R)
Dimitri Papadopoulos Orfanos
(D)
Tomáš Paus
(T)
Sabina Millenet
(S)
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature America, Inc.
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