Reliable Functionalization of 5,6-Fused Bicyclic N-Heterocycles Pyrazolopyrimidines and Imidazopyridazines via Zinc and Magnesium Organometallics.
DFT calculation
N-heterocycle
imidazopyridazines
magnesium
pyrazolopyrimidines
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765
Titre abrégé: Chemistry
Pays: Germany
ID NLM: 9513783
Informations de publication
Date de publication:
10 Jun 2022
10 Jun 2022
Historique:
received:
07
03
2022
pubmed:
7
4
2022
medline:
15
6
2022
entrez:
6
4
2022
Statut:
ppublish
Résumé
DFT-calculations allow prediction of the reactivity of uncommon N-heterocyclic scaffolds of pyrazolo[1,5-a]pyrimidines and imidazo[1,2-b]pyridazines and considerably facilitate their functionalization. The derivatization of these N-heterocycles was realized using Grignard reagents for nucleophilic additions to 5-chloropyrazolo[1,5-a]pyrimidines and TMP
Identifiants
pubmed: 35384103
doi: 10.1002/chem.202200733
pmc: PMC9321601
doi:
Substances chimiques
Indicators and Reagents
0
Pyrimidines
0
Magnesium
I38ZP9992A
Zinc
J41CSQ7QDS
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202200733Subventions
Organisme : Ludwig-Maximilians-Universität München
Organisme : Deutsche Forschungsgemeinschaft
Informations de copyright
© 2022 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.
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