Dynamic Changes in Breast Milk Microbiome in the Early Postpartum Period of Kenyan Women Living with HIV Are Influenced by Antibiotics but Not Antiretrovirals.
Anti-Bacterial Agents
/ therapeutic use
Anti-HIV Agents
/ therapeutic use
Anti-Retroviral Agents
/ therapeutic use
Female
Gastrointestinal Microbiome
HIV Infections
/ drug therapy
Humans
Infant
Infectious Disease Transmission, Vertical
/ prevention & control
Kenya
Milk, Human
Postpartum Period
Pregnancy
Pregnancy Complications, Infectious
/ drug therapy
Retrospective Studies
HIV
Kenya
antibiotics
breast milk microbiome
combination antiretroviral therapy
Journal
Microbiology spectrum
ISSN: 2165-0497
Titre abrégé: Microbiol Spectr
Pays: United States
ID NLM: 101634614
Informations de publication
Date de publication:
27 04 2022
27 04 2022
Historique:
pubmed:
7
4
2022
medline:
30
4
2022
entrez:
6
4
2022
Statut:
ppublish
Résumé
Shared bacteria between maternal breast milk and infant stool, infers that transfer of maternal breast milk microbiota through breastfeeding seeds the establishment of the infant gut microbiome. Whether combination antiretroviral therapy (cART) impacts the breast milk microbiota in women living with HIV is unknown. Since current standard of care for people living with HIV includes cART, it has been difficult to evaluate the impact of cART on the microbiome. Here, we performed a next-generation sequencing retrospective study from pre-ART era clinical trials in Nairobi, Kenya (between 2003-2006 before cART was standard of care) that tested the effects of ART regimens to prevent mother-to-child HIV transmission. Kenyan women living with HIV were randomized to receive either no ART during breastfeeding (
Identifiants
pubmed: 35384692
doi: 10.1128/spectrum.02080-21
pmc: PMC9045247
doi:
Substances chimiques
Anti-Bacterial Agents
0
Anti-HIV Agents
0
Anti-Retroviral Agents
0
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0208021Subventions
Organisme : NICHD NIH HHS
ID : R01 HD092311
Pays : United States
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