Revisiting Rustrela Virus: New Cases of Encephalitis and a Solution to the Capsid Enigma.

Eurasian otter South American coati capsid encephalitis intergenic region rubivirus rustrela virus sequencing yellow-necked field mouse

Journal

Microbiology spectrum
ISSN: 2165-0497
Titre abrégé: Microbiol Spectr
Pays: United States
ID NLM: 101634614

Informations de publication

Date de publication:
27 04 2022
Historique:
pubmed: 7 4 2022
medline: 30 4 2022
entrez: 6 4 2022
Statut: ppublish

Résumé

Rustrela virus (RusV; species Rubivirus strelense) is a recently discovered relative of rubella virus (RuV) that has been detected in cases of encephalitis in diverse mammals. Here, we diagnosed two additional cases of fatal RusV-associated meningoencephalitis in a South American coati (Nasua nasua) and a Eurasian or European otter (Lutra lutra) that were detected in a zoological garden with history of prior RusV infections. Both animals showed abnormal movement or unusual behavior and their brains tested positive for RusV using specific reverse transcription quantitative PCR (RT-qPCR) and RNA

Identifiants

pubmed: 35384712
doi: 10.1128/spectrum.00103-22
pmc: PMC9045237
doi:

Substances chimiques

Capsid Proteins 0
DNA, Intergenic 0
Nucleotides 0
RNA 63231-63-0

Types de publication

Case Reports Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0010322

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Auteurs

Florian Pfaff (F)

Institute of Diagnostic Virology, Friedrich-Loeffler-Institutgrid.417834.d, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany.

Angele Breithaupt (A)

Department of Experimental Animal Facilities and Biorisk Management, Friedrich-Loeffler-Institutgrid.417834.d, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany.

Dennis Rubbenstroth (D)

Institute of Diagnostic Virology, Friedrich-Loeffler-Institutgrid.417834.d, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany.

Sina Nippert (S)

Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institutgrid.417834.d, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany.

Christina Baumbach (C)

State Office for Agriculture, Food Safety and Fisheries, Rostock, Germany.

Sascha Gerst (S)

State Office for Agriculture, Food Safety and Fisheries, Rostock, Germany.

Christoph Langner (C)

Stralsund Zoological Garden, Stralsund, Germany.

Claudia Wylezich (C)

Institute of Diagnostic Virology, Friedrich-Loeffler-Institutgrid.417834.d, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany.

Arnt Ebinger (A)

Institute of Diagnostic Virology, Friedrich-Loeffler-Institutgrid.417834.d, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany.

Dirk Höper (D)

Institute of Diagnostic Virology, Friedrich-Loeffler-Institutgrid.417834.d, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany.

Rainer G Ulrich (RG)

Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institutgrid.417834.d, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany.

Martin Beer (M)

Institute of Diagnostic Virology, Friedrich-Loeffler-Institutgrid.417834.d, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany.

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Classifications MeSH