Grid-cell modules remain coordinated when neural activity is dissociated from external sensory cues.
entorhinal cortex
grid cells
neural circuits
neural coding
neural decoding
population coding
spatial coding
spatial memory
Journal
Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320
Informations de publication
Date de publication:
01 06 2022
01 06 2022
Historique:
received:
14
09
2021
revised:
25
01
2022
accepted:
09
03
2022
pubmed:
7
4
2022
medline:
7
6
2022
entrez:
6
4
2022
Statut:
ppublish
Résumé
The representation of an animal's position in the medial entorhinal cortex (MEC) is distributed across several modules of grid cells, each characterized by a distinct spatial scale. The population activity within each module is tightly coordinated and preserved across environments and behavioral states. Little is known, however, about the coordination of activity patterns across modules. We analyzed the joint activity patterns of hundreds of grid cells simultaneously recorded in animals that were foraging either in the light, when sensory cues could stabilize the representation, or in darkness, when such stabilization was disrupted. We found that the states of different modules are tightly coordinated, even in darkness, when the internal representation of position within the MEC deviates substantially from the true position of the animal. These findings suggest that internal brain mechanisms dynamically coordinate the representation of position in different modules, ensuring that they jointly encode a coherent and smooth trajectory.
Identifiants
pubmed: 35385698
pii: S0896-6273(22)00247-1
doi: 10.1016/j.neuron.2022.03.011
pmc: PMC9235855
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1843-1856.e6Informations de copyright
Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests E.I.M. is on the Advisory Board of Neuron. All other authors declare no competing interests.
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