A case of localized colorectal wild-type ATTR amyloidosis complicated by early stage colorectal cancer and a CMV-associated ulcer during the long-term follow-up.
ATTR amyloidosis
Early stage colorectal cancer
Endoscopic submucosal dissection (ESD)
Localized colorectal amyloidosis
Prognosis
Journal
Clinical journal of gastroenterology
ISSN: 1865-7265
Titre abrégé: Clin J Gastroenterol
Pays: Japan
ID NLM: 101477246
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
received:
05
02
2022
accepted:
18
03
2022
pubmed:
8
4
2022
medline:
7
6
2022
entrez:
7
4
2022
Statut:
ppublish
Résumé
Gastrointestinal involvement is a rare manifestation of systemic amyloidosis, and few reports have been published on localized amyloidosis of the colon. Only one case report has been published on the long-term prognosis of localized colorectal amyloidosis, and there are no previous reports on localized colorectal ATTR amyloidosis. Here, we report an 80-year-old male with localized colorectal wild-type ATTR amyloidosis who presented with edematous mucosa with vascular changes throughout the colon. He did not exhibit any symptoms or endoscopic exacerbation for 8 years after diagnosis. However, after 8 years, he developed early stage colorectal cancer and cytomegalovirus-associated ulcer. He was treated with endoscopic submucosal dissection, which was relatively challenging due to his hemorrhagic condition and poor elevation of the submucosa caused by amyloid deposits. Since the tumor was completely resected, he will undergo regular follow-up. Our review of 20 previous cases of localized colorectal amyloidosis revealed its clinical features and long-term prognosis. Specifically, ours is the second case of a diffuse pan-colon type of colorectal localized amyloidosis, which may lead to various complications, such as colorectal cancer, over a long period of time, and thus, regular follow-up is necessary.
Identifiants
pubmed: 35386058
doi: 10.1007/s12328-022-01628-2
pii: 10.1007/s12328-022-01628-2
doi:
Types de publication
Case Reports
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
603-610Informations de copyright
© 2022. Japanese Society of Gastroenterology.
Références
Talar-Wojnarowska R, Jamroziak K. Intestinal amyloidosis: clinical manifestations and diagnostic challenge. Adv Clin Exp Med. 2021;30:563–70.
doi: 10.17219/acem/133521
Alshehri SA, Hussein MRA. Primary localized amyloidosis of the intestine: a pathologist viewpoint. Gastroenterol Res. 2020;13:129–37.
doi: 10.14740/gr1303
Sze SF, Lam P, Lam YS, et al. Gastrointestinal: a rare cause of bloody diarrhea-gastrointestinal amyloidosis. J Gastroenterol Hepatol. 2016;31:1913.
doi: 10.1111/jgh.13440
Kyle RA, Gertz MA, Lacy MQ, et al. Localized AL amyloidosis of the colon: an unrecognized entity. Amyloid. 2003;10:36–41.
doi: 10.3109/13506120308995256
Nakazawa K, Saito Y, Yoshinaga S, et al. Endoscopic submucosal dissection for localized amyloidosis of the sigmoid colon. Endoscopy. 2022;54:E5-e6.
doi: 10.1055/a-1346-8645
Picardo S, Koro K, Seow CH. Localized gastrointestinal amyloidosis, manifesting as an isolated colonic ulcer, is a rare cause of hematochezia. Clin Gastroenterol Hepatol. 2020;18:A25.
doi: 10.1016/j.cgh.2019.01.035
Zhao J, Zhang X, Li S. Variable endoscopic appearance of localized colorectal amyloidosis. Clin Gastroenterol Hepatol. 2019;17:e131–2.
doi: 10.1016/j.cgh.2018.08.024
Kwon YH, Kim JY, Kim JH, et al. A case of primary colon amyloidosis presenting as hematochezia. Korean J Gastroenterol. 2012;59:44–7.
doi: 10.4166/kjg.2012.59.1.44
Antonini F, Goteri G, Macarri G. Bleeding localized amyloidosis of the colon. Dig Liver Dis. 2014;46:e13.
doi: 10.1016/j.dld.2014.04.003
Ogasawara N, Kitagawa W, Obayashi K, et al. Solitary amyloidosis of the sigmoid colon featuring submucosal tumor caused hematochezia. Intern Med. 2013;52:2523–7.
doi: 10.2169/internalmedicine.52.0944
Makazu M, Nakajima T. A case of localized AL amyloidosis of the sigmoid colon with lymphocytes exhibiting a premalignant status. Jpn J Clin Oncol. 2013;43:767.
doi: 10.1093/jjco/hyt089
Tsiouris A, Neale J, Stefanou A, et al. Primary amyloid of the colon mimicking ischemic colitis. Colorectal Dis. 2011;13:e12-13.
doi: 10.1111/j.1463-1318.2010.02456.x
Parks RW, O’Rourke D, Bharucha H, et al. Perforation of the sigmoid colon secondary to localised amyloidosis. Ulster Med J. 2002;71:144–6.
pubmed: 12513014
pmcid: 2475299
Chen JH, Lai SJ, Tsai PP, et al. Localized amyloidosis mimicking carcinoma of the colon. AJR Am J Roentgenol. 2002;179:536–7.
doi: 10.2214/ajr.179.2.1790536
Matsui H, Kato T, Inoue G, et al. Amyloidosis localized in the sigmoid colon. J Gastroenterol. 1996;31:607–11.
doi: 10.1007/BF02355067
Watanabe T, Kato K, Sugitani M, et al. A case of solitary amyloidosis localized within the transverse colon presenting as a submucosal tumor. Gastrointest Endosc. 1999;49:644–7.
doi: 10.1016/S0016-5107(99)70398-6
Deans GT, Hale RJ, McMahon RF, et al. Amyloid tumour of the colon. J Clin Pathol. 1995;48:592–3.
doi: 10.1136/jcp.48.6.592
Díaz Del Arco C, Fernández Aceñero MJ. Globular amyloidosis of the colon. Arab J Gastroenterol. 2018;19:96–9.
doi: 10.1016/j.ajg.2018.03.003
Tokoro C, Inamori M, Sekino Y, et al. Localized primary AL amyloidosis of the colon without other GI involvement. Gastrointest Endosc. 2011;74:925–6 (discussion 927).
doi: 10.1016/j.gie.2011.06.022
Hirata K, Sasaguri T, Kunoh M, et al. Solitary “amyloid ulcer” localized in the sigmoid colon without evidence of systemic amyloidosis. Am J Gastroenterol. 1997;92:356–7.
pubmed: 9040228
Martín-Arranz E, Pascual-Turrión JM, Martín-Arranz MD, et al. Focal globular amyloidosis of the colon. An exceptional diagnosis. Rev Esp Enferm Dig. 2010;102:555–6.
doi: 10.4321/S1130-01082010000900008
Threlkeld C, Nguyen TH. Isolated amyloidosis of the colon. J Am Osteopath Assoc. 1996;96:188–90.
pubmed: 8932596
Hokama A, Kishimoto K, Nakamoto M, et al. Endoscopic and histopathological features of gastrointestinal amyloidosis. World J Gastrointest Endosc. 2011;3:157–61.
doi: 10.4253/wjge.v3.i8.157
Sekijima Y. Transthyretin (ATTR) amyloidosis: clinical spectrum, molecular pathogenesis and disease-modifying treatments. J Neurol Neurosurg Psychiatry. 2015;86:1036–43.
doi: 10.1136/jnnp-2014-308724
Kandiel A, Lashner B. Cytomegalovirus colitis complicating inflammatory bowel disease. Am J Gastroenterol. 2006;101:2857–65.
doi: 10.1111/j.1572-0241.2006.00869.x
Cha JM, Lee JI, Choe JW, et al. Cytomegalovirus enteritis causing ileal perforation in an elderly immunocompetent individual. Yonsei Med J. 2010;51:279–83.
doi: 10.3349/ymj.2010.51.2.279