Dual-functional porous and cisplatin-loaded polymethylmethacrylate cement for reconstruction of load-bearing bone defect kills bone tumor cells.
Bone tumor treatment
Chemotherapeutic drug
Ex vivo biomechanical assessment
Local drug delivery
Porous polymethylmethacrylate cement
Journal
Bioactive materials
ISSN: 2452-199X
Titre abrégé: Bioact Mater
Pays: China
ID NLM: 101685294
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
received:
06
09
2021
revised:
14
12
2021
accepted:
18
12
2021
entrez:
7
4
2022
pubmed:
8
4
2022
medline:
8
4
2022
Statut:
epublish
Résumé
Malignant bone tumors are usually treated by resection of tumor tissue followed by filling of the bone defect with bone graft substitutes. Polymethylmethacrylate (PMMA) cement is the most commonly used bone substitute in clinical orthopedics in view of its reliability. However, the dense nature of PMMA renders this biomaterial unsuitable for local delivery of chemotherapeutic drugs to limit the recurrence of bone tumors. Here, we introduce porosity into PMMA cement by adding carboxymethylcellulose (CMC) to facilitate such local delivery of chemotherapeutic drugs, while retaining sufficient mechanical properties for bone reconstruction in load-bearing sites. Our results show that the mechanical strength of PMMA-based cements gradually decreases with increasing CMC content. Upon incorporation of ≥3% CMC, the PMMA-based cements released up to 18% of the loaded cisplatin, in contrast to cements containing lower amounts of CMC which only released less than 2% of the cisplatin over 28 days. This release of cisplatin efficiently killed osteosarcoma cells
Identifiants
pubmed: 35386344
doi: 10.1016/j.bioactmat.2021.12.023
pii: S2452-199X(21)00597-1
pmc: PMC8941180
doi:
Types de publication
Journal Article
Langues
eng
Pagination
120-130Informations de copyright
© 2022 The Authors.
Références
Semin Oncol. 2007 Jun;34(3):206-14
pubmed: 17560982
Br J Clin Pharmacol. 2019 Jun;85(6):1114-1124
pubmed: 30601585
Mater Sci Eng C Mater Biol Appl. 2016 Apr 1;61:190-8
pubmed: 26838840
Eur J Cancer. 2019 Mar;109:36-50
pubmed: 30685685
Biomaterials. 1983 Apr;4(2):128-30
pubmed: 6860754
Front Microbiol. 2019 Jul 25;10:1626
pubmed: 31402901
J Clin Oncol. 2015 Sep 20;33(27):3029-35
pubmed: 26304877
Acta Biomater. 2014 Oct;10(10):4058-70
pubmed: 24956564
Br J Cancer. 2005 Sep 19;93(6):678-87
pubmed: 16222314
Ann Oncol. 2018 Oct 1;29(Suppl 4):iv79-iv95
pubmed: 30285218
J Control Release. 2005 Feb 2;102(2):313-32
pubmed: 15653154
Ann Oncol. 2010 Oct;21 Suppl 7:vii320-5
pubmed: 20943636
Acta Orthop Traumatol Turc. 2013;47(3):184-92
pubmed: 23748618
Int J Cancer. 2012 Aug 15;131(4):E508-17
pubmed: 21913189
Oncol Rev. 2017 May 09;11(1):321
pubmed: 28584570
J Mater Chem B. 2014 Aug 14;2(30):4767-4788
pubmed: 32261769
Ann Oncol. 2009 May;20 Suppl 4:137-9
pubmed: 19454435
Clin Orthop Relat Res. 2003 Oct;(415 Suppl):S263-75
pubmed: 14600618
Cancer. 1995 Mar 1;75(5):1208-14
pubmed: 7850721
J Bone Joint Surg Br. 2003 Jul;85(5):712-6
pubmed: 12892195
Biomaterials. 2004 Apr;25(9):1697-714
pubmed: 14697871
Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6954-6963
pubmed: 30886100
Nat Rev Rheumatol. 2016 Nov;12(11):632-644
pubmed: 27652499
Radiother Oncol. 2018 Mar;126(3):547-557
pubmed: 29397209
Dalton Trans. 2018 May 15;47(19):6645-6653
pubmed: 29632935
Bone Res. 2021 Mar 16;9(1):18
pubmed: 33727543
J Bone Joint Surg Br. 2008 Jul;90(7):973-9
pubmed: 18591612
Oncol Lett. 2017 Aug;14(2):1648-1656
pubmed: 28789391
Clin Orthop Relat Res. 1994 Jul;(304):207-17
pubmed: 8020218
Nat Rev Cancer. 2013 Sep;13(9):611-23
pubmed: 23969692
Cancer Res. 2015 Jun 1;75(11):2151-8
pubmed: 25855383
J Biomech. 2009 May 29;42(8):1120-6
pubmed: 19344902
Nat Rev Drug Discov. 2011 Sep 16;10(10):767-77
pubmed: 21921921
J Bone Oncol. 2019 Jan 25;16:100220
pubmed: 31044134
Int Orthop. 2001;25(6):343-8
pubmed: 11820438
Br J Clin Pharmacol. 2019 Jun;85(6):1161-1168
pubmed: 30723928
Biomaterials. 1999 Oct;20(19):1783-90
pubmed: 10509188
Eur J Surg Oncol. 2008 Dec;34(12):1271-6
pubmed: 18191363
Eur Spine J. 2017 Dec;26(12):3216-3224
pubmed: 28168347
J Mater Sci Mater Med. 1997 Feb;8(2):75-83
pubmed: 15348774
Clin Orthop Relat Res. 1995 Mar;(312):173-86
pubmed: 7634601
Tissue Eng Part C Methods. 2010 Dec;16(6):1427-38
pubmed: 20524844
Int J Hyperthermia. 1997 May-Jun;13(3):287-306
pubmed: 9222812
J Biomater Appl. 2011 Feb;25(6):559-80
pubmed: 20089606
Semin Intervent Radiol. 2010 Jun;27(2):124-36
pubmed: 21629402
J Bone Joint Surg Br. 2011 Dec;93(12):1665-9
pubmed: 22161931
Front Cell Dev Biol. 2020 Jul 09;8:613
pubmed: 32754598
J Biomech. 1994 Sep;27(9):1127-36
pubmed: 7929462
Eur J Cancer. 2017 May;77:75-83
pubmed: 28365529
Clin Orthop Relat Res. 1991 Sep;(270):8-14
pubmed: 1884563
Arthroscopy. 2004 Jul;20(6):644-9
pubmed: 15241319
Jpn J Clin Oncol. 1992 Oct;22(5):347-53
pubmed: 1469796
J Biomech. 2003 Aug;36(8):1103-9
pubmed: 12831735
Biomaterials. 1990 Jul;11(5):299-304
pubmed: 2205300
J Prosthet Dent. 2003 Mar;89(3):261-7
pubmed: 12644801
Annu Rev Biomed Eng. 2018 Jun 4;20:119-143
pubmed: 29865872
Ann Transl Med. 2020 Sep;8(17):1081
pubmed: 33145300
Clin Nucl Med. 1993 Oct;18(10):821-8
pubmed: 7694820
World J Clin Cases. 2019 Nov 6;7(21):3632-3638
pubmed: 31750347
Sci Adv. 2019 Aug 02;5(8):eaax6946
pubmed: 31414050
J R Soc Interface. 2012 Dec 7;9(77):3503-13
pubmed: 22915633
Bull Hosp Jt Dis. 1993 Spring;53(1):68-74
pubmed: 8374496
Acta Biomater. 2010 Aug;6(8):3187-92
pubmed: 20197125
Nat Rev Clin Oncol. 2014 Jun;11(6):335-45
pubmed: 24821212
Theranostics. 2019 May 31;9(14):4192-4207
pubmed: 31281541
J Biomed Mater Res B Appl Biomater. 2013 Jul;101(5):813-25
pubmed: 23359449
Am J Vet Res. 2017 May;78(5):570-578
pubmed: 28441055
Int J Biol Sci. 2018 Jan 14;14(2):156-164
pubmed: 29483834
J Bone Joint Surg Br. 1989 Nov;71(5):804-11
pubmed: 2584251
Eur Spine J. 2003 Aug;12(4):421-6
pubmed: 12687437
Biomaterials. 2010 May;31(14):4146-56
pubmed: 20153893
J Bone Joint Surg Br. 1999 May;81(3):545-51
pubmed: 10872381
Med Phys. 1986 Mar-Apr;13(2):233-9
pubmed: 3702820