An overview of substrate stiffness guided cellular response and its applications in tissue regeneration.
Cell-matrix interaction
Cellular response
Mechanobiology
Substrate stiffness
Tissue engineering
Journal
Bioactive materials
ISSN: 2452-199X
Titre abrégé: Bioact Mater
Pays: China
ID NLM: 101685294
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
received:
22
10
2021
revised:
03
12
2021
accepted:
03
12
2021
entrez:
7
4
2022
pubmed:
8
4
2022
medline:
8
4
2022
Statut:
epublish
Résumé
Cell-matrix interactions play a critical role in tissue repair and regeneration. With gradual uncovering of substrate mechanical characteristics that can affect cell-matrix interactions, much progress has been made to unravel substrate stiffness-mediated cellular response as well as its underlying mechanisms. Yet, as a part of cell-matrix interaction biology, this field remains in its infancy, and the detailed molecular mechanisms are still elusive regarding scaffold-modulated tissue regeneration. This review provides an overview of recent progress in the area of the substrate stiffness-mediated cellular responses, including 1) the physical determination of substrate stiffness on cell fate and tissue development; 2) the current exploited approaches to manipulate the stiffness of scaffolds; 3) the progress of recent researches to reveal the role of substrate stiffness in cellular responses in some representative tissue-engineered regeneration varying from stiff tissue to soft tissue. This article aims to provide an up-to-date overview of cell mechanobiology research in substrate stiffness mediated cellular response and tissue regeneration with insightful information to facilitate interdisciplinary knowledge transfer and enable the establishment of prognostic markers for the design of suitable biomaterials.
Identifiants
pubmed: 35386347
doi: 10.1016/j.bioactmat.2021.12.005
pii: S2452-199X(21)00560-0
pmc: PMC8940767
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
82-102Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Références
Sci Rep. 2016 Sep 15;6:33462
pubmed: 27628933
Biomaterials. 2014 Feb;35(7):2207-17
pubmed: 24333028
Exp Cell Res. 2016 Apr 10;343(1):60-66
pubmed: 26524505
Acta Biomater. 2015 Apr;16:23-34
pubmed: 25617804
Biomaterials. 2003 Jun;24(13):2133-51
pubmed: 12699650
J Appl Physiol (1985). 1997 May;82(5):1626-36
pubmed: 9134913
Tissue Eng Part C Methods. 2019 Oct;25(10):593-608
pubmed: 31288616
Science. 2001 Nov 23;294(5547):1708-12
pubmed: 11721053
Biomacromolecules. 2013 Jun 10;14(6):2004-13
pubmed: 23639096
Mater Sci Eng C Mater Biol Appl. 2013 May 1;33(4):2376-85
pubmed: 23498272
Biofabrication. 2016 Jun 22;8(2):025020
pubmed: 27328736
Tissue Eng Part A. 2013 Jun;19(11-12):1275-84
pubmed: 23289622
Philos Trans R Soc Lond B Biol Sci. 2007 Aug 29;362(1484):1293-312
pubmed: 17588872
Cell Tissue Res. 2001 Sep;305(3):285-98
pubmed: 11572082
Biochim Biophys Acta. 2013 Jan;1828(1):147-56
pubmed: 22245380
Acta Biomater. 2016 Dec;46:68-78
pubmed: 27693666
Acta Biomater. 2015 Apr;17:16-25
pubmed: 25644451
J Biol Eng. 2016 Nov 21;10:16
pubmed: 27895704
Acta Biomater. 2015 Jul;20:1-9
pubmed: 25871537
Sci Adv. 2021 May 26;7(22):
pubmed: 34039601
Acta Biomater. 2016 Sep 15;42:247-257
pubmed: 27370906
Sci Adv. 2017 May 31;3(5):e1602883
pubmed: 28580421
Acta Biomater. 2013 Feb;9(2):5170-80
pubmed: 23079022
J Shoulder Elbow Surg. 2012 Aug;21(8):1064-71
pubmed: 21885301
Nat Rev Mol Cell Biol. 2006 Apr;7(4):265-75
pubmed: 16607289
Ann Biomed Eng. 2008 Sep;36(9):1565-79
pubmed: 18618260
Biomater Sci. 2020 May 21;8(10):2714-2733
pubmed: 32307482
Adv Drug Deliv Rev. 2002 Jan 17;54(1):13-36
pubmed: 11755704
J Mech Behav Biomed Mater. 2012 Dec;16:66-72
pubmed: 23149099
Stem Cell Res Ther. 2013 Jan 31;4(1):10
pubmed: 23369796
ACS Appl Mater Interfaces. 2018 Aug 22;10(33):27669-27680
pubmed: 30063134
Acta Biomater. 2017 Aug;58:244-253
pubmed: 28602855
Biophys J. 2004 Nov;87(5):3050-65
pubmed: 15339798
Curr Opin Biotechnol. 2013 Oct;24(5):834-40
pubmed: 23916867
Cell Biol Int. 2013 Jun;37(6):608-16
pubmed: 23447501
Biomaterials. 2012 Oct;33(28):6672-81
pubmed: 22738780
Adv Healthc Mater. 2013 Jun;2(6):895-907
pubmed: 23281344
Mater Sci Eng C Mater Biol Appl. 2021 Feb;119:111613
pubmed: 33321656
Acta Biomater. 2016 Mar 01;32:210-222
pubmed: 26790775
Polymers (Basel). 2020 Dec 16;12(12):
pubmed: 33339216
Nanotechnology. 2013 Jan 18;24(2):025701
pubmed: 23238052
Exerc Sport Sci Rev. 2000 Jul;28(3):99-107
pubmed: 10916700
Tissue Eng Part B Rev. 2016 Jun;22(3):173-82
pubmed: 26669274
Sci Rep. 2014 Apr 16;4:4706
pubmed: 24736500
Biomaterials. 2010 Mar;31(7):1626-35
pubmed: 19962188
Biofabrication. 2018 Mar 28;10(3):035004
pubmed: 29595143
ACS Appl Mater Interfaces. 2015 Apr 22;7(15):8302-12
pubmed: 25815434
Tissue Eng Part A. 2008 Sep;14(9):1459-60
pubmed: 18774909
Biofabrication. 2014 Sep;6(3):035008
pubmed: 24867684
Acta Biomater. 2020 May;108:237-249
pubmed: 32205213
Eur J Cell Biol. 2006 Apr;85(3-4):165-73
pubmed: 16360240
Acta Biomater. 2013 Mar;9(3):5698-707
pubmed: 23131385
Biomater Sci. 2014 May 1;2(5):703-709
pubmed: 24778793
Acta Biomater. 2018 Apr 15;71:132-147
pubmed: 29462712
J Biomech. 2019 Dec 3;97:109367
pubmed: 31607375
Acta Biomater. 2012 Feb;8(2):519-30
pubmed: 21989230
Adv Drug Deliv Rev. 2015 Apr;84:1-29
pubmed: 25236302
J Biomech. 2009 Sep 18;42(13):2143-50
pubmed: 19640539
Biomater Sci. 2015 Feb;3(2):352-60
pubmed: 26218126
Biomed Microdevices. 2005 Dec;7(4):281-93
pubmed: 16404506
Biofabrication. 2017 May 11;9(2):025015
pubmed: 28349900
J Appl Physiol (1985). 2005 Apr;98(4):1547-53
pubmed: 15772065
Biomaterials. 2001 May;22(10):1077-84
pubmed: 11352088
Nat Commun. 2015 Apr 28;6:6933
pubmed: 25917746
Nat Commun. 2012 Apr 24;3:792
pubmed: 22531177
Acta Biomater. 2008 Jul;4(4):1005-15
pubmed: 18359672
Biomaterials. 2009 May;30(14):2724-34
pubmed: 19201462
J Clin Invest. 2018 Jan 2;128(1):157-174
pubmed: 29202470
Bioact Mater. 2021 Jun 16;8:494-504
pubmed: 34541415
Acta Biomater. 2012 Dec;8(12):4268-77
pubmed: 22890285
J Biomed Mater Res A. 2016 Apr;104(4):833-41
pubmed: 26650620
Tissue Eng. 2007 Oct;13(10):2525-38
pubmed: 17822359
Biomed Mater. 2018 Feb 02;13(2):024102
pubmed: 29133625
Cancer Lett. 2022 Jan 1;524:245-258
pubmed: 34715250
Am J Physiol Heart Circ Physiol. 2010 Jan;298(1):H221-8
pubmed: 19897714
J Orthop Res. 2013 Sep;31(9):1360-5
pubmed: 23606500
Colloids Surf B Biointerfaces. 2021 Mar;199:111503
pubmed: 33338883
Life Sci. 2017 Jun 1;178:42-48
pubmed: 28433510
Acta Biomater. 2014 Jun;10(6):2718-26
pubmed: 24434536
Biomater Sci. 2020 Dec 15;8(24):7033-7081
pubmed: 33150878
Regen Ther. 2021 May 28;18:102-111
pubmed: 34141834
Biomaterials. 2012 Feb;33(5):1281-90
pubmed: 22118821
Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9660-5
pubmed: 15210979
PLoS One. 2015 Aug 11;10(8):e0135519
pubmed: 26262877
J Biomater Sci Polym Ed. 2006;17(9):969-84
pubmed: 17094636
Ann Biomed Eng. 2020 Mar;48(3):1071-1089
pubmed: 31485876
J Biomech. 2004 Aug;37(8):1263-9
pubmed: 15212932
Adv Mater. 2017 May;29(19):
pubmed: 28295624
Sci Rep. 2014 Aug 28;4:6215
pubmed: 25163607
J Biomed Mater Res A. 2010 Sep 15;94(4):1162-71
pubmed: 20694983
Biophys J. 2017 Aug 8;113(3):645-655
pubmed: 28793219
Tissue Eng Part A. 2011 Dec;17(23-24):2931-42
pubmed: 21882895
Biomaterials. 2005 Dec;26(34):6836-45
pubmed: 15972236
ACS Appl Mater Interfaces. 2014 Mar 26;6(6):4089-101
pubmed: 24588215
Acta Biomater. 2015 Jul;20:22-31
pubmed: 25858557
Tissue Eng Part A. 2014 Aug;20(15-16):2115-26
pubmed: 24694244
J Mech Behav Biomed Mater. 2008 Oct;1(4):326-35
pubmed: 19627797
Biomaterials. 2012 May;33(15):3835-45
pubmed: 22369963
Biomech Model Mechanobiol. 2008 Aug;7(4):309-21
pubmed: 17713801
ACS Appl Mater Interfaces. 2016 Sep 21;8(37):24962-73
pubmed: 27580039
Macromol Biosci. 2013 May;13(5):551-61
pubmed: 23420700
Int J Biol Macromol. 2020 Apr 15;149:707-716
pubmed: 32014477
ACS Appl Mater Interfaces. 2015 Jul 29;7(29):15790-802
pubmed: 26151287
Adv Healthc Mater. 2016 Sep;5(17):2237-47
pubmed: 27377355
Curr Biol. 2010 Aug 10;20(15):R649-54
pubmed: 20692617
Acta Biomater. 2011 Mar;7(3):1133-9
pubmed: 20977951
Acta Biomater. 2011 Jan;7(1):406-16
pubmed: 20807594
Biomaterials. 2018 Sep;178:281-292
pubmed: 29945065
Cell Prolif. 2018 Oct;51(5):e12478
pubmed: 30039894
Biomaterials. 2010 Feb;31(6):1148-57
pubmed: 19892395
Trends Biotechnol. 1990 Mar;8(3):71-8
pubmed: 1366500
Cancer Cell. 2016 Jun 13;29(6):783-803
pubmed: 27300434
Acta Biomater. 2017 Mar 1;50:41-55
pubmed: 28011142
Colloids Surf B Biointerfaces. 2017 Jan 1;149:379-387
pubmed: 27855357
Polymers (Basel). 2016 Jul 26;8(8):
pubmed: 30974547
Annu Rev Biomed Eng. 2018 Jun 4;20:49-72
pubmed: 29328778
Comput Biol Med. 2017 Oct 1;89:337-354
pubmed: 28858648
Acta Biomater. 2017 Apr 15;53:572-584
pubmed: 28213101
Biomaterials. 2004 Aug;25(19):4749-57
pubmed: 15120521
Acta Biomater. 2013 Mar;9(3):5475-83
pubmed: 23153761
J Mech Behav Biomed Mater. 2021 Jun;118:104439
pubmed: 33691231
Acta Biomater. 2014 Oct;10(10):4367-76
pubmed: 24954911
Biomaterials. 2013 Sep;34(27):6355-66
pubmed: 23747008
Exp Mol Med. 2019 May 9;51(5):1-8
pubmed: 31073120
Adv Healthc Mater. 2017 Apr;6(7):
pubmed: 28135049
J Biomech. 1999 Apr;32(4):437-41
pubmed: 10213035
Cell Motil Cytoskeleton. 2005 Jan;60(1):24-34
pubmed: 15573414
Biomaterials. 2015 Dec;73:296-307
pubmed: 26431909
Acta Biomater. 2012 May;8(5):1813-25
pubmed: 22326787
Acta Biomater. 2016 Feb;31:156-166
pubmed: 26621695
ACS Appl Mater Interfaces. 2016 Feb 10;8(5):3079-91
pubmed: 26765285
J Cell Mol Med. 2007 Mar-Apr;11(2):176-205
pubmed: 17488472
Artif Organs. 2013 Feb;37(2):166-74
pubmed: 23067437
J Biomed Mater Res A. 2015 Sep;103(9):2909-18
pubmed: 25690698
Acta Biomater. 2019 Apr 15;89:84-94
pubmed: 30878448
Annu Rev Biomed Eng. 2013;15:227-51
pubmed: 23642242
Biochem Biophys Res Commun. 2018 May 15;499(3):642-647
pubmed: 29601813
Tissue Eng Part A. 2018 Jan;24(1-2):1-10
pubmed: 28385124
ACS Appl Mater Interfaces. 2019 Feb 20;11(7):6867-6880
pubmed: 30676736
Biomacromolecules. 2012 Mar 12;13(3):826-32
pubmed: 22320432
J Mater Chem B. 2014 Jan 21;2(3):305-313
pubmed: 32261509
J Tissue Eng Regen Med. 2018 Apr;12(4):1012-1019
pubmed: 29024545
Biomaterials. 2013 Jul;34(20):4749-57
pubmed: 23562052
Polymers (Basel). 2021 May 26;13(11):
pubmed: 34073335
Adv Healthc Mater. 2018 Jun;7(12):e1701277
pubmed: 29603679
Matrix Biol. 2003 Mar;22(1):73-80
pubmed: 12714044
Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13661-5
pubmed: 9391082
Biomaterials. 2011 Dec;32(34):8915-26
pubmed: 21889796
Materials (Basel). 2017 Jan 10;10(1):
pubmed: 28772411
Bioact Mater. 2020 Oct 06;6(3):890-904
pubmed: 33073063
Adv Mater. 2011 May 3;23(17):1971-5
pubmed: 21523834
Langmuir. 2004 Dec 21;20(26):11684-91
pubmed: 15595798
Acta Biomater. 2008 Sep;4(5):1161-71
pubmed: 18515199
Lancet. 2011 Apr 9;377(9773):1276-87
pubmed: 21450337
Biomaterials. 2014 Jan;35(4):1176-84
pubmed: 24211076
Tissue Eng Part A. 2014 Apr;20(7-8):1145-55
pubmed: 24329135
Mater Sci Eng C Mater Biol Appl. 2017 Jun 1;75:1281-1288
pubmed: 28415417
Biomaterials. 2009 Dec;30(36):6867-78
pubmed: 19775749
Biofabrication. 2021 Jul 27;13(4):
pubmed: 34186522
Nat Mater. 2017 Dec;16(12):1243-1251
pubmed: 28967913
Biomaterials. 2007 Jan;28(2):134-46
pubmed: 17011028
Crit Rev Biomed Eng. 2003;31(4):255-331
pubmed: 15095950
Acta Biomater. 2010 Nov;6(11):4305-13
pubmed: 20570642
J Anat. 2015 Dec;227(6):717-31
pubmed: 25382217
Cells Tissues Organs. 2014;200(1):6-12
pubmed: 25765065
ACS Appl Mater Interfaces. 2016 Sep 7;8(35):22884-91
pubmed: 27534990
Biomaterials. 2021 Aug;275:120969
pubmed: 34157563
Carbohydr Polym. 2018 Apr 15;186:290-298
pubmed: 29455990
Biomaterials. 2009 Nov;30(33):6530-40
pubmed: 19732950
J Biomed Mater Res A. 2011 Oct;99(1):16-28
pubmed: 21793193
J Mater Chem B. 2019 Mar 14;7(10):1726-1733
pubmed: 32254914
Int J Med Robot. 2005 Sep;1(3):87-95
pubmed: 17518395
Acta Biomater. 2013 Dec;9(12):9508-21
pubmed: 23928332
Front Bioeng Biotechnol. 2020 Dec 14;8:597661
pubmed: 33381498
Biomacromolecules. 2013 Jul 8;14(7):2179-88
pubmed: 23745709
Adv Healthc Mater. 2017 Jun;6(11):
pubmed: 28337850
Adv Healthc Mater. 2021 Feb;10(3):e2001244
pubmed: 33274860
Acta Biomater. 2018 Mar 15;69:83-94
pubmed: 29378326
Biomed Mater. 2021 Feb 17;16(2):022004
pubmed: 33594992