Subcutaneous calcinosis: Is it different between systemic sclerosis and dermatomyositis?
Calcinosis
dermatomyositis
dystrophic calcifications
juvenile dermatomyositis
scleroderma
Journal
Journal of scleroderma and related disorders
ISSN: 2397-1991
Titre abrégé: J Scleroderma Relat Disord
Pays: England
ID NLM: 101685427
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
received:
07
06
2021
accepted:
27
09
2021
entrez:
7
4
2022
pubmed:
8
4
2022
medline:
8
4
2022
Statut:
ppublish
Résumé
Calcinosis cutis is the deposition of insoluble calcium in the skin and subcutaneous tissues. It is a manifestation of several autoimmune connective tissue diseases, most frequently with systemic sclerosis and juvenile dermatomyositis, followed by adult dermatomyositis. Autoimmune connective tissue disease-associated calcinosis is of the dystrophic subtype, which occurs at sites of damaged tissue in the setting of normal serum calcium and phosphate levels. In juvenile dermatomyositis, calcinosis is considered a marker of ongoing disease activity and possibly inadequate treatment, while in adult dermatomyositis, it is a hallmark of skin damage due to chronic rather than active disease. Calcinosis is associated with long disease duration in systemic sclerosis and dermatomyositis, anti-polymyositis/sclerosis autoantibodies in systemic sclerosis and NXP-2 and melanoma differentiation-associated gene 5 in dermatomyositis. Calcinosis in systemic sclerosis occurs most frequently in the hands, particularly the fingers, whereas in dermatomyositis, it affects mainly the trunk and extremities. The primary mineral component of calcinosis is hydroxyapatite in systemic sclerosis and carbonate apatite in dermatomyositis. Calcinosis in dermatomyositis and systemic sclerosis share some pathogenic mechanisms, but vascular hypoxia seems to play a more important role in systemic sclerosis, whereas the release of calcium from mitochondria in muscle cells damaged by myopathy may be a primary mechanism contributing to dermatomyositis-related calcinosis. Multiple treatment strategies for dermatomyositis and systemic sclerosis-related calcinosis have been used with variable results. Early aggressive treatment of underlying myositis in patients with dermatomyositis may improve long-term outcomes of calcinosis. A better understanding of the pathogenesis of calcinosis is needed to improve treatment options.
Identifiants
pubmed: 35386947
doi: 10.1177/23971983211053245
pii: 10.1177_23971983211053245
pmc: PMC8922676
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
7-23Informations de copyright
© The Author(s) 2021.
Déclaration de conflit d'intérêts
Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Références
Semin Arthritis Rheum. 2020 Feb;50(1):E4-E5
pubmed: 31353058
Semin Arthritis Rheum. 2014 Oct;44(2):e5-6
pubmed: 24842570
J Rheumatol. 2008 Nov;35(11):2201-5
pubmed: 18843781
Curr Rheumatol Rep. 2014 Dec;16(12):467
pubmed: 25366934
Medicine (Baltimore). 2017 Dec;96(51):e8980
pubmed: 29390428
Curr Rheumatol Rep. 2020 Aug 27;22(10):73
pubmed: 32856128
Rheumatol Int. 2018 Oct;38(10):1901-1910
pubmed: 30132216
Arthritis Rheum. 1990 Aug;33(8):1287-93
pubmed: 2390132
Neurology. 2018 Jun 5;90(23):e2068-e2076
pubmed: 29728522
Autoimmunity. 2015;48(8):542-51
pubmed: 26334795
Arthritis Care Res (Hoboken). 2015 Mar;67(3):425-30
pubmed: 25155948
Pediatr Clin North Am. 2018 Aug;65(4):739-756
pubmed: 30031496
Semin Arthritis Rheum. 2016 Oct;46(2):200-208
pubmed: 27312381
Autoimmun Rev. 2020 Jun;19(6):102533
pubmed: 32234404
Acta Derm Venereol. 2016 Feb;96(2):257-8
pubmed: 26258586
J Am Acad Dermatol. 2012 Mar;66(3):424-9
pubmed: 21745699
J Rheumatol. 2010 Dec;37(12):2638-9
pubmed: 21123340
Brain. 2019 Nov 1;142(11):e59
pubmed: 31603187
BMJ Case Rep. 2012 Aug 18;2012:
pubmed: 22907859
J Am Acad Dermatol. 1995 Nov;33(5 Pt 1):693-706; quiz 707-10
pubmed: 7593766
J Am Acad Dermatol. 2020 Nov;83(5):1518-1520
pubmed: 32622148
Autoimmun Rev. 2019 Mar;18(3):262-269
pubmed: 30639647
J Rheumatol. 2012 Oct;39(10):2043-4
pubmed: 23028028
Int J Clin Pract. 1998 Nov-Dec;52(8):593-4
pubmed: 10622063
Semin Arthritis Rheum. 2012 Jun;41(6):822-9
pubmed: 22221908
Pediatr Rheumatol Online J. 2014 Jan 07;12:2
pubmed: 24397895
Arch Dermatol. 2008 May;144(5):585-7
pubmed: 18490584
Semin Arthritis Rheum. 2017 Dec;47(3):451-455
pubmed: 28779847
Am J Med. 1987 Jul;83(1):72-6
pubmed: 3605184
J Am Acad Dermatol. 2015 Jul;73(1):174-6
pubmed: 26089058
Clin Rheumatol. 2017 Jan;36(1):111-117
pubmed: 27718018
Arthritis Res Ther. 2009;11(5):R159
pubmed: 19857267
J Pediatr. 2001 May;138(5):763-6
pubmed: 11343059
Rheumatology (Oxford). 2001 Apr;40(4):410-3
pubmed: 11312379
J Rheumatol. 2008 Nov;35(11):2206-13
pubmed: 18843778
J Am Acad Dermatol. 2011 Jul;65(1):1-12; quiz 13-4
pubmed: 21679810
Rheumatology (Oxford). 2016 Dec;55(12):2148-2155
pubmed: 27593964
Rheumatol Int. 2016 Jul;36(7):961-5
pubmed: 27007612
Arthritis Rheum. 1995 Nov;38(11):1646-54
pubmed: 7488286
Curr Rheumatol Rep. 2021 Feb 8;23(2):13
pubmed: 33555459
Clin Rheumatol. 1986 Dec;5(4):527-30
pubmed: 3816102
Clin Rheumatol. 2009 Jun;28 Suppl 1:S57-63
pubmed: 19360363
Hum Pathol. 2006 Feb;37(2):190-7
pubmed: 16426919
Clin Rheumatol. 2020 Jan;39(1):113-118
pubmed: 31214867
J Hand Surg Am. 1977 Jul;2(4):318-24
pubmed: 556475
Rheumatology (Oxford). 2006 Nov;45(11):1349-55
pubmed: 17050587
Scand J Rheumatol. 2016;45(2):114-7
pubmed: 26448593
J Am Acad Dermatol. 2009 Jun;60(6):1076-7
pubmed: 19467386
Rheumatology (Oxford). 2021 Nov 3;60(11):5028-5041
pubmed: 33580257
N Engl J Med. 2015 Jul 9;373(2):173
pubmed: 26154790
Rheumatology (Oxford). 2021 Jun 18;60(6):2958-2962
pubmed: 33249499
J Autoimmun. 2019 Jun;100:131-136
pubmed: 30862449
Curr Opin Rheumatol. 2020 Nov;32(6):472-478
pubmed: 32890031
Rheumatology (Oxford). 2009 Aug;48(8):876-82
pubmed: 19542215
J Am Acad Dermatol. 2015 Mar;72(3):449-55
pubmed: 25595720
Ann Rheum Dis. 2004 Oct;63(10):1341-3
pubmed: 15361398
J Clin Endocrinol Metab. 1997 Nov;82(11):3536-42
pubmed: 9360503
Case Rep Rheumatol. 2020 May 28;2020:4073879
pubmed: 32550037
Clin Rheumatol. 2013 Feb;32(2):281-3
pubmed: 23179007
Rheumatology (Oxford). 2016 Sep;55(9):1610-4
pubmed: 27241706
Clin Exp Dermatol. 2015 Mar;40(2):211-2
pubmed: 25250643
Scand J Rheumatol. 2017 Mar;46(2):118-121
pubmed: 27682520
J Am Acad Dermatol. 2002 Oct;47(4):505-11
pubmed: 12271292
Rom J Intern Med. 2014 Apr-Jun;52(2):55-67
pubmed: 25338341
Aesthetic Plast Surg. 2013 Dec;37(6):1214-9
pubmed: 24142114
Arch Dermatol. 2012 Apr;148(4):455-62
pubmed: 22184719
Arthritis Care Res (Hoboken). 2021 Sep;73(9):1332-1337
pubmed: 32475057
Mod Rheumatol. 2018 May;28(3):518-522
pubmed: 28722530
Semin Arthritis Rheum. 2011 Apr;40(5):455-60
pubmed: 20864145
Clin Exp Rheumatol. 2010 Jan-Feb;28(1):135-40
pubmed: 20346254
Clin Rheumatol. 2005 Apr;24(2):172-3
pubmed: 15565396
Springerplus. 2015 Apr 30;4:201
pubmed: 25977892
Rheumatology (Oxford). 2014 Dec;53(12):2204-8
pubmed: 24987158
J Am Acad Dermatol. 2002 May;46(5 Suppl):S148-50
pubmed: 12004297
J Rheumatol. 2011 Jul;38(7):1436-40
pubmed: 21677003
Rheumatology (Oxford). 2008 Jul;47(7):1031-7
pubmed: 18448482
Arthritis Res Ther. 2019 Jan 24;21(1):35
pubmed: 30678703
Arthritis Rheumatol. 2014 Jun;66(6):1608-15
pubmed: 24577935
J Dermatol. 2016 Jul;43(7):729-57
pubmed: 26972733
Rheumatology (Oxford). 2000 Mar;39(3):333-4
pubmed: 10788545
Br J Rheumatol. 1995 Jun;34(6):576-8
pubmed: 7633802
Arthritis Rheum. 2000 Aug;43(8):1866-73
pubmed: 10943878
Arthritis Rheum. 2009 Apr 15;61(4):501-8
pubmed: 19333978
Arthritis Rheum. 1998 Feb;41(2):373
pubmed: 9485097
Rheumatology (Oxford). 2012 Dec;51(12):2234-8
pubmed: 22923763
Mod Rheumatol. 2015 Jul;25(4):615-20
pubmed: 25800510
Int J Rheum Dis. 2015 May;18(4):459-65
pubmed: 24618222
Ann Rheum Dis. 2011 Apr;70(4):630-3
pubmed: 21131648
Rheumatology (Oxford). 2005 Jun;44(6):824-6
pubmed: 15769789
Pediatr Dermatol. 2019 Jul;36(4):e102-e103
pubmed: 31134636
Ann Rheum Dis. 1998 Apr;57(4):252-4
pubmed: 9709184
J Am Acad Dermatol. 2005 Nov;53(5 Suppl 1):S263-5
pubmed: 16227105
Proc R Soc Med. 1974 Nov;67(11):1166-8
pubmed: 4438303
Arthritis Care Res (Hoboken). 2018 Jun;70(6):938-943
pubmed: 28898558
J Am Acad Dermatol. 2020 Feb;82(2):317-325
pubmed: 31302187
Br J Dermatol. 2014 May;170(5):1073-9
pubmed: 24329416
J Clin Neuromuscul Dis. 2001 Jun;2(4):191-3
pubmed: 19078635
Ann Rheum Dis. 2003 Mar;62(3):267-9
pubmed: 12594118
Rheumatology (Oxford). 2014 May;53(5):960-1
pubmed: 24255162
J Clin Pharm Ther. 2016 Feb;41(1):94-6
pubmed: 26667314
Pediatr Rheumatol Online J. 2017 Sep 21;15(1):71
pubmed: 28934971
Medicine (Baltimore). 2013 Jul;92(4):223-243
pubmed: 23877355
Presse Med. 2009 Feb;38(2):291-302
pubmed: 19062246
Clin Exp Rheumatol. 2014 May-Jun;32(3):408-9
pubmed: 24238152
Nat Commun. 2019 Mar 13;10(1):1203
pubmed: 30867423
J Rheumatol. 2015 Feb;42(2):345-6
pubmed: 25641967
JAMA Dermatol. 2014 Jul;150(7):724-9
pubmed: 24869801
J Eur Acad Dermatol Venereol. 2018 Aug;32(8):1352-1359
pubmed: 29524269
BMJ Case Rep. 2016 May 31;2016:
pubmed: 27247203
J Dtsch Dermatol Ges. 2020 Oct;18(10):1181-1183
pubmed: 32743917
Br J Dermatol. 2001 Apr;144(4):894-7
pubmed: 11298557
Semin Arthritis Rheum. 2020 Oct;50(5):891-896
pubmed: 32898758
J Rheumatol. 2013 Nov;40(11):1881-90
pubmed: 24037552
Clin Exp Rheumatol. 2017 Mar-Apr;35(2):303-308
pubmed: 27908312
J Rheumatol. 1996 Dec;23(12):2152-5
pubmed: 8970055
Clin Exp Rheumatol. 2016 Sep-Oct;34 Suppl 100(5):177-180
pubmed: 27494629
Joint Bone Spine. 2017 May;84(3):341-344
pubmed: 27955821
Am J Med. 1988 Apr;84(4):795-6
pubmed: 3400673
Clin Calcium. 2005 Sep;15 Suppl 1:75-8; discussion 78-9
pubmed: 16272635
Br J Dermatol. 2016 Sep;175(3):608-11
pubmed: 26799451
Semin Arthritis Rheum. 2005 Jun;34(6):805-12
pubmed: 15942915
Rheumatology (Oxford). 2021 Nov 3;60(11):e387-e388
pubmed: 33961025
Ann Intern Med. 1978 Nov;89(5 Pt 1):648-9
pubmed: 717938
Clin Exp Dermatol. 2019 Jul;44(5):e189-e192
pubmed: 30251264
Rheumatology (Oxford). 2017 Feb;56(2):247-254
pubmed: 27837048
Rheumatology (Oxford). 2008 Jun;47(6):877-80
pubmed: 18403404
Semin Arthritis Rheum. 2019 Oct;49(2):279-282
pubmed: 30981516
Semin Arthritis Rheum. 2016 Dec;46(3):344-349
pubmed: 27371996
Br J Dermatol. 2018 Jun;178(6):1412-1415
pubmed: 28667747
Scand J Rheumatol. 2016 Jul;45(4):317-20
pubmed: 26812367