Antigen Uptake After Intradermal Microinjection Depends on Antigen Nature and Formulation, but Not on Injection Depth.

Bet v 1 allergen specific immunotherapy antigen uptake injection depth intradermal injection liposomes ovalbumin

Journal

Frontiers in allergy
ISSN: 2673-6101
Titre abrégé: Front Allergy
Pays: Switzerland
ID NLM: 9918227355906676

Informations de publication

Date de publication:
2021
Historique:
received: 16 12 2020
accepted: 01 03 2021
entrez: 7 4 2022
pubmed: 8 4 2022
medline: 8 4 2022
Statut: epublish

Résumé

The skin is an attractive alternative administration route for allergy vaccination, as the skin is rich in dendritic cells (DCs) and is easily accessible. In the skin multiple subsets of DCs with distinct roles reside at different depths. In this study antigen (=allergen for allergy) formulations were injected in

Identifiants

pubmed: 35386985
doi: 10.3389/falgy.2021.642788
pmc: PMC8974696
doi:

Types de publication

Journal Article

Langues

eng

Pagination

642788

Informations de copyright

Copyright © 2021 Leboux, Schipper, van Capel, Kong, van der Maaden, Kros, Jiskoot, de Jong and Bouwstra.

Déclaration de conflit d'intérêts

KvdM was employed by the company uPRAX. WJ is a scientific advisor at Coriolis Pharma, Martinsried, Germany. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Romain J T Leboux (RJT)

Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, Netherlands.

Pim Schipper (P)

Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, Netherlands.

Toni M M van Capel (TMM)

Department of Experimental Immunology, Academic Medical Center, Amsterdam, Netherlands.

Lily Kong (L)

Division of Supramolecular Chemistry, Leiden Institute of Chemistry, Leiden University, Leiden, Netherlands.
Tongji School of Pharmacy, HuaZhong University of Science and Technology, Wuhan, China.

Koen van der Maaden (K)

Tumor Immunology Group, Department of Immunology, Leiden University Medical Center, Leiden, Netherlands.
TECO Development GmbH, Rheinbach, Germany.

Alexander Kros (A)

Division of Supramolecular Chemistry, Leiden Institute of Chemistry, Leiden University, Leiden, Netherlands.

Wim Jiskoot (W)

Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, Netherlands.

Esther C de Jong (EC)

Department of Experimental Immunology, Academic Medical Center, Amsterdam, Netherlands.

Joke A Bouwstra (JA)

Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, Netherlands.

Classifications MeSH