TLR Signals in Epithelial Cells in the Nasal Cavity and Paranasal Sinuses.
NFκB
Poly(I:C)
allergic rhinitis
chronic rhinosinusitis
intracellular zinc
nasal epithelial cells
nasal polyps
Journal
Frontiers in allergy
ISSN: 2673-6101
Titre abrégé: Front Allergy
Pays: Switzerland
ID NLM: 9918227355906676
Informations de publication
Date de publication:
2021
2021
Historique:
received:
21
09
2021
accepted:
01
11
2021
entrez:
7
4
2022
pubmed:
8
4
2022
medline:
8
4
2022
Statut:
epublish
Résumé
The respiratory tract is constantly at risk of invasion by microorganisms such as bacteria, viruses, and fungi. In particular, the mucosal epithelium of the nasal cavity and paranasal sinuses is at the very forefront of the battles between the host and the invading pathogens. Recent studies have revealed that the epithelium not only constitutes a physical barrier but also takes an essential role in the activation of the immune system. One of the mechanisms equipped in the epithelium to fight against microorganisms is the Toll-like receptor (TLR) response. TLRs recognize common structural components of microorganisms and activate the innate immune system, resulting in the production of a plethora of cytokines and chemokines in the response against microbes. As the epithelia-derived cytokines are deeply involved in the pathogenesis of inflammatory conditions in the nasal cavity and paranasal sinuses, such as chronic rhinosinusitis (CRS) and allergic rhinitis (AR), the molecules involved in the TLR response may be utilized as therapeutic targets for these diseases. There are several differences in the TLR response between nasal and bronchial epithelial cells, and knowledge of the TLR signals in the upper airway is sparse compared to that in the lower airway. In this review, we provide recent evidence on TLR signaling in the upper airway, focusing on the expression, regulation, and responsiveness of TLRs in human nasal epithelial cells (HNECs). We also discuss how TLRs in the epithelium are involved in the pathogenesis of, and possible therapeutic targeting, for CRS and AR.
Identifiants
pubmed: 35387020
doi: 10.3389/falgy.2021.780425
pmc: PMC8974762
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
780425Informations de copyright
Copyright © 2021 Suzuki, Cooksley, Suzuki, Ramezanpour, Nakazono, Nakamaru, Homma and Vreugde.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Interferon Cytokine Res. 2016 Mar;36(3):169-79
pubmed: 26540312
J Steroid Biochem Mol Biol. 2017 Jul;171:201-208
pubmed: 28377308
J Immunol Res. 2016;2016:2643297
pubmed: 28127565
Front Immunol. 2018 Mar 16;9:516
pubmed: 29616030
Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):3919-24
pubmed: 10760263
PLoS One. 2014 Jun 02;9(6):e98239
pubmed: 24886842
Ann Allergy Asthma Immunol. 2015 Apr;114(4):289-98
pubmed: 25704964
Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11786-91
pubmed: 25074919
Front Immunol. 2020 Nov 12;11:599083
pubmed: 33281825
Steroids. 2010 Jan;75(1):1-12
pubmed: 19818358
J Am Chem Soc. 2018 Mar 28;140(12):4446-4454
pubmed: 29512390
Am J Respir Crit Care Med. 2014 Sep 15;190(6):628-38
pubmed: 25117756
Trends Mol Med. 2007 Nov;13(11):460-9
pubmed: 18029230
Allergol Int. 2019 Oct;68(4):403-412
pubmed: 31402319
Clin Microbiol Rev. 2008 Jan;21(1):13-25
pubmed: 18202435
Nat Immunol. 2011 Jan;12(1):21-7
pubmed: 21113163
Am J Respir Crit Care Med. 2013 Aug 15;188(4):432-9
pubmed: 23805875
Pharmacol Res. 2020 Feb;152:104619
pubmed: 31887355
Sci Rep. 2018 Jul 27;8(1):11325
pubmed: 30054566
Rhinol Suppl. 2012 Mar;23:3 p preceding table of contents, 1-298
pubmed: 22764607
Am J Respir Crit Care Med. 2015 Sep 15;192(6):682-94
pubmed: 26067893
Cell Mol Immunol. 2019 Mar;16(3):225-235
pubmed: 30792500
Clin Exp Allergy. 2012 Feb;42(2):218-28
pubmed: 22233535
EMBO J. 2004 Jun 16;23(12):2369-80
pubmed: 15152190
Rhinology. 2020 Feb 20;58(Suppl S29):1-464
pubmed: 32077450
Rhinology. 2009 Dec;47(4):413-8
pubmed: 19936369
Allergy. 2015 Aug;70(8):995-1003
pubmed: 25945591
Respir Med. 2014 Dec;108(12):1816-9
pubmed: 25456711
Virology. 1996 May 15;219(2):339-49
pubmed: 8638399
J Exp Med. 2008 Jul 7;205(7):1601-10
pubmed: 18591409
Immunobiology. 2015 Apr;220(4):445-51
pubmed: 25532794
Structure. 2011 Apr 13;19(4):447-59
pubmed: 21481769
Pathogens. 2021 Jul 05;10(7):
pubmed: 34357998
Clin Transl Allergy. 2015 Dec 14;5:42
pubmed: 26668716
FASEB J. 2009 Sep;23(9):2810-9
pubmed: 19376817
Respir Res. 2005 Sep 07;6:100
pubmed: 16146574
Am J Rhinol. 2007 Jan-Feb;21(1):110-6
pubmed: 17283572
Eur Arch Otorhinolaryngol. 2017 Jan;274(1):283-288
pubmed: 27522661
Am J Respir Cell Mol Biol. 2011 Aug;45(2):189-201
pubmed: 21330463
PLoS One. 2016 Apr 06;11(4):e0152808
pubmed: 27050744
Life Sci. 2019 Sep 15;233:116671
pubmed: 31336122
Front Immunol. 2014 Aug 12;5:386
pubmed: 25161655
J Allergy Clin Immunol. 2017 Oct;140(4):950-958
pubmed: 28602936
Front Cell Infect Microbiol. 2021 Apr 26;11:655666
pubmed: 33981629
Immunol Lett. 2017 Sep;189:55-63
pubmed: 28392198
Rhinology. 2020 Oct 1;58(5):451-459
pubmed: 32542237
Am J Rhinol. 2006 Mar-Apr;20(2):138-44
pubmed: 16686375
Int Arch Allergy Immunol. 2011;156(3):297-304
pubmed: 21720175
Allergol Int. 2021 Apr;70(2):190-200
pubmed: 33127267
Toxicol Appl Pharmacol. 2011 Jan 1;250(1):29-38
pubmed: 20932985
Cell Commun Signal. 2021 Jan 25;19(1):10
pubmed: 33494775
J Immunol. 2013 Aug 15;191(4):1808-17
pubmed: 23863901
Cell Tissue Res. 2009 Nov;338(2):283-93
pubmed: 19763625
Am J Rhinol Allergy. 2014 Sep-Oct;28(5):374-7
pubmed: 25198021
Mol Cell Biol. 2000 Sep;20(18):6891-903
pubmed: 10958685
Allergy. 2018 Feb;73(2):459-469
pubmed: 28771767
Trends Biochem Sci. 2017 Apr;42(4):297-311
pubmed: 28118948
J Allergy Clin Immunol. 2015 Jun;135(6):1476-85.e7
pubmed: 25725991
Mol Cell Biol. 2010 Oct;30(19):4564-74
pubmed: 20679482
Infect Immun. 2004 Dec;72(12):7275-81
pubmed: 15557653
Allergy. 2014 Sep;69(9):1154-61
pubmed: 24924975
Immune Netw. 2020 Apr 23;20(3):e21
pubmed: 32655969
J Biochem. 2017 Feb 1;161(2):135-144
pubmed: 28069866
J Allergy Clin Immunol. 2014 Jan;133(1):121-9.e1-2
pubmed: 23870670
Biochem J. 2003 Jul 1;373(Pt 1):211-20
pubmed: 12672265
Allergy. 2015 Sep;70(9):1169-80
pubmed: 26095319
Invest Ophthalmol Vis Sci. 2014 Jun 03;55(9):5653-60
pubmed: 24894401
Diabetes. 2011 Dec;60(12):3235-45
pubmed: 22110092
J Allergy Clin Immunol. 2013 Sep;132(3):593-600.e12
pubmed: 23688414
Am J Respir Cell Mol Biol. 2013 Nov;49(5):741-50
pubmed: 23590308
World Allergy Organ J. 2020 Mar 09;13(3):100109
pubmed: 32180893
Clin Exp Allergy. 2020 Apr;50(4):471-478
pubmed: 31943442
Cancer Res. 2000 Jul 1;60(13):3477-83
pubmed: 10910059
Allergy Asthma Proc. 2011 May-Jun;32(3):239-47
pubmed: 21535913
J Mol Endocrinol. 2002 Apr;28(2):69-78
pubmed: 11932204
PLoS One. 2012;7(3):e32924
pubmed: 22412951
Nutrients. 2017 Nov 25;9(12):
pubmed: 29186856
Ann Allergy Asthma Immunol. 2017 Oct;119(4):310-316.e2
pubmed: 28870448
Eur Respir J. 2005 Mar;25(3):552-63
pubmed: 15738302
Am J Rhinol Allergy. 2015 May-Jun;29(3):175-81
pubmed: 25975248
Allergy. 2020 Feb;75(2):446-449
pubmed: 31318982
Science. 2008 Apr 18;320(5874):379-81
pubmed: 18420935
Int J Mol Sci. 2017 Oct 24;18(10):
pubmed: 29064429
APMIS. 2015 Aug;123(8):716-25
pubmed: 26061394
Mol Immunol. 2015 Dec;68(2 Pt B):476-83
pubmed: 26463158
Otolaryngol Head Neck Surg. 2020 Dec;163(6):1097-1108
pubmed: 32539494
Mol Cell Biochem. 2016 Dec;423(1-2):197-206
pubmed: 27704463
Clin Immunol. 2007 Sep;124(3):345-52
pubmed: 17602875
Cytokine. 2015 Aug;74(2):171-4
pubmed: 25819430
Clin Exp Immunol. 2017 Jan;187(1):100-112
pubmed: 27667736
J Exp Med. 2019 Feb 4;216(2):384-406
pubmed: 30674564
Allergy. 2018 Oct;73(10):2095-2097
pubmed: 29935023
J Allergy Clin Immunol. 2013 Feb;131(2):549-61
pubmed: 23036747
Nature. 2006 May 4;441(7089):101-5
pubmed: 16625202
Biochim Biophys Acta. 2010 Aug;1804(8):1604-16
pubmed: 19766737
Front Immunol. 2019 Mar 04;10:364
pubmed: 30886621
Thorax. 2017 Jul;72(7):635-645
pubmed: 27885166
Eur Arch Otorhinolaryngol. 2016 Jul;273(7):1779-88
pubmed: 26518209
Am J Respir Cell Mol Biol. 2018 Oct;59(4):500-510
pubmed: 29767533
J Immunol. 2000 Jun 15;164(12):6509-19
pubmed: 10843709
J Steroid Biochem Mol Biol. 2010 May 31;120(2-3):69-75
pubmed: 20346397
J Med Chem. 2018 Dec 13;61(23):10922-10928
pubmed: 30395713
Am J Respir Cell Mol Biol. 2004 Sep;31(3):358-64
pubmed: 15191912
Allergol Int. 2020 Jul;69(3):331-345
pubmed: 32473790
Allergy. 2001 Jun;56(6):498-505
pubmed: 11421893
Allergy. 2018 Nov;73(11):2251-2254
pubmed: 29987901
Laryngoscope. 2014 Apr;124(4):E115-22
pubmed: 24122812
Am J Rhinol Allergy. 2012 Mar-Apr;26(2):104-9
pubmed: 22182736
Science. 1995 Oct 13;270(5234):286-90
pubmed: 7569976
Microbiol Spectr. 2016 Dec;4(6):
pubmed: 28084212
Clin Exp Immunol. 2010 Jun;160(3):403-10
pubmed: 20345983
Allergy Asthma Immunol Res. 2011 Jul;3(3):186-93
pubmed: 21738884
J Allergy Clin Immunol. 2015 Dec;136(6):1442-1453
pubmed: 26654193
Infect Immun. 2005 Nov;73(11):7151-60
pubmed: 16239509