The Nose as a Route for Therapy: Part 1. Pharmacotherapy.
allergic rhinitis
chronic rhinosinusitis
drug delivery
intranasal route
lysine aspirin
mucociliary clearance
nasal epithelium
saline douche
Journal
Frontiers in allergy
ISSN: 2673-6101
Titre abrégé: Front Allergy
Pays: Switzerland
ID NLM: 9918227355906676
Informations de publication
Date de publication:
2021
2021
Historique:
received:
05
12
2020
accepted:
08
01
2021
entrez:
7
4
2022
pubmed:
22
2
2021
medline:
22
2
2021
Statut:
epublish
Résumé
This article reviews nasal structure and function in the light of intranasal pharmacotherapy. The nose provides an accessible, fast route for local treatment of nose and sinus diseases, with lower doses than are necessary systemically and few adverse effects. It can also be used for other medications as it has sufficient surface area protected from local damage by mucociliary clearance, absence of digestive enzymes, responsive blood flow, and provides a rapid route to the central nervous system.
Identifiants
pubmed: 35387039
doi: 10.3389/falgy.2021.638136
pmc: PMC8974766
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
638136Informations de copyright
Copyright © 2021 Cingi, Bayar Muluk, Mitsias, Papadopoulos, Klimek, Laulajainen-Hongisto, Hytönen, Toppila-Salmi and Scadding.
Déclaration de conflit d'intérêts
AL-H reports receiving funding from Orion Research Foundation, outside of this submitted work. GS reports fees and consultancies from ALK, Mylan, Bayer, GSK outside the submitted work. ST-S reports a grant of GSK and consultancies for ERT, Novartis, Sanofi Pharma and Roche outside the submitted work. LK reports grants and personal fees from Allergopharma, grants and personal fees from MEDA/Mylan, personal fees from HAL Allergie, grants from ALK Abelló, grants and personal fees from LETI Pharma, grants from Stallergenes, grants from Quintiles, grants and personal fees from Sanofi, grants from ASIT biotech, grants from Lofarma, personal fees from Allergy Therapeut., grants from AstraZeneca, grants from GSK, grants from Inmunotk, personal fees from Cassella med, outside the submitted work; and Membership of AeDA, DGHNO, Deutsche Akademie für Allergologie und klinische Immunologie, HNO-BV, GPA, EAACI. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Ann Allergy. 1991 Dec;67(6):588-92
pubmed: 1750721
Int Arch Allergy Immunol. 2010;151(2):137-41
pubmed: 19752567
Jpn J Pharmacol. 1997 Feb;73(2):145-53
pubmed: 9074948
Allergy. 2011 Sep;66(9):1216-23
pubmed: 21605125
Eur Respir J. 2003 Feb;21(2):308-12
pubmed: 12608446
Clin Exp Allergy. 2017 Jul;47(7):856-889
pubmed: 30239057
Otolaryngol Head Neck Surg. 2007 Dec;137(6):918-24
pubmed: 18036421
Laryngoscope Investig Otolaryngol. 2016 Jul 05;1(4):96-105
pubmed: 28894807
Clin Transl Allergy. 2020 Jan 3;10:1
pubmed: 31908763
In Vivo. 1998 Sep-Oct;12(5):481-4
pubmed: 9827354
J Am Osteopath Assoc. 1999 Jul;99(7 Suppl):S7-12
pubmed: 10478514
J Allergy Clin Immunol. 1999 Sep;104(3 Pt 1):623-9
pubmed: 10482838
Clin Immunol. 2015 Oct;160(2):349-57
pubmed: 26083948
J Allergy Clin Immunol. 2014 Oct;134(4):883-90
pubmed: 24767875
Otolaryngol Head Neck Surg. 2007 Nov;137(5):815-21
pubmed: 17967652
J Ocul Pharmacol Ther. 1996 Winter;12(4):401-7
pubmed: 8951676
J Laryngol Otol. 2018 Aug;132(8):673-679
pubmed: 30070184
Curr Med Res Opin. 2006 Jan;22(1):151-7
pubmed: 16393441
Curr Med Res Opin. 2007 Oct;23(10):2441-52
pubmed: 17723160
Immunol Allergy Clin North Am. 2011 Aug;31(3):601-17
pubmed: 21737044
Clin Otolaryngol Allied Sci. 1979 Dec;4(6):407-11
pubmed: 160846
Int Arch Allergy Immunol. 2008;147(4):323-30
pubmed: 18622139
J Immunol. 1997 Sep 15;159(6):2932-40
pubmed: 9300717
Clin Exp Allergy. 1998 Oct;28(10):1228-36
pubmed: 9824389
N Engl J Med. 2018 Sep 13;379(11):1060-1070
pubmed: 30207919
Rhinology. 2020 Jun 1;58(3):213-217
pubmed: 32415826
Rhinology. 2020 Feb 20;58(Suppl S29):1-464
pubmed: 32077450
Laryngoscope. 2005 Aug;115(8):1385-90
pubmed: 16094110
Laryngoscope. 1997 Jan;107(1):62-6
pubmed: 9001267
Int Arch Allergy Appl Immunol. 1989;90(1):67-70
pubmed: 2478485
Laryngoscope. 2017 Mar;127(3):550-555
pubmed: 27859303
Allergy Asthma Proc. 2007 Sep-Oct;28(5):592-9
pubmed: 18034980
J Allergy Clin Immunol. 1998 May;101(5):581-6
pubmed: 9600492
Sci Rep. 2018 Nov 12;8(1):16710
pubmed: 30420763
Clin Exp Allergy. 2002 Apr;32(4):489-98
pubmed: 11972592
Rhinology. 2020 Apr 1;58(2):82-111
pubmed: 32226949
Laryngoscope. 1997 Apr;107(4):500-3
pubmed: 9111380
Expert Rev Respir Med. 2019 Jan;13(1):53-62
pubmed: 30518277
Clin Otolaryngol Allied Sci. 2000 Dec;25(6):558-60
pubmed: 11122299
J Allergy Clin Immunol. 2005 Feb;115(2):316-22
pubmed: 15696087
J Allergy Clin Immunol Pract. 2016 Jul-Aug;4(4):565-72
pubmed: 27393770
Proc Am Thorac Soc. 2011 Mar;8(1):31-9
pubmed: 21364219
Int J Immunopathol Pharmacol. 2018 Jan-Dec;32:2058738418802676
pubmed: 30350744
Arch Otolaryngol Head Neck Surg. 2008 Jan;134(1):67-74
pubmed: 18209140
J Allergy Clin Immunol Pract. 2020 Nov - Dec;8(10):3565-3574
pubmed: 32693216
J Am Osteopath Assoc. 2004 May;104(5 Suppl 5):S7-15
pubmed: 15176523
Allergy. 2000 Feb;55(2):116-34
pubmed: 10726726
Clin Exp Immunol. 2009 Nov;158(2):164-73
pubmed: 19737138
Clin Rev Allergy Immunol. 2013 Aug;45(1):75-86
pubmed: 23184151
Allergy. 2008 Apr;63 Suppl 86:8-160
pubmed: 18331513
Immunol Allergy Clin North Am. 2013 May;33(2):211-22
pubmed: 23639709
Curr Opin Otolaryngol Head Neck Surg. 2017 Feb;25(1):30-34
pubmed: 27849653
Clin Exp Allergy. 2013 Aug;43(8):874-80
pubmed: 23889241
J Allergy Clin Immunol. 2013 Aug;132(2):336-41
pubmed: 23806634
Thorax. 2000 Oct;55 Suppl 2:S75-8
pubmed: 10992567
Respir Med. 1995 Sep;89 Suppl A:3-18
pubmed: 7569173
Expert Opin Pharmacother. 2014 Jan;15(1):73-83
pubmed: 24219793
Cochrane Database Syst Rev. 2016 Apr 26;4:CD011995
pubmed: 27115216
Am J Rhinol Allergy. 2018 Jul;32(4):269-279
pubmed: 29774747
J Laryngol Otol. 2007 Dec;121(12):1156-60
pubmed: 17697437
Int Arch Allergy Immunol. 2005 Aug;137(4):310-4
pubmed: 15970639
Int Arch Allergy Immunol. 2014;163(3):225-33
pubmed: 24603043
Clin Exp Allergy. 1995 May;25(5):391-4
pubmed: 7553240
J Allergy. 1969 Sep;44(3):129-45
pubmed: 5258820
J Laryngol Otol. 1967 Sep;81(9):953-86
pubmed: 6050985
Thorax. 1988 Oct;43(10):756-61
pubmed: 2462755
J Neurosci. 2010 Apr 7;30(14):4999-5007
pubmed: 20371820
Laryngoscope. 2002 May;112(5):858-64
pubmed: 12150618
Int Forum Allergy Rhinol. 2018 Jan;8(1):49-53
pubmed: 29105347
N Engl J Med. 2002 Nov 7;347(19):1493-9
pubmed: 12421891
Cell Tissue Res. 2007 Nov;330(2):257-69
pubmed: 17768643
Curr Med Res Opin. 2009 Aug;25(8):2021-41
pubmed: 19569975
Expert Opin Drug Metab Toxicol. 2009 Jan;5(1):91-102
pubmed: 19220164
J Allergy Clin Immunol. 2007 Jan;119(1):157-64
pubmed: 17208597
Allergy. 2008 Sep;63(9):1228-34
pubmed: 18699939
Allergy. 2007 Oct;62(10):1111-8
pubmed: 17521312
Respir Med. 2020 May;166:105947
pubmed: 32250875
Br Med J. 1972 Mar 4;1(5800):585-90
pubmed: 4335298
Am J Respir Crit Care Med. 2000 Jun;161(6):2051-7
pubmed: 10852787
Am J Respir Crit Care Med. 2007 Oct 1;176(7):659-66
pubmed: 17615387
Iran J Pharm Res. 2017 Fall;16(4):1639-1647
pubmed: 29552073
HNO. 2000 Jul;48(7):544-55
pubmed: 10955235
Arch Fam Med. 1998 Jan-Feb;7(1):39-43
pubmed: 9443697
Acta Otolaryngol. 2004 Nov;124(9):1059-62
pubmed: 15513550
Ann Allergy Asthma Immunol. 2002 Nov;89(5):474-8
pubmed: 12452205
Expert Opin Pharmacother. 2016;17(5):657-69
pubmed: 26800187
BMJ. 1998 Dec 12;317(7173):1624-9
pubmed: 9848901
J Fam Pract. 2002 Dec;51(12):1049-55
pubmed: 12540331
J Allergy Clin Immunol. 2000 Jul;106(1 Pt 1):5-16
pubmed: 10887299
Clin Otolaryngol Allied Sci. 1995 Dec;20(6):561-3
pubmed: 8665721
J Allergy Clin Immunol. 2015 Mar;135(3):676-81.e1
pubmed: 25282015
J Allergy Clin Immunol. 1996 Oct;98(4):751-8
pubmed: 8876550
Am J Rhinol. 2007 Jul-Aug;21(4):499-503
pubmed: 17882923
Am J Rhinol Allergy. 2016 Nov 1;30(6):391-396
pubmed: 28124648
J Allergy Clin Immunol. 1998 May;101(5):602-5
pubmed: 9600495
Int Arch Allergy Immunol. 2001 Jun;125(2):164-75
pubmed: 11435734
Respirology. 2013 May;18(4):711-7
pubmed: 23441755
Eur Respir J. 2014 Feb;43(2):343-73
pubmed: 24337046
Br J Pharmacol. 2006 Jun;148(3):245-54
pubmed: 16604091
Eur J Pharmacol. 1994 Feb 15;266(3):219-27
pubmed: 8174605
Laryngoscope. 2003 Feb;113(2):284-9
pubmed: 12567083
J Control Release. 2000 May 3;66(1):73-9
pubmed: 10708880
Mol Cell Endocrinol. 2011 Mar 15;335(1):2-13
pubmed: 20398732
J Allergy Clin Immunol Pract. 2017 Jul - Aug;5(4):1061-1070.e3
pubmed: 28286156
Allergy Asthma Immunol Res. 2011 Jan;3(1):3-10
pubmed: 21217919
J Clin Med. 2019 Sep 02;8(9):
pubmed: 31480806
J Allergy Clin Immunol. 2001 Nov;108(5 Suppl):S147-334
pubmed: 11707753
Clin Exp Allergy. 1997 Apr;27(4):438-44
pubmed: 9146938
J Allergy Clin Immunol. 2006 May;117(5):1054-62
pubmed: 16675332
Rhinology. 2018 Jun 1;56(2):111-117
pubmed: 29476191
Ann Allergy. 1991 Mar;66(3):237-44
pubmed: 1672493
Prim Care. 2016 Sep;43(3):519-26
pubmed: 27545740
Cochrane Database Syst Rev. 2018 Jun 22;6:CD012597
pubmed: 29932206
J Biol Chem. 1999 Oct 15;274(42):29994-30000
pubmed: 10514483
Rhinology. 2011 Aug;49(3):272-280
pubmed: 21858255
J Allergy Clin Immunol. 2005 Nov;116(5):970-5
pubmed: 16275362
J Allergy Clin Immunol. 2014 May;133(5):1332-9, 1339.e1-3
pubmed: 24139494
Am J Rhinol Allergy. 2012 Sep-Oct;26(5):e119-25
pubmed: 23168142
Eur J Pharm Biopharm. 2004 Jul;58(1):131-5
pubmed: 15207546
Clin Otolaryngol. 2013 Aug;38(4):297-305
pubmed: 23714166
Drug Discov Today. 2002 Sep 15;7(18):967-75
pubmed: 12546871
J Allergy Clin Immunol. 2015 Feb;135(2):299-310; quiz 311
pubmed: 25662302
Clin Transl Allergy. 2020 Mar 13;10:9
pubmed: 32190296
Allergy. 2019 Jan;74(1):28-39
pubmed: 30216468
Clin Exp Allergy. 2002 Jun;32(6):906-13
pubmed: 12047438
World Allergy Organ J. 2014 Jul 29;7(1):18
pubmed: 25097720
Eur Respir J. 2003 Feb;21(2):313-6
pubmed: 12608447
Ther Clin Risk Manag. 2008 Oct;4(5):1009-22
pubmed: 19209282
J Immunol. 1996 Jun 1;156(11):4422-8
pubmed: 8666816
J Allergy Clin Immunol. 2001 Mar;107(3):469-76
pubmed: 11240947
Allergy. 2015 Jul;70(7):828-35
pubmed: 25855099
Ann Allergy Asthma Immunol. 1996 May;76(5):469-75
pubmed: 8630722
Allergy Asthma Proc. 1998 Jan-Feb;19(1):23-9
pubmed: 9532321
J Vet Med Sci. 2018 Mar 2;80(2):323-332
pubmed: 29225322
Ann Allergy Asthma Immunol. 2002 Nov;89(5):479-84
pubmed: 12452206
Int J Immunopathol Pharmacol. 2012 Jul-Sep;25(3):721-30
pubmed: 23058022
Arerugi. 1994 Mar;43(3):441-7
pubmed: 8198453
J Allergy Clin Immunol. 2018 Jan;141(1):250-256
pubmed: 28550988
Braz J Otorhinolaryngol. 2019 Nov - Dec;85(6):716-723
pubmed: 30057254
Gynecol Endocrinol. 1996 Jun;10(3):165-70
pubmed: 8862491
Eur Arch Otorhinolaryngol. 2009 May;266(5):685-9
pubmed: 18802718
Allergy. 2013;68(5):659-65
pubmed: 23464577
J Allergy Clin Immunol. 1992 Aug;90(2):242-9
pubmed: 1386857
Curr Opin Allergy Clin Immunol. 2017 Aug;17(4):247-254
pubmed: 28590311
Expert Rev Clin Immunol. 2014 May;10(5):657-65
pubmed: 24684687
Eur Arch Otorhinolaryngol. 2000 Dec;257(10):537-41
pubmed: 11195032
Int J Endocrinol. 2012;2012:561018
pubmed: 23213332
Ann Pharmacother. 2005 Dec;39(12):1984-9
pubmed: 16278257
Am J Otolaryngol. 2011 May-Jun;32(3):235-9
pubmed: 20537762
Allergy Asthma Proc. 2003 Sep-Oct;24(5):331-7
pubmed: 14619333
Vascul Pharmacol. 2019 Feb;113:1-8
pubmed: 30391545
Proc Am Thorac Soc. 2011 Mar;8(1):121-31
pubmed: 21364230
Clin Ther. 2005 May;27(5):543-53
pubmed: 15978303
Curr Allergy Asthma Rep. 2020 Jun 3;20(7):28
pubmed: 32495003
Otolaryngol Head Neck Surg. 2004 Nov;131(5):679-82
pubmed: 15523448
Helv Paediatr Acta. 1984 Oct;39(4):341-5
pubmed: 6543846
Eur J Pharm Biopharm. 2008 Nov;70(3):735-40
pubmed: 18684400
Eur Respir J. 2015 Sep;46(3):622-39
pubmed: 26206872
Allergy Asthma Proc. 2010 Mar-Apr;31(2):112-9
pubmed: 20406593
Mol Pharmacol. 2002 Feb;61(2):391-9
pubmed: 11809864
J Allergy Clin Immunol. 1997 Oct;100(4):511-9
pubmed: 9338546
Cochrane Database Syst Rev. 2015 Apr 20;(4):CD006821
pubmed: 25892369
J Allergy Clin Immunol Pract. 2019 Jan;7(1):165-174.e4
pubmed: 29894793
Allergy. 2008 Oct;63(10):1292-300
pubmed: 18782107
Allergy Asthma Immunol Res. 2011 Jul;3(3):148-56
pubmed: 21738880
J Allergy Clin Immunol. 2011 Dec;128(6):1139-1150.e4
pubmed: 22035879
J Clin Med. 2019 Jan 09;8(1):
pubmed: 30634447
Cochrane Database Syst Rev. 2015 Jul 14;(7):CD010591
pubmed: 26171907