Transcriptomic Portraits and Molecular Pathway Activation Features of Adult Spinal Intramedullary Astrocytomas.
RNA sequencing (RNA-seq)
gene expression
glioblastoma
molecular pathway activation
spinal cord neoplasms
spinal intramedullary astrocytoma
transcriptomic (RNA-Seq)
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2022
2022
Historique:
received:
16
12
2021
accepted:
21
02
2022
entrez:
7
4
2022
pubmed:
8
4
2022
medline:
8
4
2022
Statut:
epublish
Résumé
In this study, we report 31 spinal intramedullary astrocytoma (SIA) RNA sequencing (RNA-seq) profiles for 25 adult patients with documented clinical annotations. To our knowledge, this is the first clinically annotated RNA-seq dataset of spinal astrocytomas derived from the intradural intramedullary compartment. We compared these tumor profiles with the previous healthy central nervous system (CNS) RNA-seq data for spinal cord and brain and identified SIA-specific gene sets and molecular pathways. Our findings suggest a trend for SIA-upregulated pathways governing interactions with the immune cells and downregulated pathways for the neuronal functioning in the context of normal CNS activity. In two patient tumor biosamples, we identified diagnostic
Identifiants
pubmed: 35387112
doi: 10.3389/fonc.2022.837570
pmc: PMC8978956
doi:
Types de publication
Journal Article
Langues
eng
Pagination
837570Informations de copyright
Copyright © 2022 Konovalov, Timonin, Asyutin, Raevskiy, Sorokin, Buzdin and Kaprovoy.
Déclaration de conflit d'intérêts
Author MR was employed by Omicsway Corp and AB was employed by Omicsway Corp. and Oncobox Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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