The role of interleukin-17 in the pathogenesis of systemic sclerosis: Pro-fibrotic or anti-fibrotic?
Systemic sclerosis
T helper 17
fibroblast
fibrosis
interleukin-17
Journal
Journal of scleroderma and related disorders
ISSN: 2397-1991
Titre abrégé: J Scleroderma Relat Disord
Pays: England
ID NLM: 101685427
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
31
05
2021
accepted:
26
07
2021
entrez:
7
4
2022
pubmed:
8
4
2022
medline:
8
4
2022
Statut:
ppublish
Résumé
Systemic sclerosis is characterized by widespread fibrosis of the skin and internal organs, vascular impairment, and dysregulation of innate and adaptive immune system. Growing evidence indicates that T-cell proliferation and cytokine secretion play a major role in the initiation of systemic sclerosis, but the role of T helper 17 cells and of interleukin-17 cytokines in the development and progression of the disease remains controversial. In particular, an equally distributed body of literature supports both pro-fibrotic and anti-fibrotic effects of interleukin-17, suggesting a complex and nuanced role of this cytokine in systemic sclerosis pathogenesis that may vary depending on disease stage, target cells in affected organs, and inflammatory milieu. Although interleukin-17 already represents an established therapeutic target for several immune-mediated inflammatory diseases, more robust experimental evidence is required to clarify whether it may become an attractive therapeutic target for systemic sclerosis as well.
Identifiants
pubmed: 35387209
doi: 10.1177/23971983211039421
pii: 10.1177_23971983211039421
pmc: PMC8922653
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
227-235Informations de copyright
© The Author(s) 2021.
Déclaration de conflit d'intérêts
Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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