Assessments of prolonged effects of desflurane and sevoflurane on motor learning deficits in aged App
Alzheimer’s disease
AppNL−G−F/NL−G−F
Behavioral phenotype
General anesthesia
Postanesthetic effects
Transgenic mice
Journal
Molecular brain
ISSN: 1756-6606
Titre abrégé: Mol Brain
Pays: England
ID NLM: 101468876
Informations de publication
Date de publication:
07 04 2022
07 04 2022
Historique:
received:
01
12
2020
accepted:
16
03
2022
entrez:
7
4
2022
pubmed:
8
4
2022
medline:
9
4
2022
Statut:
epublish
Résumé
As the proportion of elderly in society increases, so do the number of older patients undergoing surgical procedures. This is concerning as exposure to anesthesia has been identified as a risk factor for Alzheimer's disease (AD). However, the causal relationship between clinical AD development and anesthesia remains conjectural. Preclinical studies have demonstrated that anesthesia, such as halothane, isoflurane, and sevoflurane, induces AD-like pathophysiological changes and cognitive impairments in transgenic mouse models of AD. Desflurane does not have these effects and is expected to have more potential for use in elderly patients, yet little is known about its effects, especially on non-cognitive functions, such as motor and emotional functions. Thus, we examined the postanesthetic effects of desflurane and sevoflurane on motor and emotional function in aged App
Identifiants
pubmed: 35387663
doi: 10.1186/s13041-022-00910-1
pii: 10.1186/s13041-022-00910-1
pmc: PMC8988377
doi:
Substances chimiques
Amyloid beta-Peptides
0
Amyloid beta-Protein Precursor
0
Sevoflurane
38LVP0K73A
Desflurane
CRS35BZ94Q
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
32Informations de copyright
© 2022. The Author(s).
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