Phylogeography and genomic epidemiology of SARS-CoV-2 in Italy and Europe with newly characterized Italian genomes between February-June 2020.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
06 04 2022
06 04 2022
Historique:
received:
29
07
2021
accepted:
25
03
2022
entrez:
7
4
2022
pubmed:
8
4
2022
medline:
9
4
2022
Statut:
epublish
Résumé
The aims of this study were to characterize new SARS-CoV-2 genomes sampled all over Italy and to reconstruct the origin and the evolutionary dynamics in Italy and Europe between February and June 2020. The cluster analysis showed only small clusters including < 80 Italian isolates, while most of the Italian strains were intermixed in the whole tree. Pure Italian clusters were observed mainly after the lockdown and distancing measures were adopted. Lineage B and B.1 spread between late January and early February 2020, from China to Veneto and Lombardy, respectively. Lineage B.1.1 (20B) most probably evolved within Italy and spread from central to south Italian regions, and to European countries. The lineage B.1.1.1 (20D) developed most probably in other European countries entering Italy only in the second half of March and remained localized in Piedmont until June 2020. In conclusion, within the limitations of phylogeographical reconstruction, the estimated ancestral scenario suggests an important role of China and Italy in the widespread diffusion of the D614G variant in Europe in the early phase of the pandemic and more dispersed exchanges involving several European countries from the second half of March 2020.
Identifiants
pubmed: 35388091
doi: 10.1038/s41598-022-09738-0
pii: 10.1038/s41598-022-09738-0
pmc: PMC8986836
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5736Investigateurs
Claudia Balotta
(C)
Carla Della Ventura
(CD)
Marco Schiuma
(M)
Enrico Lavezzo
(E)
Paolo Fontana
(P)
Luca Bianco
(L)
Luigi Bertolotti
(L)
Laura Manuto
(L)
Marco Grazioli
(M)
Federico Bianca
(F)
Claudia Del Vecchio
(C)
Elisa Franchin
(E)
Francesco Onelia
(F)
Andrea Spitaleri
(A)
Francesca Saluzzo
(F)
Giovanni Lorenzin
(G)
Stefano Pongolini
(S)
Erika Scaltriti
(E)
Laura Soliani
(L)
Patrizia Bagnarelli
(P)
Chiara Turchi
(C)
Valerio Onofri
(V)
Filomena Melchionda
(F)
Adriano Tagliabracci
(A)
Elisa Burdino
(E)
Maria Grazia Milia
(MG)
Patrizia Caligiuri
(P)
Vanessa De Pace
(V)
Valentina Ricucci
(V)
Alexander Domnich
(A)
Simona Boccotti
(S)
Leoni Maria Cristina
(LM)
Giuliana Lo Cascio
(GL)
Salvatore Rubino
(S)
Vincenzo Lai
(V)
Giulia Rocca
(G)
Rosalba Govoni
(R)
Giuseppe Mancuso
(G)
Roberta Campagna
(R)
Laura Mazzuti
(L)
Giuseppe Oliveto
(G)
Ombretta Turriziani
(O)
Laura Campogiani
(L)
Mirko Compagno
(M)
Luigi Coppola
(L)
Angela Maria Antonia Crea
(AMA)
Giuseppe De Simone
(G)
Andrea Di Lorenzo
(A)
Ludovica Ferrari
(L)
Marco Iannetta
(M)
Vincenzo Malagnino
(V)
Tiziana Mulas
(T)
Benedetta Rossi
(B)
Ilaria Spalliera
(I)
Simona Tedde
(S)
Elisabetta Teti
(E)
Pietro Vitale
(P)
Marta Zordan
(M)
Eugenio Milano
(E)
Antonella Lagioia
(A)
Rosa Gallitelli
(R)
Mario Starace
(M)
Carmine Minichini
(C)
Alessia Di Fraia
(A)
Maddalena Schioppa
(M)
Rita Greco
(R)
Anna Gidari
(A)
Maurizio Zazzi
(M)
Filippo Dragoni
(F)
Laura Li Puma
(LL)
Silvia Ronchiadin
(S)
Luigi Ruggerone
(L)
Dario Russignaga
(D)
Informations de copyright
© 2022. The Author(s).
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