Implanted System for Orthostatic Hypotension in Multiple-System Atrophy.

Accelerometry Atrophy Blood Pressure / physiology Electric Stimulation Therapy / methods Electrodes, Implanted Epidural Space Humans Hypotension, Orthostatic / diagnosis Multiple System Atrophy / therapy Posture / physiology Thoracic Vertebrae

Journal

The New England journal of medicine
ISSN: 1533-4406
Titre abrégé: N Engl J Med
Pays: United States
ID NLM: 0255562

Informations de publication

Date de publication:
07 04 2022
Historique:
entrez: 7 4 2022
pubmed: 8 4 2022
medline: 15 4 2022
Statut: ppublish

Résumé

Orthostatic hypotension is a cardinal feature of multiple-system atrophy. The upright posture provokes syncopal episodes that prevent patients from standing and walking for more than brief periods. We implanted a system to restore regulation of blood pressure and enable a patient with multiple-system atrophy to stand and walk after having lost these abilities because of orthostatic hypotension. This system involved epidural electrical stimulation delivered over the thoracic spinal cord with accelerometers that detected changes in body position. (Funded by the Defitech Foundation.).

Identifiants

DOI: 10.1056/NEJMoa2112809 PMID: 35388667
pubmed: 35388667
doi: 10.1056/NEJMoa2112809
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1339-1344

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2022 Massachusetts Medical Society.

Auteurs

Jordan W Squair (JW)

From the Center for Neuroprosthetics and the Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL) (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Department of Clinical Neuroscience (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Service of Neurosurgery (J.W.S., G.C., J.B.), the Service of Nephrology and Hypertension (M.B., G.W.), the Service of Neurology (M.C.J., J.F.B.), the Department of Diagnostic and Interventional Radiology (F.B.), and the Service of Anesthesiology (P.S.), Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Defitech Center for Interventional Neurotherapies (NeuroRestore), EPFL-CHUV-UNIL (J.W.S., M.B., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), and the Department of Nuclear Medicine and Molecular Imaging, CHUV (G.A.) - all in Lausanne, Switzerland.

Maxime Berney (M)

From the Center for Neuroprosthetics and the Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL) (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Department of Clinical Neuroscience (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Service of Neurosurgery (J.W.S., G.C., J.B.), the Service of Nephrology and Hypertension (M.B., G.W.), the Service of Neurology (M.C.J., J.F.B.), the Department of Diagnostic and Interventional Radiology (F.B.), and the Service of Anesthesiology (P.S.), Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Defitech Center for Interventional Neurotherapies (NeuroRestore), EPFL-CHUV-UNIL (J.W.S., M.B., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), and the Department of Nuclear Medicine and Molecular Imaging, CHUV (G.A.) - all in Lausanne, Switzerland.

Mayte Castro Jimenez (M)

From the Center for Neuroprosthetics and the Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL) (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Department of Clinical Neuroscience (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Service of Neurosurgery (J.W.S., G.C., J.B.), the Service of Nephrology and Hypertension (M.B., G.W.), the Service of Neurology (M.C.J., J.F.B.), the Department of Diagnostic and Interventional Radiology (F.B.), and the Service of Anesthesiology (P.S.), Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Defitech Center for Interventional Neurotherapies (NeuroRestore), EPFL-CHUV-UNIL (J.W.S., M.B., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), and the Department of Nuclear Medicine and Molecular Imaging, CHUV (G.A.) - all in Lausanne, Switzerland.
ORCID: 0000-0003-4165-4804

Nicolas Hankov (N)

From the Center for Neuroprosthetics and the Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL) (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Department of Clinical Neuroscience (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Service of Neurosurgery (J.W.S., G.C., J.B.), the Service of Nephrology and Hypertension (M.B., G.W.), the Service of Neurology (M.C.J., J.F.B.), the Department of Diagnostic and Interventional Radiology (F.B.), and the Service of Anesthesiology (P.S.), Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Defitech Center for Interventional Neurotherapies (NeuroRestore), EPFL-CHUV-UNIL (J.W.S., M.B., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), and the Department of Nuclear Medicine and Molecular Imaging, CHUV (G.A.) - all in Lausanne, Switzerland.

Robin Demesmaeker (R)

From the Center for Neuroprosthetics and the Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL) (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Department of Clinical Neuroscience (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Service of Neurosurgery (J.W.S., G.C., J.B.), the Service of Nephrology and Hypertension (M.B., G.W.), the Service of Neurology (M.C.J., J.F.B.), the Department of Diagnostic and Interventional Radiology (F.B.), and the Service of Anesthesiology (P.S.), Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Defitech Center for Interventional Neurotherapies (NeuroRestore), EPFL-CHUV-UNIL (J.W.S., M.B., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), and the Department of Nuclear Medicine and Molecular Imaging, CHUV (G.A.) - all in Lausanne, Switzerland.

Suje Amir (S)

From the Center for Neuroprosthetics and the Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL) (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Department of Clinical Neuroscience (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Service of Neurosurgery (J.W.S., G.C., J.B.), the Service of Nephrology and Hypertension (M.B., G.W.), the Service of Neurology (M.C.J., J.F.B.), the Department of Diagnostic and Interventional Radiology (F.B.), and the Service of Anesthesiology (P.S.), Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Defitech Center for Interventional Neurotherapies (NeuroRestore), EPFL-CHUV-UNIL (J.W.S., M.B., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), and the Department of Nuclear Medicine and Molecular Imaging, CHUV (G.A.) - all in Lausanne, Switzerland.

Aurelie Paley (A)

From the Center for Neuroprosthetics and the Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL) (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Department of Clinical Neuroscience (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Service of Neurosurgery (J.W.S., G.C., J.B.), the Service of Nephrology and Hypertension (M.B., G.W.), the Service of Neurology (M.C.J., J.F.B.), the Department of Diagnostic and Interventional Radiology (F.B.), and the Service of Anesthesiology (P.S.), Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Defitech Center for Interventional Neurotherapies (NeuroRestore), EPFL-CHUV-UNIL (J.W.S., M.B., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), and the Department of Nuclear Medicine and Molecular Imaging, CHUV (G.A.) - all in Lausanne, Switzerland.

Sergio Hernandez-Charpak (S)

From the Center for Neuroprosthetics and the Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL) (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Department of Clinical Neuroscience (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Service of Neurosurgery (J.W.S., G.C., J.B.), the Service of Nephrology and Hypertension (M.B., G.W.), the Service of Neurology (M.C.J., J.F.B.), the Department of Diagnostic and Interventional Radiology (F.B.), and the Service of Anesthesiology (P.S.), Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Defitech Center for Interventional Neurotherapies (NeuroRestore), EPFL-CHUV-UNIL (J.W.S., M.B., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), and the Department of Nuclear Medicine and Molecular Imaging, CHUV (G.A.) - all in Lausanne, Switzerland.
ORCID: 0000-0003-0477-8138

Gregory Dumont (G)

From the Center for Neuroprosthetics and the Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL) (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Department of Clinical Neuroscience (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Service of Neurosurgery (J.W.S., G.C., J.B.), the Service of Nephrology and Hypertension (M.B., G.W.), the Service of Neurology (M.C.J., J.F.B.), the Department of Diagnostic and Interventional Radiology (F.B.), and the Service of Anesthesiology (P.S.), Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Defitech Center for Interventional Neurotherapies (NeuroRestore), EPFL-CHUV-UNIL (J.W.S., M.B., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), and the Department of Nuclear Medicine and Molecular Imaging, CHUV (G.A.) - all in Lausanne, Switzerland.

Leonie Asboth (L)

From the Center for Neuroprosthetics and the Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL) (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Department of Clinical Neuroscience (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Service of Neurosurgery (J.W.S., G.C., J.B.), the Service of Nephrology and Hypertension (M.B., G.W.), the Service of Neurology (M.C.J., J.F.B.), the Department of Diagnostic and Interventional Radiology (F.B.), and the Service of Anesthesiology (P.S.), Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Defitech Center for Interventional Neurotherapies (NeuroRestore), EPFL-CHUV-UNIL (J.W.S., M.B., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), and the Department of Nuclear Medicine and Molecular Imaging, CHUV (G.A.) - all in Lausanne, Switzerland.

Gilles Allenbach (G)

From the Center for Neuroprosthetics and the Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL) (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Department of Clinical Neuroscience (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Service of Neurosurgery (J.W.S., G.C., J.B.), the Service of Nephrology and Hypertension (M.B., G.W.), the Service of Neurology (M.C.J., J.F.B.), the Department of Diagnostic and Interventional Radiology (F.B.), and the Service of Anesthesiology (P.S.), Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Defitech Center for Interventional Neurotherapies (NeuroRestore), EPFL-CHUV-UNIL (J.W.S., M.B., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), and the Department of Nuclear Medicine and Molecular Imaging, CHUV (G.A.) - all in Lausanne, Switzerland.

Fabio Becce (F)

From the Center for Neuroprosthetics and the Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL) (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Department of Clinical Neuroscience (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Service of Neurosurgery (J.W.S., G.C., J.B.), the Service of Nephrology and Hypertension (M.B., G.W.), the Service of Neurology (M.C.J., J.F.B.), the Department of Diagnostic and Interventional Radiology (F.B.), and the Service of Anesthesiology (P.S.), Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Defitech Center for Interventional Neurotherapies (NeuroRestore), EPFL-CHUV-UNIL (J.W.S., M.B., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), and the Department of Nuclear Medicine and Molecular Imaging, CHUV (G.A.) - all in Lausanne, Switzerland.
ORCID: 0000-0001-8444-8504

Patrick Schoettker (P)

From the Center for Neuroprosthetics and the Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL) (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Department of Clinical Neuroscience (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Service of Neurosurgery (J.W.S., G.C., J.B.), the Service of Nephrology and Hypertension (M.B., G.W.), the Service of Neurology (M.C.J., J.F.B.), the Department of Diagnostic and Interventional Radiology (F.B.), and the Service of Anesthesiology (P.S.), Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Defitech Center for Interventional Neurotherapies (NeuroRestore), EPFL-CHUV-UNIL (J.W.S., M.B., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), and the Department of Nuclear Medicine and Molecular Imaging, CHUV (G.A.) - all in Lausanne, Switzerland.

Gregoire Wuerzner (G)

From the Center for Neuroprosthetics and the Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL) (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Department of Clinical Neuroscience (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Service of Neurosurgery (J.W.S., G.C., J.B.), the Service of Nephrology and Hypertension (M.B., G.W.), the Service of Neurology (M.C.J., J.F.B.), the Department of Diagnostic and Interventional Radiology (F.B.), and the Service of Anesthesiology (P.S.), Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Defitech Center for Interventional Neurotherapies (NeuroRestore), EPFL-CHUV-UNIL (J.W.S., M.B., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), and the Department of Nuclear Medicine and Molecular Imaging, CHUV (G.A.) - all in Lausanne, Switzerland.

Julien F Bally (JF)

From the Center for Neuroprosthetics and the Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL) (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Department of Clinical Neuroscience (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Service of Neurosurgery (J.W.S., G.C., J.B.), the Service of Nephrology and Hypertension (M.B., G.W.), the Service of Neurology (M.C.J., J.F.B.), the Department of Diagnostic and Interventional Radiology (F.B.), and the Service of Anesthesiology (P.S.), Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Defitech Center for Interventional Neurotherapies (NeuroRestore), EPFL-CHUV-UNIL (J.W.S., M.B., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), and the Department of Nuclear Medicine and Molecular Imaging, CHUV (G.A.) - all in Lausanne, Switzerland.

Grégoire Courtine (G)

From the Center for Neuroprosthetics and the Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL) (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Department of Clinical Neuroscience (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Service of Neurosurgery (J.W.S., G.C., J.B.), the Service of Nephrology and Hypertension (M.B., G.W.), the Service of Neurology (M.C.J., J.F.B.), the Department of Diagnostic and Interventional Radiology (F.B.), and the Service of Anesthesiology (P.S.), Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Defitech Center for Interventional Neurotherapies (NeuroRestore), EPFL-CHUV-UNIL (J.W.S., M.B., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), and the Department of Nuclear Medicine and Molecular Imaging, CHUV (G.A.) - all in Lausanne, Switzerland.

Jocelyne Bloch (J)

From the Center for Neuroprosthetics and the Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL) (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Department of Clinical Neuroscience (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Service of Neurosurgery (J.W.S., G.C., J.B.), the Service of Nephrology and Hypertension (M.B., G.W.), the Service of Neurology (M.C.J., J.F.B.), the Department of Diagnostic and Interventional Radiology (F.B.), and the Service of Anesthesiology (P.S.), Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Defitech Center for Interventional Neurotherapies (NeuroRestore), EPFL-CHUV-UNIL (J.W.S., M.B., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), and the Department of Nuclear Medicine and Molecular Imaging, CHUV (G.A.) - all in Lausanne, Switzerland.

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Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Accélérométrie › Implanted System for Orthostatic Hypotension...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Atrophie › Implanted System for Orthostatic Hypotension...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Pression sanguine › Implanted System for Orthostatic Hypotension...
questionsmedicales.fr › Thérapeutique › Techniques de physiothérapie › Électrothérapie › Implanted System for Orthostatic Hypotension...
questionsmedicales.fr › Équipement et fournitures › Prothèses et implants › Électrodes implantées › Implanted System for Orthostatic Hypotension...
questionsmedicales.fr › Appareil locomoteur › Squelette › Rachis › Canal vertébral › Espace épidural › Implanted System for Orthostatic Hypotension...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Implanted System for Orthostatic Hypotension...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Hypotension artérielle › Hypotension orthostatique › Implanted System for Orthostatic Hypotension...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Atrophie multisystématisée › Implanted System for Orthostatic Hypotension...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Posture › Implanted System for Orthostatic Hypotension...
questionsmedicales.fr › Appareil locomoteur › Squelette › Rachis › Vertèbres thoraciques › Implanted System for Orthostatic Hypotension...