Albumin, oral contraceptives, and venous thromboembolism risk in astronauts.


Journal

Journal of applied physiology (Bethesda, Md. : 1985)
ISSN: 1522-1601
Titre abrégé: J Appl Physiol (1985)
Pays: United States
ID NLM: 8502536

Informations de publication

Date de publication:
01 05 2022
Historique:
pubmed: 8 4 2022
medline: 20 5 2022
entrez: 7 4 2022
Statut: ppublish

Résumé

A venous thromboembolism (VTE) event occurred in a female astronaut during long-duration spaceflight. Multiple factors may have contributed to this risk, including the use of combined (progestin + estrogen) oral contraceptives (cOC). Biochemistry data from 65 astronauts were evaluated for associations with cOC use and with sex. The female astronauts who used cOCs had lower concentrations of serum albumin and higher concentrations of transferrin, a protein involved in the clotting cascade, than the male astronauts and the female astronauts who were not taking cOCs (

Identifiants

pubmed: 35389755
doi: 10.1152/japplphysiol.00024.2022
pmc: PMC9126217
doi:

Substances chimiques

Contraceptives, Oral, Combined 0
Serum Albumin 0
Transferrins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1232-1239

Subventions

Organisme : NASA | Johnson Space Center (JSC)

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Auteurs

Sara R Zwart (SR)

The University of Texas Medical Branch, Galveston, Texas.

Serena M Auñón-Chancellor (SM)

The University of Texas Medical Branch, Galveston, Texas.
Louisiana State University Health New Orleans School of Medicine, Baton Rouge, Louisiana.
NASA Johnson Space Center, Houston, Texas.

Martina Heer (M)

IU International University of Applied Sciences and Institute of Nutritional and Food Sciences, University of Bonn, Bonn, Germany.

M Mark Melin (MM)

M Health Fairview, University of Minnesota Physicians, Edina, Minnesota.

Scott M Smith (SM)

NASA Johnson Space Center, Houston, Texas.

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Classifications MeSH