Cytotoxicity reduction by O-nicotinoylation of antiviral 6-benzylaminopurine ribonucleosides.
6-Benzylaminopurine ribonucleosides
Antiviral activity
Biodegradable lipophilic groups
Cytotoxicity reduction
Enterovirus EV-A71
O-Nicotinoylation
Journal
Toxicology in vitro : an international journal published in association with BIBRA
ISSN: 1879-3177
Titre abrégé: Toxicol In Vitro
Pays: England
ID NLM: 8712158
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
received:
17
01
2022
accepted:
30
03
2022
pubmed:
8
4
2022
medline:
7
6
2022
entrez:
7
4
2022
Statut:
ppublish
Résumé
One of the promising approaches in the development of nucleoside prodrugs is to use the nucleoside analogs containing lipophilic biodegradable residues, which are cleaved to biologically active forms after metabolic transformations in the cell. The introduction of such fragments makes it possible to reduce the general toxicity of the drug candidate and increase its stability in the cell. In order to study the influence of biodegradable lipophilic groups on antiviral activity and cytotoxicity, in this work we synthesized N
Identifiants
pubmed: 35390475
pii: S0887-2333(22)00052-2
doi: 10.1016/j.tiv.2022.105355
pii:
doi:
Substances chimiques
Antiviral Agents
0
Benzyl Compounds
0
Nucleosides
0
Prodrugs
0
Purines
0
Ribonucleosides
0
Adenosine
K72T3FS567
benzylaminopurine
KXG6A989PS
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105355Informations de copyright
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