Polycyclic Aromatic Hydrocarbons Affect Rheumatoid Arthritis Pathogenesis
aryl hydrocarbon receptor
aryl hydrocarbon receptor repressor
particulate matter
polycyclic aromatic hydrocarbons
rheumatoid arthritis
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
19
10
2021
accepted:
28
02
2022
entrez:
8
4
2022
pubmed:
9
4
2022
medline:
12
4
2022
Statut:
epublish
Résumé
Rheumatoid arthritis (RA), the most common autoimmune disease, is characterized by symmetrical synovial inflammation of multiple joints with the infiltration of pro-inflammatory immune cells and increased cytokines (CKs) levels. In the past few years, numerous studies have indicated that several factors could affect RA, such as mutations in susceptibility genes, epigenetic modifications, age, and race. Recently, environmental factors, particularly polycyclic aromatic hydrocarbons (PAHs), have attracted increasing attention in RA pathogenesis. Therefore, exploring the specific mechanisms of PAHs in RA is vitally critical. In this review, we summarize the recent progress in understanding the mechanisms of PAHs and aryl hydrocarbon receptors (AHRs) in RA. Additionally, the development of therapeutic drugs that target AHR is also reviewed. Finally, we discuss the challenges and perspectives on AHR application in the future.
Identifiants
pubmed: 35392076
doi: 10.3389/fimmu.2022.797815
pmc: PMC8981517
doi:
Substances chimiques
Polycyclic Aromatic Hydrocarbons
0
Receptors, Aryl Hydrocarbon
0
Types de publication
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
797815Informations de copyright
Copyright © 2022 Xi, Ye, Fan, Cao, Wang, Wang, Zhang, Xu and Xiao.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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