Exome and Tissue-Associated Microbiota as Predictive Markers of Response to Neoadjuvant Treatment in Locally Advanced Rectal Cancer.
biomarkers of treatment response
locally advanced rectal cancer
microbiota
mutational signatures
neoadjuvant chemoradiotherapy
whole exome sequencing
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2022
2022
Historique:
received:
05
11
2021
accepted:
17
02
2022
entrez:
8
4
2022
pubmed:
9
4
2022
medline:
9
4
2022
Statut:
epublish
Résumé
The clinical and pathological responses to multimodal neoadjuvant therapy in locally advanced rectal cancers (LARCs) remain unpredictable, and robust biomarkers are still lacking. Recent studies have shown that tumors present somatic molecular alterations related to better treatment response, and it is also clear that tumor-associated bacteria are modulators of chemotherapy and immunotherapy efficacy, therefore having implications for long-term survivorship and a good potential as the biomarkers of outcome. Here, we performed whole exome sequencing and 16S ribosomal RNA (rRNA) amplicon sequencing from 44 pre-treatment LARC biopsies from Argentinian and Brazilian patients, treated with neoadjuvant chemoradiotherapy or total neoadjuvant treatment, searching for predictive biomarkers of response (responders,
Identifiants
pubmed: 35392220
doi: 10.3389/fonc.2022.809441
pmc: PMC8982181
doi:
Types de publication
Journal Article
Langues
eng
Pagination
809441Informations de copyright
Copyright © 2022 Takenaka, Bartelli, Defelicibus, Sendoya, Golubicki, Robbio, Serpa, Branco, Santos, Claro, dos Santos, Kupper, da Silva, Llera, de Mello, Riechelmann, Dias-Neto, Iseas, Aguiar and Nunes.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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