Clustering of lung diseases in the family of interstitial lung disease patients.
Family research
Interstitial
Lung diseases
Pulmonary fibrosis
Journal
BMC pulmonary medicine
ISSN: 1471-2466
Titre abrégé: BMC Pulm Med
Pays: England
ID NLM: 100968563
Informations de publication
Date de publication:
07 Apr 2022
07 Apr 2022
Historique:
received:
02
12
2021
accepted:
31
03
2022
entrez:
8
4
2022
pubmed:
9
4
2022
medline:
12
4
2022
Statut:
epublish
Résumé
The presence of familial interstitial lung disease (ILD) has been found to predict development of progressive pulmonary fibrosis. However, the role of non-ILD lung diseases in ILD patients' families has not yet been investigated. We aimed to identify associations between ILDs and non-ILD lung diseases from ILD patients' self-reported family health history. We analysed questionnaires on family health history of 1164 ILD patients for the occurrence of ILD and non-ILD lung disease in relatives. Logistic regression analysis was used to study associations with diagnosis groups. Familial pulmonary fibrosis was reported by 20% of patients with idiopathic pulmonary fibrosis (IPF; OR 9.2, 95% CI 4.7-17.9), and 15% of patients with unclassifiable pulmonary fibrosis (OR 4.1, 95% CI 2.0-8.2). Familial occurrence was reported by 14% of patients with sarcoidosis (OR 3.3, 95% CI 1.9-5.8). Regarding non-ILD lung disease, significantly more patients with IPF (36%) reported lung cancer in their family (OR 2.3, 95% CI 1.4-3.5), and patients with hypersensitivity pneumonitis (18%) mostly reported COPD (OR 2.3, 95% CI 1.3-4.2). Comparison of sporadic and familial ILD patients' reports showed that emphysema (OR 4.6, 95% CI 1.8-11.6), and lung cancer (OR 2.4, 95% CI 1.2-4.9) were predictive for familial pulmonary fibrosis, particularly when reported both in a family (OR 16.7, 95% CI 3.2-86.6; p < 0.001). Our findings provide evidence for clustering of ILD and non-ILD lung diseases in families and show that self-reported emphysema and lung cancer of relatives in this population predicts familial pulmonary fibrosis.
Sections du résumé
BACKGROUND
BACKGROUND
The presence of familial interstitial lung disease (ILD) has been found to predict development of progressive pulmonary fibrosis. However, the role of non-ILD lung diseases in ILD patients' families has not yet been investigated. We aimed to identify associations between ILDs and non-ILD lung diseases from ILD patients' self-reported family health history.
METHODS
METHODS
We analysed questionnaires on family health history of 1164 ILD patients for the occurrence of ILD and non-ILD lung disease in relatives. Logistic regression analysis was used to study associations with diagnosis groups.
RESULTS
RESULTS
Familial pulmonary fibrosis was reported by 20% of patients with idiopathic pulmonary fibrosis (IPF; OR 9.2, 95% CI 4.7-17.9), and 15% of patients with unclassifiable pulmonary fibrosis (OR 4.1, 95% CI 2.0-8.2). Familial occurrence was reported by 14% of patients with sarcoidosis (OR 3.3, 95% CI 1.9-5.8). Regarding non-ILD lung disease, significantly more patients with IPF (36%) reported lung cancer in their family (OR 2.3, 95% CI 1.4-3.5), and patients with hypersensitivity pneumonitis (18%) mostly reported COPD (OR 2.3, 95% CI 1.3-4.2). Comparison of sporadic and familial ILD patients' reports showed that emphysema (OR 4.6, 95% CI 1.8-11.6), and lung cancer (OR 2.4, 95% CI 1.2-4.9) were predictive for familial pulmonary fibrosis, particularly when reported both in a family (OR 16.7, 95% CI 3.2-86.6; p < 0.001).
CONCLUSIONS
CONCLUSIONS
Our findings provide evidence for clustering of ILD and non-ILD lung diseases in families and show that self-reported emphysema and lung cancer of relatives in this population predicts familial pulmonary fibrosis.
Identifiants
pubmed: 35392870
doi: 10.1186/s12890-022-01927-x
pii: 10.1186/s12890-022-01927-x
pmc: PMC8991662
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
134Informations de copyright
© 2022. The Author(s).
Références
Nat Rev Rheumatol. 2016 Jun;12(6):335-43
pubmed: 27098907
Am J Respir Crit Care Med. 2010 Dec 1;182(11):1419-25
pubmed: 20656946
Thorax. 2002 Apr;57(4):338-42
pubmed: 11923553
Am J Respir Crit Care Med. 2007 Oct 1;176(7):698-705
pubmed: 17641157
J Autoimmun. 2009 Nov-Dec;33(3-4):197-207
pubmed: 19819109
Am J Respir Crit Care Med. 2021 Feb 1;203(3):339-347
pubmed: 32692582
J Biomed Inform. 2019 Jul;95:103208
pubmed: 31078660
Eur Respir Rev. 2021 Feb 16;30(159):
pubmed: 33597124
BMC Pulm Med. 2019 Jul 18;19(1):130
pubmed: 31319833
Am J Respir Crit Care Med. 2020 May 15;201(10):1240-1248
pubmed: 32011908
J Biomed Inform. 2009 Apr;42(2):377-81
pubmed: 18929686
Am J Respir Crit Care Med. 2020 Aug 1;202(3):e36-e69
pubmed: 32706311
Lancet. 2019 Aug 17;394(10198):596-603
pubmed: 31395442
Arch Pathol Lab Med. 2012 Nov;136(11):1366-76
pubmed: 23106582
Curr Opin Pulm Med. 2018 May;24(3):269-280
pubmed: 29474209
Br J Cancer. 2004 Aug;91 Suppl 2:S3-10
pubmed: 15340372
Respirology. 2016 May;21(4):712-7
pubmed: 26699835
Am J Respir Crit Care Med. 2001 Dec 1;164(11):2085-91
pubmed: 11739139
Respir Med. 2012 Apr;106(4):588-93
pubmed: 22296740
Chest. 2005 Jun;127(6):2034-41
pubmed: 15947317
BMC Med. 2013 Mar 18;11:73
pubmed: 23497011
Am J Respir Crit Care Med. 2020 May 15;201(10):1230-1239
pubmed: 32011901
Curr Opin Pulm Med. 2018 May;24(3):309-317
pubmed: 29517586
Eur Respir J. 2016 Dec;48(6):1710-1720
pubmed: 27540018
Eur Respir J. 2018 Jun 14;51(6):
pubmed: 29724923
Am J Respir Crit Care Med. 2005 Nov 1;172(9):1146-52
pubmed: 16109978
Respir Med. 2011 Dec;105(12):1902-7
pubmed: 21917441
Chest. 2021 May;159(5):1913-1921
pubmed: 33484728
Curr Opin Pulm Med. 2019 Sep;25(5):539-553
pubmed: 31365389
Eur Respir Rev. 2019 Sep 25;28(153):
pubmed: 31554702
Eur Respir Rev. 2014 Mar 1;23(131):40-54
pubmed: 24591661
Biomark Med. 2020 Jul;14(11):997-1007
pubmed: 32940077
Eur Respir J. 2015 Oct;46(4):976-87
pubmed: 26160873
Am J Respir Crit Care Med. 2018 Sep 1;198(5):e44-e68
pubmed: 30168753
Chest. 2020 Aug;158(2):612-619
pubmed: 32315675
Eur Respir Rev. 2018 Dec 21;27(150):
pubmed: 30578335
Chest. 2012 Dec;142(6):1577-1583
pubmed: 23364926
Am J Respir Crit Care Med. 2020 Apr 15;201(8):e26-e51
pubmed: 32293205
Eur Respir Rev. 2017 Apr 26;26(144):
pubmed: 28446600
Am J Respir Crit Care Med. 2013 Sep 15;188(6):733-48
pubmed: 24032382
Lancet Respir Med. 2017 Dec;5(12):946-955
pubmed: 29150411
PLoS One. 2010 May 19;5(5):e10680
pubmed: 20502709
Am J Respir Crit Care Med. 2019 Jul 15;200(2):199-208
pubmed: 31034279
Am J Respir Crit Care Med. 2015 Feb 15;191(4):417-26
pubmed: 25389906
Sci Rep. 2021 Jan 28;11(1):2596
pubmed: 33510351