Obesity I: Overview and molecular and biochemical mechanisms.
Adipose tissue
Energy balance
Hormone receptors
Metabolism
Microbiome
Obesity
Journal
Biochemical pharmacology
ISSN: 1873-2968
Titre abrégé: Biochem Pharmacol
Pays: England
ID NLM: 0101032
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
received:
08
12
2021
revised:
12
03
2022
accepted:
15
03
2022
pubmed:
9
4
2022
medline:
29
4
2022
entrez:
8
4
2022
Statut:
ppublish
Résumé
Obesity is a chronic, relapsing condition characterized by excess body fat. Its prevalence has increased globally since the 1970s, and the number of obese and overweight people is now greater than those underweight. Obesity is a multifactorial condition, and as such, many components contribute to its development and pathogenesis. This is the first of three companion reviews that consider obesity. This review focuses on the genetics, viruses, insulin resistance, inflammation, gut microbiome, and circadian rhythms that promote obesity, along with hormones, growth factors, and organs and tissues that control its development. It shows that the regulation of energy balance (intake vs. expenditure) relies on the interplay of a variety of hormones from adipose tissue, gastrointestinal tract, pancreas, liver, and brain. It details how integrating central neurotransmitters and peripheral metabolic signals (e.g., leptin, insulin, ghrelin, peptide YY
Identifiants
pubmed: 35393120
pii: S0006-2952(22)00106-X
doi: 10.1016/j.bcp.2022.115012
pmc: PMC9050949
mid: NIHMS1794262
pii:
doi:
Substances chimiques
Insulin
0
Leptin
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
115012Subventions
Organisme : NIEHS NIH HHS
ID : P30 ES025128
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES030283
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK063720
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES005022
Pays : United States
Organisme : NIEHS NIH HHS
ID : P01 ES028942
Pays : United States
Organisme : NIEHS NIH HHS
ID : T32 ES011564
Pays : United States
Organisme : NIEHS NIH HHS
ID : R21 ES031510
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES032189
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM103641
Pays : United States
Organisme : NCCIH NIH HHS
ID : P01 AT003961
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH123544
Pays : United States
Organisme : NIEHS NIH HHS
ID : R00 ES030405
Pays : United States
Organisme : NIEHS NIH HHS
ID : R35 ES028373
Pays : United States
Organisme : NIEHS NIH HHS
ID : P42 ES023716
Pays : United States
Informations de copyright
Crown Copyright © 2022. Published by Elsevier Inc. All rights reserved.
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