Functional and structural deficiencies of Gemin5 variants associated with neurological disorders.


Journal

Life science alliance
ISSN: 2575-1077
Titre abrégé: Life Sci Alliance
Pays: United States
ID NLM: 101728869

Informations de publication

Date de publication:
07 2022
Historique:
received: 10 02 2022
revised: 21 03 2022
accepted: 22 03 2022
entrez: 8 4 2022
pubmed: 9 4 2022
medline: 12 4 2022
Statut: epublish

Résumé

Dysfunction of RNA-binding proteins is often linked to a wide range of human disease, particularly with neurological conditions. Gemin5 is a member of the survival of the motor neurons (SMN) complex, a ribosome-binding protein and a translation reprogramming factor. Recently, pathogenic mutations in

Identifiants

pubmed: 35393353
pii: 5/7/e202201403
doi: 10.26508/lsa.202201403
pmc: PMC8989681
pii:
doi:

Substances chimiques

GEMIN5 protein, human 0
RNA-Binding Proteins 0
SMN Complex Proteins 0
RNA 63231-63-0

Banques de données

GENBANK
['NM_015465.4', 'NM_015465.5']

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2022 Francisco-Velilla et al.

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Auteurs

Rosario Francisco-Velilla (R)

Centro de Biología Molecular Severo Ochoa (CBMSO), Consejo Superior de Investigaciones Cientificas - Universidad Autónoma de Madrid (CSIC-UAM), Madrid, Spain.

Azman Embarc-Buh (A)

Centro de Biología Molecular Severo Ochoa (CBMSO), Consejo Superior de Investigaciones Cientificas - Universidad Autónoma de Madrid (CSIC-UAM), Madrid, Spain.

Francisco Del Caño-Ochoa (F)

Instituto de Biomedicina de Valencia (IBV-CSIC), Valencia, Spain.
Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.

Salvador Abellan (S)

Centro de Biología Molecular Severo Ochoa (CBMSO), Consejo Superior de Investigaciones Cientificas - Universidad Autónoma de Madrid (CSIC-UAM), Madrid, Spain.

Marçal Vilar (M)

Instituto de Biomedicina de Valencia (IBV-CSIC), Valencia, Spain.

Sara Alvarez (S)

New Integrated Medical Genetics (NIMGENETICS), Madrid, Spain.

Alberto Fernandez-Jaen (A)

Neuropediatric Department, Hospital Universitario Quirónsalud, Madrid, Spain.
School of Medicine, Universidad Europea de Madrid, Madrid, Spain.

Sukhleen Kour (S)

Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Deepa S Rajan (DS)

Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Udai Bhan Pandey (UB)

Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Santiago Ramón-Maiques (S)

Instituto de Biomedicina de Valencia (IBV-CSIC), Valencia, Spain.
Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.

Encarnacion Martinez-Salas (E)

Centro de Biología Molecular Severo Ochoa (CBMSO), Consejo Superior de Investigaciones Cientificas - Universidad Autónoma de Madrid (CSIC-UAM), Madrid, Spain emartinez@cbm.csic.es.

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Classifications MeSH