Carbamazepine induces upward frequency shifts of spontaneous otoacoustic emissions.
Carbamazepine
Cochlear partition
Pitch perception
Spontaneous otoacoustic emissions
Journal
Hearing research
ISSN: 1878-5891
Titre abrégé: Hear Res
Pays: Netherlands
ID NLM: 7900445
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
16
11
2021
revised:
14
03
2022
accepted:
23
03
2022
pubmed:
9
4
2022
medline:
7
6
2022
entrez:
8
4
2022
Statut:
ppublish
Résumé
In three subjects, we measured spontaneous otoacoustic emissions (SOAEs) when they were using carbamazepine (CBZ), and compared this to the SOAE measurement when they were not using CBZ. We observed 14 SOAEs showing a consistent upward shift of center frequency, related to CBZ intake. On average, the magnitude of the frequency shift increased with increasing frequency. The magnitude of the shift was 30-104 Hz, at frequencies ranging from 1.3 to 2.3 kHz, corresponding to a shift between 2.3 and 4.5%. Compared to other causes and manipulations known to change SOAE frequency, these shifts are relatively large. The underlying mechanism is most likely an increased stiffness of the cochlear partition. This would also explain the downward pitch shift due to CBZ, which has been reported by subjects with absolute pitch.
Identifiants
pubmed: 35395509
pii: S0378-5955(22)00063-6
doi: 10.1016/j.heares.2022.108492
pii:
doi:
Substances chimiques
Carbamazepine
33CM23913M
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
108492Informations de copyright
Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare no competing financial interests.