Association between platelet, white blood cell count, platelet to white blood cell ratio and sarcopenia in community-dwelling older adults: focus on Bushehr Elderly Health (BEH) program.
Chronic inflammation
Older adults
Platelet
Platelet to white blood cell ratio
Sarcopenia
White blood cell
Journal
BMC geriatrics
ISSN: 1471-2318
Titre abrégé: BMC Geriatr
Pays: England
ID NLM: 100968548
Informations de publication
Date de publication:
08 04 2022
08 04 2022
Historique:
received:
09
09
2021
accepted:
17
03
2022
entrez:
9
4
2022
pubmed:
10
4
2022
medline:
13
4
2022
Statut:
epublish
Résumé
Sarcopenia is a progressive age-related skeletal muscle disorder associated with harmful impacts on health. The present study aimed to investigate the relation between sarcopenia, platelet (PLT), white blood cell (WBC), and PLT to WBC ratio (PWR) due to the importance of early sarcopenia diagnosis. This cross-sectional study was conducted based on the second stage of the Bushehr Elderly Health (BEH) Program. Sarcopenia was defined based on the revised edition of the European Working Group on Sarcopenia in Older People (EWGSOP2) in accordance with the Iranian cut-off point. Univariate and adjusted multivariate logistic regression and linear regression were used to evaluate the associations. The prevalence of sarcopenia among participants was 35.73%. PLT count and PWR were statistically higher in severe sarcopenic participants, while no differences were seen in WBC. In crude analysis, sarcopenia was not associated with quartiles of PLT, WBC, and PWR, while after adjusting for age, marital status, and sex, the association was seen in the fourth quartile of PLT and PWR [OR (95%CI) = 1.40 (1.08 to 1.81), p-value = 0.009 for PLT; OR (95%CI) =1.55 (1.20 to 2.00), p-value =0.001 for PWR]. This association remained significant in the fully adjusted model [OR (95%CI) =1.82 (1.20 to 2.78), p-value =0.005 for PLT; OR (95%CI) =1.57 (1.03 to 2.40), p-value =0.035 for PWR]. Among sarcopenia parameters, PLT count was more likely to be associated with handgrip strength and muscle mass. After stratifying the participants by gender, sarcopenia parameters were no longer statistically significant in men. This study showed that PLT and PWR were associated with sarcopenia after considering confounding factors, while this association was not seen in WBC. Moreover, results showed that gender had an important impact on sarcopenia parameters.
Sections du résumé
BACKGROUND
Sarcopenia is a progressive age-related skeletal muscle disorder associated with harmful impacts on health. The present study aimed to investigate the relation between sarcopenia, platelet (PLT), white blood cell (WBC), and PLT to WBC ratio (PWR) due to the importance of early sarcopenia diagnosis.
METHODS
This cross-sectional study was conducted based on the second stage of the Bushehr Elderly Health (BEH) Program. Sarcopenia was defined based on the revised edition of the European Working Group on Sarcopenia in Older People (EWGSOP2) in accordance with the Iranian cut-off point. Univariate and adjusted multivariate logistic regression and linear regression were used to evaluate the associations.
RESULTS
The prevalence of sarcopenia among participants was 35.73%. PLT count and PWR were statistically higher in severe sarcopenic participants, while no differences were seen in WBC. In crude analysis, sarcopenia was not associated with quartiles of PLT, WBC, and PWR, while after adjusting for age, marital status, and sex, the association was seen in the fourth quartile of PLT and PWR [OR (95%CI) = 1.40 (1.08 to 1.81), p-value = 0.009 for PLT; OR (95%CI) =1.55 (1.20 to 2.00), p-value =0.001 for PWR]. This association remained significant in the fully adjusted model [OR (95%CI) =1.82 (1.20 to 2.78), p-value =0.005 for PLT; OR (95%CI) =1.57 (1.03 to 2.40), p-value =0.035 for PWR]. Among sarcopenia parameters, PLT count was more likely to be associated with handgrip strength and muscle mass. After stratifying the participants by gender, sarcopenia parameters were no longer statistically significant in men.
CONCLUSION
This study showed that PLT and PWR were associated with sarcopenia after considering confounding factors, while this association was not seen in WBC. Moreover, results showed that gender had an important impact on sarcopenia parameters.
Identifiants
pubmed: 35395731
doi: 10.1186/s12877-022-02954-3
pii: 10.1186/s12877-022-02954-3
pmc: PMC8991783
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
300Informations de copyright
© 2022. The Author(s).
Références
Front Physiol. 2020 Jan 29;10:1607
pubmed: 32063863
Age Ageing. 2019 Jan 1;48(1):16-31
pubmed: 30312372
Biomed Res Int. 2015;2015:165078
pubmed: 26557653
Sci Rep. 2017 Nov 30;7(1):16609
pubmed: 29192175
Ageing Res Rev. 2019 Dec;56:100980
pubmed: 31726228
Clin Interv Aging. 2018 May 14;13:913-927
pubmed: 29785098
Clin Chim Acta. 2018 Feb;477:113-118
pubmed: 29217429
Maturitas. 2017 Feb;96:10-15
pubmed: 28041587
Eur J Epidemiol. 2019 Mar;34(3):211-219
pubmed: 30840181
BMC Fam Pract. 2001;2:5
pubmed: 11707152
J Frailty Aging. 2020;9(1):57-63
pubmed: 32150215
Exp Gerontol. 2018 Sep;110:223-229
pubmed: 29928932
Aging Clin Exp Res. 2017 Dec;29(6):1259
pubmed: 28364311
Connect Tissue Res. 2014 Aug;55(4):304-9
pubmed: 24874552
Clin Appl Thromb Hemost. 2015 Mar;21(2):139-43
pubmed: 24770327
Int J Environ Res Public Health. 2020 Feb 26;17(5):
pubmed: 32110901
Nutrients. 2018 Mar 16;10(3):
pubmed: 29547573
J Stroke Cerebrovasc Dis. 2016 Oct;25(10):2430-8
pubmed: 27372596
Hepatol Int. 2019 Nov;13(6):674-687
pubmed: 31705444
J Diabetes Metab Disord. 2014 Aug 21;13(1):88
pubmed: 25247153
FASEB J. 2006 Dec;20(14):2559-61
pubmed: 17077283
Sci Rep. 2021 Jan 11;11(1):450
pubmed: 33432036
J Frailty Aging. 2020;9(2):82-89
pubmed: 32259181
Front Public Health. 2020 May 20;8:180
pubmed: 32671006
Front Pharmacol. 2021 May 12;12:670155
pubmed: 34054542
BMJ Open. 2017 Aug 04;7(8):e013606
pubmed: 28780537
Maturitas. 2012 Feb;71(2):109-14
pubmed: 22153348
Ann Vasc Surg. 2021 Apr;72:72-78
pubmed: 32479878
Arch Gerontol Geriatr. 2021 Jan - Feb;92:104262
pubmed: 33032183
PLoS One. 2013;8(1):e54289
pubmed: 23382888
Cancer Manag Res. 2018 Oct 25;10:4935-4944
pubmed: 30464594
BMC Geriatr. 2019 Aug 27;19(1):233
pubmed: 31455238
Adv Physiol Educ. 2015 Dec;39(4):352-9
pubmed: 26628659
Maturitas. 2016 Sep;91:8-18
pubmed: 27451316
Am J Alzheimers Dis Other Demen. 2012 Sep;27(6):433-8
pubmed: 22930700
Blood. 2019 Aug 29;134(9):727-740
pubmed: 31311815
Dis Model Mech. 2009 May-Jun;2(5-6):231-7
pubmed: 19407331
Heart Fail Rev. 2020 Jan;25(1):21-30
pubmed: 31686283
Eur J Clin Nutr. 2021 Mar;75(3):456-463
pubmed: 32901103
Curr Opin Hematol. 2019 Sep;26(5):336-342
pubmed: 31348047
Heliyon. 2020 Oct 07;6(10):e05033
pubmed: 33083587
Maturitas. 2016 Feb;84:89-93
pubmed: 26675924
Ann Epidemiol. 2006 Feb;16(2):123-30
pubmed: 16246584
BMC Geriatr. 2021 Mar 9;21(1):172
pubmed: 33750321
J Diabetes Res. 2020 Oct 7;2020:3950404
pubmed: 33083494
Sci Rep. 2015 Sep 25;5:14453
pubmed: 26571361
J Clin Hypertens (Greenwich). 2005 Dec;7(12):705-11; quiz 712-3
pubmed: 16330892
BMC Geriatr. 2021 May 24;21(1):329
pubmed: 34030664
Arch Med Sci. 2017 Jun;13(4):851-863
pubmed: 28721154
Res Pract Thromb Haemost. 2019 Nov 26;4(1):36-45
pubmed: 31989083
J Ren Nutr. 2010 Sep;20(5 Suppl):S24-8
pubmed: 20797566
Aging Cell. 2012 Oct;11(5):867-75
pubmed: 22708967
J Bras Nefrol. 2015 Jan-Mar;37(1):98-105
pubmed: 25923756
J Am Med Dir Assoc. 2013 Aug;14(8):626.e9-13
pubmed: 23747142
BMC Geriatr. 2020 Nov 7;20(1):457
pubmed: 33160322
Thromb Res. 2019 Nov;183:36-44
pubmed: 31614293
Nat Rev Endocrinol. 2018 Oct;14(10):576-590
pubmed: 30046148
J Extracell Vesicles. 2017 May 16;6(1):1322454
pubmed: 28717419
J Am Med Dir Assoc. 2015 Nov 1;16(11):1003.e1-6
pubmed: 26385304
J Diabetes Metab Disord. 2020 May 29;19(2):727-734
pubmed: 33520799
J Public Health (Oxf). 2018 Jun 1;40(2):e99-e106
pubmed: 30020525
J Nutr Health Aging. 2020;24(1):83-90
pubmed: 31886813
J Bone Metab. 2018 Aug;25(3):187-193
pubmed: 30237999
Am J Med. 1990 Jun;88(6):601-6
pubmed: 2161185
Arch Gerontol Geriatr. 2018 Mar - Apr;75:20-27
pubmed: 29172062
Gen Thorac Cardiovasc Surg. 2018 Dec;66(12):716-722
pubmed: 30105630
J Gerontol A Biol Sci Med Sci. 2009 Nov;64(11):1183-9
pubmed: 19622801
Trends Endocrinol Metab. 2017 Mar;28(3):199-212
pubmed: 27789101
J Nutr. 1997 May;127(5 Suppl):990S-991S
pubmed: 9164280
Platelets. 2010;21(2):122-5
pubmed: 20050760
J Am Med Dir Assoc. 2018 May;19(5):378-383
pubmed: 29580886
BMJ Open. 2015 Dec 16;5(12):e009597
pubmed: 26674503