Dopamine receptor 1 expressing B cells exert a proinflammatory role in female patients with rheumatoid arthritis.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
08 04 2022
08 04 2022
Historique:
received:
07
10
2021
accepted:
30
03
2022
entrez:
9
4
2022
pubmed:
10
4
2022
medline:
13
4
2022
Statut:
epublish
Résumé
Rheumatoid arthritis (RA) is a chronic rheumatic disease with a clear sex-bias. Recent data indicated a role for dopamine in RA pathogenesis, while dopaminergic pathways can be modulated by estrogens. As defined mechanism of action of dopamine on B cell function in RA are unclear, we aimed to elucidate this, with special focus on sex-differences. Healthy controls (HC, n = 64) and RA patients (n = 61) were recruited. Expression of D
Identifiants
pubmed: 35396380
doi: 10.1038/s41598-022-09891-6
pii: 10.1038/s41598-022-09891-6
pmc: PMC8993840
doi:
Substances chimiques
Cytokines
0
DRD1 protein, human
0
Receptors, Dopamine
0
Receptors, Dopamine D1
0
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5985Informations de copyright
© 2022. The Author(s).
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