Overexpression of transcription factor FoxA2 in the developing skeleton causes an enlargement of the cartilage hypertrophic zone, but it does not trigger ectopic differentiation in immature chondrocytes.

Alkaline Phosphatase / metabolism Animals Bone and Bones / metabolism Cartilage / metabolism Cell Differentiation / genetics Chondrocytes / metabolism Core Binding Factor Alpha 1 Subunit / genetics Hepatocyte Nuclear Factor 3-beta / genetics Hypertrophy Matrix Metalloproteinase 13 / genetics Mice Transcription Factors / metabolism
Cartilage biology Chondrocyte hypertrophy Endochondral ossification FoxA2 Runx2

Journal

Bone
ISSN: 1873-2763
Titre abrégé: Bone
Pays: United States
ID NLM: 8504048

Informations de publication

Date de publication:
07 2022
Historique:
received: 21 12 2021
revised: 01 04 2022
accepted: 04 04 2022
pubmed: 11 4 2022
medline: 25 5 2022
entrez: 10 4 2022
Statut: ppublish

Résumé

We previously found that FoxA factors are necessary for chondrocyte differentiation. To investigate whether FoxA factors alone are sufficient to drive chondrocyte hypertrophy, we build a FoxA2 transgenic mouse in which FoxA2 cDNA is driven by a reiterated Tetracycline Response Element (TRE) and a minimal CMV promoter. This transgenic line was crossed with a col2CRE;Rosa26

Identifiants

DOI: 10.1016/j.bone.2022.116418 PMID: 35398294 PMC: PMC9133231
pubmed: 35398294
pii: S8756-3282(22)00094-1
doi: 10.1016/j.bone.2022.116418
pmc: PMC9133231
mid: NIHMS1808852
pii:
doi:

Substances chimiques

Core Binding Factor Alpha 1 Subunit 0
Foxa2 protein, mouse 0
Transcription Factors 0
Hepatocyte Nuclear Factor 3-beta 135845-92-0
Alkaline Phosphatase EC 3.1.3.1
Matrix Metalloproteinase 13 EC 3.4.24.-

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

116418

Subventions

Organisme : NIAMS NIH HHS
ID : R01 AR060735
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR069671
Pays : United States

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

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Auteurs

Nicole Bell (N)

Department of Developmental Biology, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA 02115, United States of America.

Sanket Bhagat (S)

Department of Developmental Biology, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA 02115, United States of America. Electronic address: SBhagat@ultragenyx.com.

Shanmugam Muruganandan (S)

Department of Developmental Biology, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA 02115, United States of America; Department of Biology, 134 Mugar Life Sciences Building, Northeastern University, 360 Huntington Ave, Boston, MA 02115, United States of America. Electronic address: m.shanmugam@northeastern.edu.

Ryunhyung Kim (R)

Department of Developmental Biology, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA 02115, United States of America. Electronic address: jekim982@gmail.com.

Kailing Ho (K)

Department of Developmental Biology, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA 02115, United States of America. Electronic address: kailing_ho@hsdm.harvard.edu.

Rachel Pierce (R)

Department of Biology, 134 Mugar Life Sciences Building, Northeastern University, 360 Huntington Ave, Boston, MA 02115, United States of America. Electronic address: ra.pierce@northeastern.edu.

Elena Kozhemyakina (E)

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, United States of America. Electronic address: elena.kozhemyakina@clarivate.com.

Andrew B Lassar (AB)

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, United States of America. Electronic address: andrew_lassar@hms.harvard.edu.

Laura Gamer (L)

Department of Developmental Biology, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA 02115, United States of America. Electronic address: laura_gamer@hsdm.harvard.edu.

Vicki Rosen (V)

Department of Developmental Biology, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA 02115, United States of America. Electronic address: vicki_rosen@hsdm.harvard.edu.

Andreia M Ionescu (AM)

Department of Developmental Biology, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA 02115, United States of America; Department of Biology, 134 Mugar Life Sciences Building, Northeastern University, 360 Huntington Ave, Boston, MA 02115, United States of America. Electronic address: a.ionescu@northeastern.edu.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Phosphoric monoester hydrolases › Phosphatase alcaline › Overexpression of transcription factor FoxA2...
questionsmedicales.fr › Eucaryotes › Animaux › Overexpression of transcription factor FoxA2...
questionsmedicales.fr › Tissus › Tissu conjonctif › Os et tissu osseux › Overexpression of transcription factor FoxA2...
questionsmedicales.fr › Tissus › Tissu conjonctif › Cartilage › Overexpression of transcription factor FoxA2...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Overexpression of transcription factor FoxA2...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Chondrocytes › Overexpression of transcription factor FoxA2...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription CBF › Sous-unités alpha du facteur CBF › Sous-unité alpha 1 du facteur CBF › Overexpression of transcription factor FoxA2...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif hélice ailée › Facteurs de transcription Forkhead › Facteur nucléaire hépatocytaire HNF-3 bêta › Overexpression of transcription factor FoxA2...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Hypertrophie › Overexpression of transcription factor FoxA2...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Secreted matrix metalloproteinases › Matrix Metalloproteinase 13 › Overexpression of transcription factor FoxA2...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Overexpression of transcription factor FoxA2...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Overexpression of transcription factor FoxA2...