The mouse nicotinamide mononucleotide adenylyltransferase chaperones diverse pathological amyloid client proteins.

Amyloidogenic Proteins / metabolism Animals Mice Molecular Chaperones / genetics Nicotinamide-Nucleotide Adenylyltransferase / genetics Protein Aggregation, Pathological / physiopathology
NMNAT Tau amyloid aggregation amyloid β chaperone islet amyloid polypeptide neurodegenerative diseases protein misfolding α-synuclein

Journal

The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R

Informations de publication

Date de publication:
05 2022
Historique:
received: 07 12 2021
revised: 31 03 2022
accepted: 01 04 2022
pubmed: 11 4 2022
medline: 7 6 2022
entrez: 10 4 2022
Statut: ppublish

Résumé

Molecular chaperones safeguard cellular protein homeostasis and obviate proteotoxicity. In the process of aging, as chaperone networks decline, aberrant protein amyloid aggregation accumulates in a mechanism that underpins neurodegeneration, leading to pathologies such as Alzheimer's disease and Parkinson's disease. Thus, it is important to identify and characterize chaperones for preventing such protein aggregation. In this work, we identified that the NAD

Identifiants

DOI: 10.1016/j.jbc.2022.101912 PMID: 35398355 PMC: PMC9108885
pubmed: 35398355
pii: S0021-9258(22)00352-0
doi: 10.1016/j.jbc.2022.101912
pmc: PMC9108885
pii:
doi:

Substances chimiques

Amyloidogenic Proteins 0
Molecular Chaperones 0
Nicotinamide-Nucleotide Adenylyltransferase EC 2.7.7.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

101912

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest The authors declare that they have no conflict of interests with the contents of this article.

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Auteurs

Chengan Huang (C)

Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China; Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Jinxia Lu (J)

Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China; Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Xiaojuan Ma (X)

Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China; University of the Chinese Academy of Sciences, Beijing, China.

Jiali Qiang (J)

Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China; University of the Chinese Academy of Sciences, Beijing, China.

Chuchu Wang (C)

Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China; University of the Chinese Academy of Sciences, Beijing, China.

Cong Liu (C)

Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.

Yanshan Fang (Y)

Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.

Yaoyang Zhang (Y)

Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.

Lin Jiang (L)

Department of Neurology, Molecular Biology Institute, and Brain Research Institute, UCLA, Los Angeles, California, USA.

Dan Li (D)

Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China; Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai, China. Electronic address: lidan2017@sjtu.edu.cn.

Shengnan Zhang (S)

Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China. Electronic address: zhangshengnan@sioc.ac.cn.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Amyloïde › Protéines amyloïdogènes › The mouse nicotinamide mononucleotide...
questionsmedicales.fr › Eucaryotes › Animaux › The mouse nicotinamide mononucleotide...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The mouse nicotinamide mononucleotide...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Chaperons moléculaires › The mouse nicotinamide mononucleotide...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Protéines liant le poly-adp-ribose › Nicotinamide nucleotide adenylyltransferase › The mouse nicotinamide mononucleotide...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Agrégation pathologique de protéines › The mouse nicotinamide mononucleotide...