Host transcriptomic signatures of tuberculosis can predict immune reconstitution inflammatory syndrome in HIV patients.

Adult BCG Vaccine Child HIV Infections / complications Humans Immune Reconstitution Inflammatory Syndrome / complications Transcriptome Tuberculosis / diagnosis
Bacille-Calmette-Guerin host biomarker immune reconstitution inflammatory syndrome transcriptomic signature tuberculosis

Journal

European journal of immunology
ISSN: 1521-4141
Titre abrégé: Eur J Immunol
Pays: Germany
ID NLM: 1273201

Informations de publication

Date de publication:
07 2022
Historique:
revised: 06 04 2022
received: 14 01 2022
accepted: 07 04 2022
pubmed: 11 4 2022
medline: 14 7 2022
entrez: 10 4 2022
Statut: ppublish

Résumé

Immune reconstitution inflammatory syndrome (IRIS) can be a complication of antiretroviral therapy (ART) in patients with advanced HIV, but its pathogenesis is uncertain. In tuberculosis (TB) endemic countries, IRIS is often associated with mycobacterial infections or Bacille-Calmette-Guerin (BCG) vaccination in children. With no predictive or confirmatory tests at present, IRIS remains a diagnosis of exclusion. We tested whether RISK6 and Sweeney3, validated immune-based blood transcriptomic signatures for TB, could predict or diagnose IRIS in HIV+ children and adults. Transcripts were measured by RT-qPCR in BCG-vaccinated children and by microarray in HIV+ adults with TB including TB meningitis (TBM). Signature scores before ART initiation and up to IRIS diagnosis were compared between participants who did or did not develop IRIS. In children, RISK6 and Sweeney3 discriminated IRIS cases from non-IRIS controls before ART, and at diagnosis. In adults with TB, RISK6 discriminated IRIS cases from controls after half-week on ART and at TB-IRIS onset. In adults with TBM, only Sweeney3 discriminated IRIS cases from controls before ART, while both signatures distinguished cases from controls at TB-IRIS onset. Parsimonious whole blood transcriptomic signatures for TB showed potential to predict and diagnose IRIS in HIV+ children and adults.

Identifiants

DOI: 10.1002/eji.202249815 PMID: 35398886 PMC: PMC9276552
pubmed: 35398886
doi: 10.1002/eji.202249815
pmc: PMC9276552
mid: NIHMS1796795
doi:

Substances chimiques

BCG Vaccine 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1112-1119

Subventions

Organisme : Wellcome Trust
ID : 098316
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 203135/Z/16/Z
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : UM1 AI068632
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI068616
Pays : United States
Organisme : Medical Research Council
ID : MR/R008922/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 214321/Z/18/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N013638/1
Pays : United Kingdom
Organisme : Cancer Research UK
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : UM1 AI106716
Pays : United States

Informations de copyright

© 2022 The Authors. European Journal of Immunology published by Wiley-VCH GmbH.

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Auteurs

Stanley Kimbung Mbandi (SK)

South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.

Hannah Painter (H)

Department of Infection Biology, London School of Hygiene & Tropical Medicine, London, UK.

Adam Penn-Nicholson (A)

South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.

Asma Toefy (A)

South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.

Mzwandile Erasmus (M)

South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.

Willem A Hanekom (WA)

South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.

Thomas J Scriba (TJ)

South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.

Rachel P J Lai (RPJ)

Department of Infectious Diseases, Imperial College London, London, UK.

Suzaan Marais (S)

Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory, South Africa.
Institute of Infectious Disease and Molecular Medicine and Department of Medicine, University of Cape Town, Observatory, South Africa.

Helen A Fletcher (HA)

Department of Infection Biology, London School of Hygiene & Tropical Medicine, London, UK.

Graeme Meintjes (G)

Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory, South Africa.
Institute of Infectious Disease and Molecular Medicine and Department of Medicine, University of Cape Town, Observatory, South Africa.

Robert J Wilkinson (RJ)

Department of Infectious Diseases, Imperial College London, London, UK.
Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Observatory, South Africa.
Institute of Infectious Disease and Molecular Medicine and Department of Medicine, University of Cape Town, Observatory, South Africa.
Francis Crick Institute, London, UK.

Mark F Cotton (MF)

Family Center for Research with Ubuntu, Department of Pediatrics & Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.

Savita Pahwa (S)

Department of Microbiology and Immunology, Miami Center for AIDS Research, University of Miami Miller School of Medicine, Miami, Florida, USA.

Mark J Cameron (MJ)

Department of Population & Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

Elisa Nemes (E)

South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
ORCID: 0000-0003-1662-4961

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Host transcriptomic signatures of tuberculosis...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Vaccins › Vaccins antibactériens › Vaccins antituberculeux › Vaccin BCG › Host transcriptomic signatures of tuberculosis...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Host transcriptomic signatures of tuberculosis...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › Host transcriptomic signatures of tuberculosis...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Host transcriptomic signatures of tuberculosis...
questionsmedicales.fr › Maladies du système immunitaire › Syndrome inflammatoire de restauration immunitaire › Host transcriptomic signatures of tuberculosis...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › Host transcriptomic signatures of tuberculosis...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram positif › Infections à Actinomycetales › Infections à Mycobacterium › Tuberculose › Host transcriptomic signatures of tuberculosis...