Alterations of thalamic nuclei volumes in patients with cluster headache.
Cluster headache
Network
Thalamic nuclei
Volume
Journal
Neuroradiology
ISSN: 1432-1920
Titre abrégé: Neuroradiology
Pays: Germany
ID NLM: 1302751
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
received:
24
02
2022
accepted:
05
04
2022
pubmed:
12
4
2022
medline:
13
8
2022
entrez:
11
4
2022
Statut:
ppublish
Résumé
This study aimed to compare the alterations of thalamic nuclei volumes and the intrinsic thalamic network in patients with cluster headache and healthy controls. We retrospectively enrolled 24 patients with episodic cluster headache and 24 healthy controls. We calculated the thalamic nuclei volumes in the patients with cluster headache and healthy controls based on three-dimensional T1-weighted imaging with automated segmentation using the FreeSurfer program. We also investigated the intrinsic thalamic network using structural co-variance analysis based on the thalamic nuclei volumes and graph theory under the BRAPH program. We compared the thalamic nuclei volumes and intrinsic thalamic networks in patients with cluster headaches and healthy controls. The right and left whole thalamic volumes did not differ in the patients with cluster headaches and healthy controls (0.4199 vs. 0.4069%, p = 0.2008; 0.4386 vs. 0.4273%, p = 0.3437; respectively). However, there were significant alterations of right and left medial geniculate nuclei volumes in the patients with cluster headaches and the healthy controls. The right and left medial geniculate nuclei volumes of the patients with cluster headaches were greater than those of the healthy controls (0.0088 vs. 0.0075%, p < 0.0001; 0.0086 vs. 0.0072%, p < 0.0001; respectively). The intrinsic thalamic networks of the groups were not different. This study demonstrates significant alterations in the bilateral medial geniculate nuclei volumes in patients with cluster headache compared to healthy controls. These alterations may be related to the pathophysiology of cluster headache. However, there are no changes in the intrinsic thalamic network in patients with cluster headache.
Identifiants
pubmed: 35399109
doi: 10.1007/s00234-022-02951-8
pii: 10.1007/s00234-022-02951-8
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1839-1846Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Références
May A, Schwedt TJ, Magis D, Pozo-Rosich P, Evers S, Wang S-J (2018) Cluster headache. Nat Rev Dis Prim 4(1):1–17
Chung PW, Kim BS, Park JW, Sohn JH, Lee MJ, Kim BK, Chu MK, Ahn JY, Choi YJ, Song TJ, Bae DW, Kim D, Kim JM, Kim SK, Park KY, Chung JM, Moon HS, Oh K, Chung CS, Cho SJ (2021) Smoking history and clinical features of cluster headache: results from the Korean Cluster Headache Registry. J Clin Neurol 17(2):229–235. https://doi.org/10.3988/jcn.2021.17.2.229
doi: 10.3988/jcn.2021.17.2.229
pubmed: 33835743
pmcid: 8053542
Arnold M (2018) Headache classification committee of the international headache society (IHS) the international classification of headache disorders. Cephalalgia 38(1):1–211
doi: 10.1177/0333102417738202
Hoffmann J, May A (2018) Diagnosis, pathophysiology, and management of cluster headache. The Lancet Neurol 17(1):75–83
doi: 10.1016/S1474-4422(17)30405-2
May A, Bahra A, Büchel C, Frackowiak RS, Goadsby PJ (1998) Hypothalamic activation in cluster headache attacks. The Lancet 352(9124):275–278
doi: 10.1016/S0140-6736(98)02470-2
Chou K-H, Yang F-C, Fuh J-L, Kuo C-Y, Wang Y-H, Lirng J-F, Lin Y-Y, Wang S-J, Lin C-P (2017) Bout-associated intrinsic functional network changes in cluster headache: a longitudinal resting-state functional MRI study. Cephalalgia 37(12):1152–1163
doi: 10.1177/0333102416668657
Pringsheim T (2002) Cluster headache: evidence for a disorder of circadian rhythm and hypothalamic function. Can J Neurol Sci 29(1):33–40
doi: 10.1017/S0317167100001694
Leone M, Bussone G (1993) A review of hormonal findings in cluster headache. Evidence for hypothalamic involvement Cephalalgia 13(5):309–317
doi: 10.1046/j.1468-2982.1993.1305309.x
Schulte LH, May A (2016) The migraine generator revisited: continuous scanning of the migraine cycle over 30 days and three spontaneous attacks. Brain 139(7):1987–1993
doi: 10.1093/brain/aww097
Lund N, Barloese M, Petersen A, Haddock B, Jensen R (2017) Chronobiology differs between men and women with cluster headache, clinical phenotype does not. Neurol 88(11):1069–1076
doi: 10.1212/WNL.0000000000003715
Yang F-C, Chou K-H, Kuo C-Y, Lin Y-Y, Lin C-P, Wang S-J (2018) The pathophysiology of episodic cluster headache: insights from recent neuroimaging research. Cephalalgia 38(5):970–983
doi: 10.1177/0333102417716932
Yang F-C, Chou K-H, Fuh J-L, Lee P-L, Lirng J-F, Lin Y-Y, Lin C-P, Wang S-J (2015) Altered hypothalamic functional connectivity in cluster headache: a longitudinal resting-state functional MRI study. J Neurol Neurosurg Psychiatry 86(4):437–445
doi: 10.1136/jnnp-2014-308122
Absinta M, Rocca MA, Colombo B, Falini A, Comi G, Filippi M (2012) Selective decreased grey matter volume of the pain-matrix network in cluster headache. Cephalalgia 32(2):109–115
doi: 10.1177/0333102411431334
Szabó N, Kincses ZT, Párdutz Á, Tóth E, Szok D, Csete G, Vécsei L (2013) White matter disintegration in cluster headache. J Headache Pain 14(1):1–6
doi: 10.1186/1129-2377-14-64
Qiu E, Wang Y, Ma L, Tian L, Liu R, Dong Z, Xu X, Zou Z, Yu S (2013) Abnormal brain functional connectivity of the hypothalamus in cluster headaches. PLoS One 8(2):e57896
doi: 10.1371/journal.pone.0057896
Teepker M, Menzler K, Belke M, Heverhagen JT, Voelker M, Mylius V, Oertel WH, Rosenow F, Knake S (2012) Diffusion tensor imaging in episodic cluster headache. Headache: The Journal of Head and Face Pain. 52(2):274–282
doi: 10.1111/j.1526-4610.2011.02000.x
Sprenger T, Ruether K, Boecker H, Valet M, Berthele A, Pfaffenrath V, Wöller A, Tölle T (2007) Altered metabolism in frontal brain circuits in cluster headache. Cephalalgia 27(9):1033–1042
doi: 10.1111/j.1468-2982.2007.01386.x
Ferraro S, Nigri A, Demichelis G, Pinardi C, Chiapparini L, Giani L, Proietti Cecchini A, Leone M (2020) Understanding cluster headache using magnetic resonance imaging. Front Neurol 11:535
doi: 10.3389/fneur.2020.00535
Kuner R, Kuner T (2021) Cellular circuits in the brain and their modulation in acute and chronic pain. Physiol Rev 101(1):213–258
doi: 10.1152/physrev.00040.2019
Apkarian AV, Bushnell MC, Treede R-D, Zubieta J-K (2005) Human brain mechanisms of pain perception and regulation in health and disease. Eur J Pain 9(4):463–484
doi: 10.1016/j.ejpain.2004.11.001
Ab Aziz CB, Ahmad AH (2006) The role of the thalamus in modulating pain. The Malaysian journal of medical sciences: MJMS 13(2):11
pubmed: 22589599
pmcid: 3349479
Shin KJ, Lee HJ, Park KM (2019) Alterations of individual thalamic nuclei volumes in patients with migraine. J Headache Pain 20(1):112. https://doi.org/10.1186/s10194-019-1063-3
doi: 10.1186/s10194-019-1063-3
pubmed: 31818256
pmcid: 6902536
Shin KJ, Lee H-J, Park KM (2019) Alterations of individual thalamic nuclei volumes in patients with migraine. J Headache Pain 20(1):1–8
doi: 10.1186/s10194-019-1063-3
Mijalkov M, Kakaei E, Pereira JB, Westman E, Volpe G, Alzheimer’s Disease Neuroimaging I (2017) BRAPH: a graph theory software for the analysis of brain connectivity. PLoS ONE 12(8):e0178798. https://doi.org/10.1371/journal.pone.0178798
doi: 10.1371/journal.pone.0178798
pubmed: 28763447
pmcid: 5538719
Farahani FV, Karwowski W, Lighthall NR (2019) Application of graph theory for identifying connectivity patterns in human brain networks: a systematic review. Front Neurosci 13:585. https://doi.org/10.3389/fnins.2019.00585
doi: 10.3389/fnins.2019.00585
pubmed: 31249501
pmcid: 6582769
Park KM, Lee BI, Shin KJ, Ha SY, Park J, Kim SE, Kim SE (2019) Pivotal role of subcortical structures as a network hub in focal epilepsy: evidence from graph theoretical analysis based on diffusion-tensor imaging. J Clin Neurol 15(1):68–76. https://doi.org/10.3988/jcn.2019.15.1.68
doi: 10.3988/jcn.2019.15.1.68
pubmed: 30618219
Holland PR, Goadsby PJ (2009) Cluster headache, hypothalamus, and orexin. Curr Pain Headache Rep 13(2):147–154
doi: 10.1007/s11916-009-0025-x
Rocca MA, Valsasina P, Absinta M, Colombo B, Barcella V, Falini A, Comi G, Filippi M (2010) Central nervous system dysregulation extends beyond the pain-matrix network in cluster headache. Cephalalgia 30(11):1383–1391
doi: 10.1177/0333102410365164
Yang F-C, Chou K-H, Fuh J-L, Huang C-C, Lirng J-F, Lin Y-Y, Lin C-P, Wang S-J (2013) Altered gray matter volume in the frontal pain modulation network in patients with cluster headache. PAIN® 154(6):801–807
doi: 10.1016/j.pain.2013.02.005
Kiraly A, Szabo N, Pardutz A, Toth E, Tajti J, Csete G, Farago P, Bodnar P, Szok D, Tuka B, Palinkas E, Ertsey C, Vecsei L, Kincses ZT (2018) Macro- and microstructural alterations of the subcortical structures in episodic cluster headache. Cephalalgia 38(4):662–673. https://doi.org/10.1177/0333102417703762
doi: 10.1177/0333102417703762
pubmed: 28425325
Sherman SM (2016) Thalamus plays a central role in ongoing cortical functioning. Nat Neurosci 19(4):533–541
doi: 10.1038/nn.4269
Sherman SM, Guillery R (2011) Distinct functions for direct and transthalamic corticocortical connections. J Neurophysiol 106(3):1068–1077
doi: 10.1152/jn.00429.2011
Moisset X, Bouhassira D (2007) Brain imaging of neuropathic pain. Neuroimage 37:S80–S88
doi: 10.1016/j.neuroimage.2007.03.054
Gustin SM, Peck CC, Wilcox SL, Nash PG, Murray GM, Henderson LA (2011) Different pain, different brain: thalamic anatomy in neuropathic and non-neuropathic chronic pain syndromes. J Neurosci 31(16):5956–5964
doi: 10.1523/JNEUROSCI.5980-10.2011
Sandrini G, Antonaci F, Lanfranchi S, Milanov I, Danilov A, Nappi G (2000) Asymmetrical reduction of the nociceptive flexion reflex threshold in cluster headache. Cephalalgia 20(7):647–652
doi: 10.1111/j.1468-2982.2000.00096.x
May A, Bahra A, Büchel C, Frackowiak R, Goadsby P (2000) PET and MRA findings in cluster headache and MRA in experimental pain. Neurology 55(9):1328–1335
doi: 10.1212/WNL.55.9.1328
Lee CC (2013) Thalamic and cortical pathways supporting auditory processing. Brain Lang 126(1):22–28
doi: 10.1016/j.bandl.2012.05.004
Weinberger NM (2011) The medial geniculate, not the amygdala, as the root of auditory fear conditioning. Hear Res 274(1–2):61–74
doi: 10.1016/j.heares.2010.03.093
Aizenberg M, Rolón-Martínez S, Pham T, Rao W, Haas JS, Geffen MN (2019) Projection from the amygdala to the thalamic reticular nucleus amplifies cortical sound responses. Cell reports 28(3):605-615. e604
doi: 10.1016/j.celrep.2019.06.050
Donishi T, Kimura A, Imbe H, Yokoi I, Kaneoke Y (2011) Sub-threshold cross-modal sensory interaction in the thalamus: lemniscal auditory response in the medial geniculate nucleus is modulated by somatosensory stimulation. Neuroscience 174:200–215. https://doi.org/10.1016/j.neuroscience.2010.11.041
doi: 10.1016/j.neuroscience.2010.11.041
pubmed: 21111788
Farahani FV, Karwowski W, Lighthall NR (2019) Application of graph theory for identifying connectivity patterns in human brain networks: a systematic review. Frontiers in Neuroscience 13:585
doi: 10.3389/fnins.2019.00585
Ha SY, Park KM (2019) Alterations of structural connectivity in episodic cluster headache: a graph theoretical analysis. J Clin Neurosci 62:60–65. https://doi.org/10.1016/j.jocn.2019.01.007
doi: 10.1016/j.jocn.2019.01.007
pubmed: 30655236