The oncogenic landscape of the idiopathic pulmonary fibrosis: a narrative review.
Idiopathic pulmonary fibrosis (IPF)
cancer
genetics
immunotherapy
personalized medicine
Journal
Translational lung cancer research
ISSN: 2218-6751
Titre abrégé: Transl Lung Cancer Res
Pays: China
ID NLM: 101646875
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
06
11
2021
accepted:
16
02
2022
entrez:
11
4
2022
pubmed:
12
4
2022
medline:
12
4
2022
Statut:
ppublish
Résumé
Translational research is a source of continuous innovation in medicine, more particularly for clinical research on new treatment modalities in idiopathic pulmonary fibrosis (IPF) patients. However, the heterogeneity of the disease is well recognized, and different pathological and molecular settings have been identified. The molecular mechanisms by which IPF proceeds in time and space remains poorly understood. Although some IPF features are reminiscent of cancer, the dynamics of malignant divergent clonal selective pressure and heterogeneity clearly differ from those occurring in IPF. This is reflected in the absence of patient proper selection and stratification to biological agents (pirfenidone, nintedanib) which limit therapeutic efficacy. Consequently, increased costs are related to the clinical management of advanced IPF patients. Steady collaboration and fluid communication between pneumo-oncologists, radiologists and molecular biologists is a clear priority for the correct interpretation of tests and the definition of effective personalized strategies against this orphan disease. The present work aims at providing the most relevant hints shared by cancer and IPF. A systematic literature review was performed to identify all relevant data. The examined databases were Scopus, Web of Science, Cochrane, Google Scholar, and PubMed. The last search was run on January 5, 2022. We have primarily conducted separated research for lung cancer, IPF, genetics, epigenetics, surgery in IPF and cancer. The data here presented mainly focus on gene mutations, epigenetics and novel therapeutic approaches. Moreover, epidemiology, prognostic variables and in new treatment strategies adopted in patients with IPF and lung cancer are discussed as well. Overall, the findings of this narrative review will be of help in defining the key molecular features that could applied in IPF setting with promising rationale to improve therapy and to better manage those cases carrying IPF and cancer concomitantly.
Sections du résumé
Background and Objective
UNASSIGNED
Translational research is a source of continuous innovation in medicine, more particularly for clinical research on new treatment modalities in idiopathic pulmonary fibrosis (IPF) patients. However, the heterogeneity of the disease is well recognized, and different pathological and molecular settings have been identified. The molecular mechanisms by which IPF proceeds in time and space remains poorly understood. Although some IPF features are reminiscent of cancer, the dynamics of malignant divergent clonal selective pressure and heterogeneity clearly differ from those occurring in IPF. This is reflected in the absence of patient proper selection and stratification to biological agents (pirfenidone, nintedanib) which limit therapeutic efficacy. Consequently, increased costs are related to the clinical management of advanced IPF patients. Steady collaboration and fluid communication between pneumo-oncologists, radiologists and molecular biologists is a clear priority for the correct interpretation of tests and the definition of effective personalized strategies against this orphan disease. The present work aims at providing the most relevant hints shared by cancer and IPF.
Methods
UNASSIGNED
A systematic literature review was performed to identify all relevant data. The examined databases were Scopus, Web of Science, Cochrane, Google Scholar, and PubMed. The last search was run on January 5, 2022. We have primarily conducted separated research for lung cancer, IPF, genetics, epigenetics, surgery in IPF and cancer.
Key Content and Findings
UNASSIGNED
The data here presented mainly focus on gene mutations, epigenetics and novel therapeutic approaches. Moreover, epidemiology, prognostic variables and in new treatment strategies adopted in patients with IPF and lung cancer are discussed as well.
Conclusions
UNASSIGNED
Overall, the findings of this narrative review will be of help in defining the key molecular features that could applied in IPF setting with promising rationale to improve therapy and to better manage those cases carrying IPF and cancer concomitantly.
Identifiants
pubmed: 35399571
doi: 10.21037/tlcr-21-880
pii: tlcr-11-03-472
pmc: PMC8988078
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
472-496Informations de copyright
2022 Translational Lung Cancer Research. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tlcr.amegroups.com/article/view/10.21037/tlcr-21-880/coif). The authors have no conflicts of interest to declare.
Références
Int J Mol Sci. 2019 Mar 22;20(6):
pubmed: 30909462
Respirology. 2009 Jul;14(5):723-8
pubmed: 19659650
J Thorac Cardiovasc Surg. 2014 May;147(5):1604-1611.e3
pubmed: 24267779
Hum Mol Genet. 2016 Apr 15;25(8):1457-67
pubmed: 26792177
Am J Respir Crit Care Med. 2013 Dec 15;188(12):1442-50
pubmed: 24070541
Diagnostics (Basel). 2021 Jul 02;11(7):
pubmed: 34359285
Minerva Med. 2015 Aug;106(4 Suppl 3):17-24
pubmed: 27427121
Thorax. 2009 Aug;64(8):692-7
pubmed: 19359270
Front Oncol. 2019 Sep 06;9:877
pubmed: 31555602
Stem Cell Res Ther. 2021 Feb 25;12(1):147
pubmed: 33632305
JCI Insight. 2019 Mar 21;4(6):
pubmed: 30763282
NPJ Precis Oncol. 2020 Dec 10;4(1):33
pubmed: 33303906
Lung. 2013 Apr;191(2):199-205
pubmed: 23344525
Am J Respir Crit Care Med. 2003 Aug 15;168(4):431-5
pubmed: 12746254
Mol Med Rep. 2017 Dec;16(6):8085-8091
pubmed: 28944926
Am J Physiol Cell Physiol. 2014 Aug 1;307(3):C234-44
pubmed: 24898581
Annu Rev Cell Dev Biol. 2001;17:463-516
pubmed: 11687497
Clin Transl Med. 2019 Aug 28;8(1):24
pubmed: 31468250
Mayo Clin Proc. 2002 Aug;77(8):763-70
pubmed: 12173712
Diabetes Technol Ther. 2002;4(2):163-74
pubmed: 12079620
Sci Rep. 2021 Jun 17;11(1):12732
pubmed: 34140559
Eur Respir J. 2018 Dec 13;52(6):
pubmed: 30545962
Respir Res. 2006 Oct 20;7:130
pubmed: 17054776
J Int Med Res. 2021 Sep;49(9):3000605211016998
pubmed: 34521243
Am J Physiol Lung Cell Mol Physiol. 2008 May;294(5):L891-901
pubmed: 18162602
J Clin Invest. 2004 Jan;113(2):243-52
pubmed: 14722616
Sarcoidosis Vasc Diffuse Lung Dis. 2015 Jan 05;31(4):266-74
pubmed: 25591137
Am J Respir Cell Mol Biol. 2017 Jul;57(1):77-90
pubmed: 28257580
Pulm Med. 2012;2012:315918
pubmed: 22900168
Cell Transplant. 2018 Oct;27(10):1495-1503
pubmed: 30187775
Pulm Pharmacol Ther. 2017 Aug;45:1-10
pubmed: 28377145
Cancer Res. 2007 Jul 1;67(13):6007-11
pubmed: 17616654
Am J Physiol Lung Cell Mol Physiol. 2020 Apr 1;318(4):L705-L722
pubmed: 32083945
J Exp Med. 2010 Aug 2;207(8):1589-97
pubmed: 20643828
Mod Pathol. 2012 Mar;25(3):416-33
pubmed: 22037258
Am J Respir Crit Care Med. 2019 May 1;199(9):1127-1138
pubmed: 30789747
Proc Am Thorac Soc. 2011 May;8(2):158-62
pubmed: 21543794
Eur Respir J. 2021 Jul 22;58(1):
pubmed: 33766945
Thorax. 2010 Jun;65(6):553-4
pubmed: 20522857
Nat Rev Drug Discov. 2019 Feb;18(2):99-115
pubmed: 30470818
Sci Rep. 2020 Jul 2;10(1):10900
pubmed: 32616870
Lancet Respir Med. 2017 Jun;5(6):472-473
pubmed: 28664848
Respir Med. 2007 Dec;101(12):2534-40
pubmed: 17870458
Genes Dis. 2017 Oct 25;4(4):204-214
pubmed: 30258924
J Clin Invest. 2014 Feb;124(2):564-79
pubmed: 24382352
Int Immunopharmacol. 2017 Nov;52:272-280
pubmed: 28961490
Eur Respir J. 2019 Feb 14;53(2):
pubmed: 30442715
ERJ Open Res. 2017 Jul 12;3(3):
pubmed: 28717640
Sarcoidosis Vasc Diffuse Lung Dis. 2014 Oct 20;31(3):191-7
pubmed: 25363218
Thorax. 2013 Feb;68(2):155-62
pubmed: 23143842
Cell. 2010 Apr 2;141(1):52-67
pubmed: 20371345
Respir Investig. 2018 Jan;56(1):72-79
pubmed: 29325685
Nat Commun. 2020 Jul 30;11(1):3801
pubmed: 32732879
Br J Cancer. 2004 Aug;91 Suppl 2:S3-10
pubmed: 15340372
Biochim Biophys Acta. 2016 Apr;1863(4):520-32
pubmed: 26792405
Int J Mol Sci. 2021 Jun 11;22(12):
pubmed: 34208111
Cell Rep Med. 2020 Jul 21;1(4):100056
pubmed: 33205063
Front Oncol. 2021 Jun 18;11:673877
pubmed: 34221992
Cancer Cell. 2013 Jun 10;23(6):718-23
pubmed: 23763999
Biochim Biophys Acta. 2012 Jul;1820(7):949-56
pubmed: 22507268
Cardiovasc Res. 2009 Apr 1;82(1):21-9
pubmed: 19147652
Int J Med Sci. 2018 Sep 7;15(13):1443-1448
pubmed: 30443163
J Clin Imaging Sci. 2014 Mar 21;4:17
pubmed: 24744974
Respir Med. 2019 Feb;147:79-91
pubmed: 30704705
Am J Respir Crit Care Med. 2013 Jul 15;188(2):133-40
pubmed: 23306542
Biomed Pharmacother. 2018 Apr;100:335-348
pubmed: 29453043
Cancer Sci. 2020 Jul;111(7):2482-2487
pubmed: 32426915
Transl Res. 2011 Apr;157(4):191-9
pubmed: 21420029
Int J Cancer. 2021 Jun 15;148(12):3008-3018
pubmed: 33533494
Nat Commun. 2020 Feb 28;11(1):1064
pubmed: 32111836
Front Oncol. 2019 Mar 05;9:129
pubmed: 30891428
Curr Drug Targets. 2021;22(7):793-802
pubmed: 32988351
Cell Mol Life Sci. 2018 Oct;75(19):3539-3551
pubmed: 30030592
Bioorg Med Chem. 2007 Mar 15;15(6):2223-68
pubmed: 17275314
Respir Res. 2017 Feb 1;18(1):29
pubmed: 28143484
Eur Respir J. 2017 Aug 10;50(2):
pubmed: 28798088
Front Pharmacol. 2021 Jul 05;12:692551
pubmed: 34290610
J Clin Invest. 2018 Jun 1;128(6):2389-2405
pubmed: 29733296
J Clin Med. 2019 Sep 26;8(10):
pubmed: 31561518
JCI Insight. 2020 Jul 23;5(14):
pubmed: 32544088
J Transl Med. 2016 Sep 02;14:256
pubmed: 27590450
Int J Radiat Oncol Biol Phys. 2016 Aug 1;95(5):1378-1390
pubmed: 27479723
Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8242-7
pubmed: 27364009
In Vitro Cell Dev Biol Anim. 2008 Jan-Feb;44(1-2):17-25
pubmed: 18071837
Cell Transplant. 2018 Nov;27(11):1581-1587
pubmed: 29991279
Toxicol Ind Health. 2010 Feb;26(1):47-53
pubmed: 20056742
Sci Rep. 2019 Aug 29;9(1):12561
pubmed: 31467375
Surg Today. 2020 Aug;50(8):905-911
pubmed: 32144483
Nat Rev Genet. 2003 Jul;4(7):544-58
pubmed: 12838346
J Thorac Cardiovasc Surg. 2015 Jan;149(1):64-9, 70.e1-2
pubmed: 25439777
Am J Physiol Lung Cell Mol Physiol. 2020 Oct 1;319(4):L675-L682
pubmed: 32877221
Gut. 2016 Nov;65(11):1895-1905
pubmed: 27624887
BMC Pulm Med. 2019 Aug 22;19(1):156
pubmed: 31438923
Chest. 2017 May;151(5):971-981
pubmed: 27890713
Biochim Biophys Acta. 1996 Jul 26;1302(2):93-109
pubmed: 8695669
Matrix Biol. 2018 Aug;68-69:422-434
pubmed: 29567123
Thorax. 2022 May;77(5):470-476
pubmed: 34593614
Nat Rev Mol Cell Biol. 2010 Dec;11(12):834-48
pubmed: 21102609
Am J Physiol Lung Cell Mol Physiol. 2021 Aug 1;321(2):L440-L450
pubmed: 34160296
Am J Respir Crit Care Med. 2021 Oct 15;204(8):954-966
pubmed: 34280322
Stem Cells Transl Med. 2016 Oct;5(10):1307-1318
pubmed: 27388243
Front Pharmacol. 2020 Dec 11;11:607689
pubmed: 33384604
Biochem Biophys Res Commun. 2007 Feb 2;353(1):104-8
pubmed: 17174272
Cancers (Basel). 2019 Jul 19;11(7):
pubmed: 31330946
J Clin Oncol. 2006 Apr 10;24(11):1679-88
pubmed: 16549822
PLoS One. 2019 Apr 18;14(4):e0215565
pubmed: 30998768
Respir Res. 2011 Jun 08;12:73
pubmed: 21649933
PLoS One. 2012;7(4):e33770
pubmed: 22506007
Lung Cancer. 2021 Jan;151:76-83
pubmed: 33246647
J Pathol. 2013 Jan;229(2):264-73
pubmed: 23097091
Stem Cell Res Ther. 2018 Sep 26;9(1):257
pubmed: 30257725
Eur Radiol. 2016 Feb;26(2):556-66
pubmed: 26003791
J Pathol. 2018 Jan;244(1):25-35
pubmed: 28862766
Exp Mol Med. 2019 Mar 20;51(3):1-11
pubmed: 30902967
Open Med (Wars). 2021 Mar 26;16(1):481-490
pubmed: 33817326
Oncogene. 2008 Jun 5;27(25):3635-40
pubmed: 18212743
Am J Physiol Cell Physiol. 2014 Aug 1;307(3):C232-3
pubmed: 24898582
Expert Opin Biol Ther. 2016;16(3):375-87
pubmed: 26593230
Pathol Int. 1995 Dec;45(12):925-32
pubmed: 8808297
Clin Sci (Lond). 2009 Jan;116(1):27-35
pubmed: 19037882
Front Cell Dev Biol. 2020 Oct 09;8:582370
pubmed: 33163495
Curr Opin Pulm Med. 2015 Sep;21(5):454-62
pubmed: 26176965
Am J Respir Crit Care Med. 2021 Jul 1;204(1):9-11
pubmed: 33626294
Nat Commun. 2013;4:2563
pubmed: 24113622
J Thorac Dis. 2018 Dec;10(12):6660-6669
pubmed: 30746211
Nat Genet. 2012 Oct;44(10):1104-10
pubmed: 22941188
Am J Respir Crit Care Med. 2000 Jan;161(1):1-2
pubmed: 10619788
J Cell Mol Med. 2020 Dec;24(23):13913-13926
pubmed: 33179861
Mucosal Immunol. 2019 Jan;12(1):212-222
pubmed: 30315241
Front Oncol. 2021 Jun 18;11:619949
pubmed: 34221956
Mol Aspects Med. 2017 Apr;54:89-102
pubmed: 27720780
J Thorac Oncol. 2017 Jul;12(7):e96-e97
pubmed: 28629548
CA Cancer J Clin. 2005 Jan-Feb;55(1):45-54; quiz 57
pubmed: 15661686
Surg Today. 2015 Oct;45(10):1263-70
pubmed: 25412984
Radiat Oncol. 2019 Jan 28;14(1):19
pubmed: 30691496
J Thorac Dis. 2019 Oct;11(Suppl 17):S2155-S2172
pubmed: 31737343
Chest. 2019 Aug;156(2):383-391
pubmed: 31125557
ERJ Open Res. 2019 Dec 16;5(4):
pubmed: 31857992
Am J Hum Genet. 2009 Jan;84(1):52-9
pubmed: 19100526
Am J Respir Crit Care Med. 2021 Oct 15;204(8):881-883
pubmed: 34478358
Transl Oncol. 2014 Oct;7(5):650-5
pubmed: 24935008
Biochem Biophys Res Commun. 2016 Oct 28;479(4):676-682
pubmed: 27693697
Annu Rev Med. 2002;53:409-35
pubmed: 11818483
Lancet Respir Med. 2018 Feb;6(2):86-88
pubmed: 29241977
Mol Cancer. 2020 Sep 24;19(1):145
pubmed: 32972405
Expert Rev Clin Immunol. 2014 May;10(5):593-619
pubmed: 24678812
Mol Med Rep. 2018 May;17(5):7105-7112
pubmed: 29568927
Chest. 2002 Apr;121(4):1278-89
pubmed: 11948064
Int J Mol Sci. 2020 Apr 26;21(9):
pubmed: 32357415
Hum Genet. 2003 Nov;113(6):542-50
pubmed: 13680361
Mol Cell Probes. 2020 Aug;52:101566
pubmed: 32234341
J Clin Invest. 2015 Nov 2;125(11):4021-5
pubmed: 26413870
Cancer Gene Ther. 2021 Aug;28(7-8):864-874
pubmed: 32759987
NPJ Precis Oncol. 2020 Mar 25;4:7
pubmed: 32219176
Dis Model Mech. 2013 Jan;6(1):9-17
pubmed: 23268535
Clin Lung Cancer. 2021 Sep;22(5):e738-e744
pubmed: 33663958
Nihon Kyobu Shikkan Gakkai Zasshi. 1991 May;29(5):560-5
pubmed: 1653375
Oncotarget. 2017 May 23;8(60):102600-102616
pubmed: 29254275
Curr Opin Rheumatol. 2013 Jan;25(1):101-7
pubmed: 23114590
Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16663-8
pubmed: 17925434
Thorac Cancer. 2020 Jun;11(6):1720-1723
pubmed: 32285615
Cancer Res. 2017 Apr 1;77(7):1730-1740
pubmed: 28108514
Thorac Cancer. 2020 Nov;11(11):3317-3325
pubmed: 32986306
PLoS One. 2012;7(1):e30442
pubmed: 22291954
J Pediatr. 2013 Dec;163(6):1778-80
pubmed: 23932215
Front Immunol. 2021 Jun 14;12:629854
pubmed: 34194423
Front Pharmacol. 2020 Dec 04;11:590972
pubmed: 33343360
J Clin Invest. 2018 Aug 31;128(9):3745-3746
pubmed: 30102252
Lancet. 2011 May 21;377(9779):1727-9
pubmed: 21571363
J Androl. 2011 Mar-Apr;32(2):170-82
pubmed: 20864652
Tohoku J Exp Med. 1992 Jul;167(3):231-7
pubmed: 1488744
Am J Respir Crit Care Med. 2011 Mar 15;183(6):788-824
pubmed: 21471066
Surg Today. 2020 May;50(5):469-474
pubmed: 31773277
Am J Respir Cell Mol Biol. 2015 Feb;52(2):217-31
pubmed: 25029475
Nat Rev Immunol. 2020 Nov;20(11):651-668
pubmed: 32433532
Curr Opin Cell Biol. 2014 Dec;31:98-105
pubmed: 25305631
Onco Targets Ther. 2018 Oct 31;11:7643-7653
pubmed: 30464513
Adv Drug Deliv Rev. 2018 Apr;129:78-94
pubmed: 29269274
Semin Cancer Biol. 2020 Feb;60:72-95
pubmed: 31412294
Cells. 2021 Oct 15;10(10):
pubmed: 34685744
Mol Pharmacol. 2013 Jan;83(1):283-93
pubmed: 23115324
Sci Transl Med. 2018 Sep 26;10(460):
pubmed: 30257954
NPJ Regen Med. 2019 Dec 2;4:22
pubmed: 31815001
Front Cell Dev Biol. 2021 Mar 09;9:639657
pubmed: 33768094
Am J Respir Crit Care Med. 2009 Apr 1;179(7):588-94
pubmed: 19151190
J Clin Invest. 2012 Dec;122(12):4388-400
pubmed: 23143308
Am J Respir Crit Care Med. 2002 May 1;165(9):1322-8
pubmed: 11991887
BMC Med. 2015 Nov 09;13:277
pubmed: 26552487
Nihon Kyobu Shikkan Gakkai Zasshi. 1994 Dec;32 Suppl:187-92
pubmed: 7602830
Gen Thorac Cardiovasc Surg. 2015 Mar;63(3):164-72
pubmed: 25352311
Front Immunol. 2021 Apr 22;12:663203
pubmed: 33995390
Lancet Oncol. 2014 Feb;15(2):143-55
pubmed: 24411639
J Clin Invest. 1999 Mar;103(6):779-88
pubmed: 10079098
J Immunol. 2004 Apr 1;172(7):4068-76
pubmed: 15034018
Pathol Int. 1999 Dec;49(12):1060-6
pubmed: 10632926
Transl Res. 2015 Jan;165(1):48-60
pubmed: 24746870
J Clin Invest. 2021 Jan 19;131(2):
pubmed: 33463535
Am J Respir Crit Care Med. 2019 May 1;199(9):1054-1056
pubmed: 30807204
Am J Respir Crit Care Med. 2013 Feb 15;187(4):397-405
pubmed: 23306545
Thorac Cancer. 2018 Nov;9(11):1519-1521
pubmed: 30152594
Stem Cells Transl Med. 2021 Jul;10(7):1021-1032
pubmed: 33624948
Int J Mol Sci. 2020 Aug 06;21(16):
pubmed: 32781778
Int J Mol Sci. 2021 Mar 12;22(6):
pubmed: 33809111
Am J Respir Cell Mol Biol. 2020 Jun;62(6):681-691
pubmed: 31991090
Respir Res. 2009 May 13;10:36
pubmed: 19439069
Int J Mol Sci. 2020 Jun 15;21(12):
pubmed: 32549377
PLoS One. 2013 Apr 16;8(4):e61754
pubmed: 23613925
N Engl J Med. 2012 May 24;366(21):1968-77
pubmed: 22607134
Lancet Respir Med. 2014 Jul;2(7):548-56
pubmed: 24767767
BMC Cancer. 2020 Oct 12;20(1):986
pubmed: 33046043
Lung Cancer. 2017 Apr;106:8-16
pubmed: 28285699
Am J Respir Crit Care Med. 2014 Oct 15;190(8):867-78
pubmed: 25090037
Respirology. 2020 Aug;25(8):850-854
pubmed: 31694070
Nat Rev Clin Oncol. 2017 Sep;14(9):531-548
pubmed: 28252003
Cancer Epidemiol Biomarkers Prev. 2008 May;17(5):1127-35
pubmed: 18483334
Pharmacol Res. 2021 Nov;173:105910
pubmed: 34562602
Am J Respir Crit Care Med. 2018 Jan 1;197(1):94-103
pubmed: 28787186
Future Med Chem. 2021 Nov;13(21):1885-1906
pubmed: 34590501
Respir Res. 2016 Jul 22;17(1):90
pubmed: 27450274
Biomed Pharmacother. 2018 Oct;106:1727-1733
pubmed: 30119248
Radiother Oncol. 2021 Feb;155:269-277
pubmed: 33245945
Respiration. 2011;81(5):353-8
pubmed: 21502777
Eur Respir J. 2010 Mar;35(3):496-504
pubmed: 20190329
Minerva Med. 2016 Feb;107(1 Suppl 1):9-14
pubmed: 27427394
Clin Sci (Lond). 2016 Apr;130(8):575-86
pubmed: 26744410
Eur Respir J. 2015 May;45(5):1434-45
pubmed: 25745043
Am J Surg Pathol. 2005 May;29(5):633-9
pubmed: 15832087
PLoS One. 2011 Feb 23;6(2):e14715
pubmed: 21373184
Oncotarget. 2021 Aug 31;12(18):1802-1810
pubmed: 34504652
PLoS One. 2021 Apr 7;16(4):e0249687
pubmed: 33826640
J Cell Physiol. 2018 Mar;233(3):2451-2463
pubmed: 28776666
Radiother Oncol. 2017 Jul;124(1):1-10
pubmed: 28666551
Chest. 2015 Jan;147(1):157-164
pubmed: 25166895
Curr Opin Pulm Med. 2015 Nov;21(6):626-33
pubmed: 26390339
Nat Rev Drug Discov. 2008 Jun;7(6):504-16
pubmed: 18511928
N Engl J Med. 2001 Feb 22;344(8):573-9
pubmed: 11207353
BMC Pulm Med. 2019 Aug 14;19(1):149
pubmed: 31412851
Eur Respir J. 2001 Jun;17(6):1216-9
pubmed: 11491167
Sci Rep. 2021 Apr 15;11(1):8312
pubmed: 33859288
Nature. 2014 Jan 16;505(7483):412-6
pubmed: 24317696
PLoS One. 2010 May 19;5(5):e10680
pubmed: 20502709
Med Hypotheses. 2020 Nov;144:110005
pubmed: 32575019
Mol Cancer Ther. 2017 Nov;16(11):2598-2608
pubmed: 28835386
Nature. 2013 May 2;497(7447):67-73
pubmed: 23636398
Thorac Cancer. 2021 May;12(9):1457-1460
pubmed: 33742758
Thorax. 2018 May;73(5):481-484
pubmed: 28802277
Br J Cancer. 2021 Mar;124(5):914-924
pubmed: 33299131
J Proteome Res. 2014 Feb 7;13(2):982-96
pubmed: 24283195
Eur Respir Rev. 2018 Dec 21;27(150):
pubmed: 30578336
Thorax. 2022 Feb;77(2):186-190
pubmed: 34521729
Cell Signal. 2020 Feb;66:109482
pubmed: 31760172
Cell Cycle. 2012 Jan 1;11(1):177-86
pubmed: 22185756
Immunogenetics. 2012 May;64(5):371-7
pubmed: 22322675
Respirol Case Rep. 2018 Sep 14;6(8):e00363
pubmed: 30237884
Int J Mol Sci. 2021 Mar 24;22(7):
pubmed: 33805152
Cancer Lett. 2003 May 8;194(1):1-11
pubmed: 12706853
PLoS One. 2014 Apr 17;9(4):e95479
pubmed: 24743427
Sci Rep. 2016 Jul 20;6:29952
pubmed: 27435875
J Thorac Oncol. 2020 Mar;15(3):e34-e35
pubmed: 32093856
Int J Mol Sci. 2019 Jan 30;20(3):
pubmed: 30704051
Korean J Radiol. 2020 Feb;21(2):159-171
pubmed: 31997591
J Biol Chem. 2014 Apr 11;289(15):10668-10679
pubmed: 24591516
Eur Respir J. 2021 Feb 4;57(2):
pubmed: 33008934
Cancer Gene Ther. 2021 Sep;28(9):984-999
pubmed: 33712707
Am J Respir Crit Care Med. 2000 Aug;162(2 Pt 1):755-8
pubmed: 10934117
Medicine (Baltimore). 2016 Dec;95(50):e5716
pubmed: 27977621
Noncoding RNA. 2019 Apr 19;5(2):
pubmed: 31010202
J Immunol Res. 2019 Jul 29;2019:1394191
pubmed: 31485458