PML nuclear body biogenesis and oligomerization-driven leukemogenesis.
Leukemogenesis
Oligomerization
PML nuclear body
PML/RARα
Journal
Blood science (Baltimore, Md.)
ISSN: 2543-6368
Titre abrégé: Blood Sci
Pays: United States
ID NLM: 9918248414306676
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
24
09
2019
accepted:
02
10
2019
entrez:
11
4
2022
pubmed:
16
1
2020
medline:
16
1
2020
Statut:
epublish
Résumé
PML nuclear bodies (NBs), which are increasingly recognized as the central hub of many cellular signaling events, are superassembled spherical complexes with diameters of 0.1-2 μm. Recent studies reveal that RING tetramerization and B1-box polymerization are key factors to the overall PML NBs assembly. The productive RBCC oligomerization allows subsequent PML biogenesis steps, including the PML auto-sumoylation and partners recruitment via SUMO-SIM interactions. In promyelocytic leukemia, the oncoprotein PML/RARα (P/R) inhibits PML NBs assembly and leads to a full-fledged leukemogenesis. In this review, we review the recent progress in PML and acute promyelocytic leukemia fields, highlighting the protein oligomerization as an important direction of future targeted therapy.
Identifiants
pubmed: 35399865
doi: 10.1097/BS9.0000000000000034
pii: BLS-19-039
pmc: PMC8975047
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
7-10Informations de copyright
Copyright © 2020 The Authors. Published by Wolters Kluwer Health Inc., on behalf of the Chinese Association for Blood Sciences.
Déclaration de conflit d'intérêts
Conflicts of interest: The authors declare that they have no conflicts of interest related to the subject matter or materials discussed in this article.
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