Risk-reduction strategies for late complications arising from brain metastases treated with radiotherapy: a narrative review.
Radiotherapy (RT)
brain metastases (BM)
complications
stereotactic radiosurgery
whole-brain radiotherapy
Journal
Chinese clinical oncology
ISSN: 2304-3873
Titre abrégé: Chin Clin Oncol
Pays: China
ID NLM: 101608375
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
received:
10
09
2021
accepted:
14
12
2021
pubmed:
12
4
2022
medline:
12
5
2022
entrez:
11
4
2022
Statut:
ppublish
Résumé
This review will focus on the late neurological complications from cranial irradiation and relevant mitigation strategies. Radiotherapy (RT) remains an important pillar in the management of brain metastases. Patients being treated in the modern era do experience longer survival, because of superior intra- and extra-cranial disease control. As a result, they can be more prone to developing and manifesting late complications post-brain radiotherapy. A search and narrative review of prospective clinical trials relating to neurological toxicity outcomes was conducted. Neurological toxicities can be challenging to diagnose and manage and should be considered during consideration of radiotherapy in brain metastasis, hence more emphasis should be placed on prevention and upfront mitigation of these complications, with novel strategies showing promising results in prospective trials being adopted into clinical practice.
Sections du résumé
OBJECTIVE
OBJECTIVE
This review will focus on the late neurological complications from cranial irradiation and relevant mitigation strategies.
BACKGROUND
BACKGROUND
Radiotherapy (RT) remains an important pillar in the management of brain metastases. Patients being treated in the modern era do experience longer survival, because of superior intra- and extra-cranial disease control. As a result, they can be more prone to developing and manifesting late complications post-brain radiotherapy.
METHODS
METHODS
A search and narrative review of prospective clinical trials relating to neurological toxicity outcomes was conducted.
CONCLUSIONS
CONCLUSIONS
Neurological toxicities can be challenging to diagnose and manage and should be considered during consideration of radiotherapy in brain metastasis, hence more emphasis should be placed on prevention and upfront mitigation of these complications, with novel strategies showing promising results in prospective trials being adopted into clinical practice.
Identifiants
pubmed: 35400164
doi: 10.21037/cco-21-121
pii: cco-21-121
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM