Literature review of management of brain metastases from germ cell tumors.

Brain Neoplasms / pathology Cranial Irradiation Humans Male Neoplasms, Germ Cell and Embryonal / surgery Prospective Studies Radiosurgery Testicular Neoplasms / surgery
Germ cell tumor brain metastases chemotherapy radiation therapy surgery

Journal

Chinese clinical oncology
ISSN: 2304-3873
Titre abrégé: Chin Clin Oncol
Pays: China
ID NLM: 101608375

Informations de publication

Date de publication:
Apr 2022
Historique:
received: 17 09 2021
accepted: 23 03 2022
pubmed: 12 4 2022
medline: 12 5 2022
entrez: 11 4 2022
Statut: ppublish

Résumé

In this review article, we discuss the role of chemotherapy, surgery, and radiation therapy in the treatment of brain metastases from germ cell tumors (GCT). GCT rarely metastasize to the brain and there is limited data to guide management. Most instances of brain metastases occur in patients with non-seminomatous germ cell tumors (NSGCT). We searched PubMed using the terms 'central nervous system (CNS) metastases' or 'brain metastases' and 'germ cell' from 2011 through August 2021. Review articles and prospective trials related to the treatment of brain metastases in GCT were included in addition to articles obtained by hand search of the references and clinical practice guidelines. We highlight the importance of using chemotherapy as first-line therapy in most situations. We discuss the very minimal data regarding surgery and its primary role when there is significant mass effect or brain shift. We also compare whole brain radiation therapy (WBRT) with the use of radiosurgery. We then provide overall recommendations based on the reviewed data and our experience as a referral center for GCT.

Sections du résumé

OBJECTIVE OBJECTIVE
In this review article, we discuss the role of chemotherapy, surgery, and radiation therapy in the treatment of brain metastases from germ cell tumors (GCT).
BACKGROUND BACKGROUND
GCT rarely metastasize to the brain and there is limited data to guide management. Most instances of brain metastases occur in patients with non-seminomatous germ cell tumors (NSGCT).
METHODS METHODS
We searched PubMed using the terms 'central nervous system (CNS) metastases' or 'brain metastases' and 'germ cell' from 2011 through August 2021. Review articles and prospective trials related to the treatment of brain metastases in GCT were included in addition to articles obtained by hand search of the references and clinical practice guidelines.
CONCLUSIONS CONCLUSIONS
We highlight the importance of using chemotherapy as first-line therapy in most situations. We discuss the very minimal data regarding surgery and its primary role when there is significant mass effect or brain shift. We also compare whole brain radiation therapy (WBRT) with the use of radiosurgery. We then provide overall recommendations based on the reviewed data and our experience as a referral center for GCT.

Identifiants

DOI: 10.21037/cco-21-127 PMID: 35400165
pubmed: 35400165
doi: 10.21037/cco-21-127
pii: cco-21-127
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

14

Auteurs

Amy Le (A)

Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN, USA.

Mona Arbab (M)

Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN, USA.

Nabil Adra (N)

Department of Hematology/Oncology, Indiana University School of Medicine, Indianapolis, IN, USA.

James C Miller (JC)

Department of Neurological Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.

Gordon A Watson (GA)

Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN, USA.

Kevin Shiue (K)

Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN, USA.

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Classifications MeSH

questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Tumeurs du cerveau › Literature review of management of brain...
questionsmedicales.fr › Thérapeutique › Radiothérapie › Irradiation crânienne › Literature review of management of brain...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Literature review of management of brain...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs embryonnaires et germinales › Literature review of management of brain...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Literature review of management of brain...
questionsmedicales.fr › Techniques d'investigation › Techniques stéréotaxiques › Radiochirurgie › Literature review of management of brain...
questionsmedicales.fr › Maladies endocriniennes › Troubles gonadiques › Maladies testiculaires › Tumeurs du testicule › Literature review of management of brain...