Tobacco Exposure During Pregnancy and Infections in Infants up to 1 Year of Age: The Japan Environment and Children's Study.
child
cohort study
infection
pregnancy
tobacco exposure
Journal
Journal of epidemiology
ISSN: 1349-9092
Titre abrégé: J Epidemiol
Pays: Japan
ID NLM: 9607688
Informations de publication
Date de publication:
05 10 2023
05 10 2023
Historique:
medline:
6
10
2023
pubmed:
12
4
2022
entrez:
11
4
2022
Statut:
ppublish
Résumé
Tobacco exposure during pregnancy is associated with several adverse outcomes in infants. We investigated the association between tobacco exposure during pregnancy (both active and second-hand) and various infections in infants up to 1 year. This prospective cohort study used a fixed dataset (jecs-an-20180131) from the Japan Environment and Children's Study of registered births in Japan during 2011-2014 that included 104,065 fetal records from enrolled pregnant women. Based on the participants' responses to the questionnaire on smoking status, mothers were first divided into "never smoked," "quit smoking," and "current smoker" groups and then into "no second-hand smoking (SHS)" and "SHS" groups. Infectious diseases included central nervous system infection, otitis media (OM), upper respiratory tract infection (URTI), lower respiratory tract infection (LRTI), gastroenteritis (GI), and urinary tract infection. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were calculated using logistic regression analysis and adjusted for maternal, socioeconomic, and postnatal confounding factors. Among the 73,205 newborns enrolled, multivariable analysis revealed that the aOR of LRTI and GI was 1.20 (95% CI, 1.07-1.33) and 1.18 (95% CI, 1.04-1.35), respectively, for the "current smoker with/without SHS" group compared with the "never smoked without SHS" group. "Quit smoking without SHS" was not associated with the risk of LRTI. SHS was associated with an increased risk of OM, URTI, LRTI, and GI, especially with LRTI and GI. Exposure to tobacco smoke during pregnancy was associated with an increased risk of OM, URTI, LRTI, and GI in infants during their first year of life.
Sections du résumé
BACKGROUND
Tobacco exposure during pregnancy is associated with several adverse outcomes in infants. We investigated the association between tobacco exposure during pregnancy (both active and second-hand) and various infections in infants up to 1 year.
METHODS
This prospective cohort study used a fixed dataset (jecs-an-20180131) from the Japan Environment and Children's Study of registered births in Japan during 2011-2014 that included 104,065 fetal records from enrolled pregnant women. Based on the participants' responses to the questionnaire on smoking status, mothers were first divided into "never smoked," "quit smoking," and "current smoker" groups and then into "no second-hand smoking (SHS)" and "SHS" groups. Infectious diseases included central nervous system infection, otitis media (OM), upper respiratory tract infection (URTI), lower respiratory tract infection (LRTI), gastroenteritis (GI), and urinary tract infection. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were calculated using logistic regression analysis and adjusted for maternal, socioeconomic, and postnatal confounding factors.
RESULTS
Among the 73,205 newborns enrolled, multivariable analysis revealed that the aOR of LRTI and GI was 1.20 (95% CI, 1.07-1.33) and 1.18 (95% CI, 1.04-1.35), respectively, for the "current smoker with/without SHS" group compared with the "never smoked without SHS" group. "Quit smoking without SHS" was not associated with the risk of LRTI. SHS was associated with an increased risk of OM, URTI, LRTI, and GI, especially with LRTI and GI.
CONCLUSION
Exposure to tobacco smoke during pregnancy was associated with an increased risk of OM, URTI, LRTI, and GI in infants during their first year of life.
Identifiants
pubmed: 35400710
doi: 10.2188/jea.JE20210405
pmc: PMC10483106
doi:
Substances chimiques
Tobacco Smoke Pollution
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
489-497Références
Int J Epidemiol. 2004 Aug;33(4):816-20
pubmed: 15166194
Lancet Glob Health. 2018 Jul;6(7):e769-e776
pubmed: 29859815
Lancet. 2011 Jan 8;377(9760):139-46
pubmed: 21112082
Clin Investig. 1994 Feb;72(3):225-32
pubmed: 8012167
Am J Epidemiol. 2007 Sep 15;166(6):679-86
pubmed: 17625224
NPJ Prim Care Respir Med. 2016 Nov 17;26:16067
pubmed: 27853176
Clin Pediatr (Phila). 2009 Sep;48(7):756-62
pubmed: 19411611
Respir Res. 2006 Mar 28;7:48
pubmed: 16569224
Pediatr Infect Dis J. 2013 Jan;32(1):e1-7
pubmed: 22929173
Arch Pediatr Adolesc Med. 2012 Jan;166(1):18-27
pubmed: 21893640
Eur J Epidemiol. 2008;23(8):547-55
pubmed: 18553141
Am J Respir Crit Care Med. 2005 Jan 1;171(1):78-82
pubmed: 15502114
Thorax. 1997 Oct;52(10):905-14
pubmed: 9404380
Sci Rep. 2016 Apr 22;6:23907
pubmed: 27103591
Am J Public Health. 1999 May;89(5):712-7
pubmed: 10224983
Thorax. 1994 Aug;49(8):825-34
pubmed: 8091331
Respir Res. 2011 Jan 10;12:5
pubmed: 21219618
Thorax. 1999 Apr;54(4):357-66
pubmed: 10092699
Lancet. 2012 Dec 15;380(9859):2095-128
pubmed: 23245604
Sci Rep. 2015 Aug 13;5:13020
pubmed: 26268789
Pediatrics. 1999 Jan;103(1):E3
pubmed: 9917483
Epidemiol Infect. 2014 Feb;142(2):371-8
pubmed: 23659618
Birth Defects Res A Clin Mol Teratol. 2016 Jul;106(7):596-603
pubmed: 27040999
Pediatr Res. 2007 Apr;61(4):462-6
pubmed: 17515872
Fukushima J Med Sci. 2017 Dec 19;63(3):127-134
pubmed: 28867684
J Clin Epidemiol. 1996 Apr;49(4):449-54
pubmed: 8621996
Eur Respir J. 2015 Sep;46(3):697-706
pubmed: 26022951
Lancet. 2014 May 3;383(9928):1549-60
pubmed: 24680633
J Allergy Clin Immunol. 2007 Aug;120(2):445-51
pubmed: 17482667
Kansenshogaku Zasshi. 1999 Sep;73(9):901-8
pubmed: 10535265
Pediatrics. 2004 Apr;113(4 Suppl):1007-15
pubmed: 15060193
Prev Med. 2016 Aug;89:278-285
pubmed: 27283094
Pediatr Infect Dis J. 2006 Dec;25(12):1123-31
pubmed: 17133157
Eur Respir J. 2006 Oct;28(4):721-9
pubmed: 16870663
J Epidemiol. 2018 Feb 5;28(2):99-104
pubmed: 29093304
Pediatrics. 2008 Feb;121(2):244-52
pubmed: 18245414
BMC Public Health. 2014 Jan 10;14:25
pubmed: 24410977
Int J Epidemiol. 1997 Jun;26(3):571-4
pubmed: 9222782
PLoS Med. 2010 Dec 07;7(12):e1000374
pubmed: 21151890
Thorax. 2000 Apr;55(4):271-6
pubmed: 10722765