Induction of mucosal healing by intensive granulocyte/monocyte adsorptive apheresis (GMA) without use of corticosteroids in patients with ulcerative colitis: long-term remission maintenance after induction by GMA and efficacy of GMA re-treatment upon relapse.
intensive GMA
re-treatment
remission maintenance
ulcerative colitis
Journal
Journal of clinical biochemistry and nutrition
ISSN: 0912-0009
Titre abrégé: J Clin Biochem Nutr
Pays: Japan
ID NLM: 8700907
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
14
08
2021
accepted:
20
10
2021
entrez:
11
4
2022
pubmed:
12
4
2022
medline:
12
4
2022
Statut:
ppublish
Résumé
This study examined the long-term maintenance rate after inducing remission by intensive granulocyte/monocyte adsorptive apheresis (GMA) without use of corticosteroids (CS) and GMA re-treatment efficacy in the same patients upon relapse with ulcerative colitis. Patients who achieved clinical remission and mucosal healing (MH) by first-time intensive GMA (first GMA) without CS were enrolled. The cumulative non-relapse survival rate up to week 156 was calculated. Patients with relapse during the maintenance period underwent second-time intensive GMA (second GMA) without CS. Clinical remission and MH rates following second GMA were compared to those following first GMA in the same patients. Of the 84 patients enrolled, 78 were followed until week 156 and 34 demonstrated relapse. The cumulative non-relapse survival rate by week 156 was 56.4%. Clinical remission and MH rates after second GMA did not differ from those after first GMA in the same patients (week 6: clinical remission, 100% vs 88.4%,
Identifiants
pubmed: 35400813
doi: 10.3164/jcbn.21-112
pii: DN/JST.JSTAGE/jcbn/21-112
pmc: PMC8921725
doi:
Types de publication
Journal Article
Langues
eng
Pagination
197-204Informations de copyright
Copyright © 2022 JCBN.
Déclaration de conflit d'intérêts
SI received scholarship donations from Takeda Pharmaceutical Co., Ltd. and Nippon Kayaku Co., Ltd., and lecture fees from Takeda Pharmaceutical Co., Ltd., and Abbvie GK. KS received a lecture fee from AstraZeneca plc.
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