Delayed Graft Function Under the Microscope: Surveillance Biopsies in Kidney Transplantation.
acute rejection
delayed graft function
immunosuppression
renal biopsy
renal transplantation
Journal
Transplant international : official journal of the European Society for Organ Transplantation
ISSN: 1432-2277
Titre abrégé: Transpl Int
Pays: Switzerland
ID NLM: 8908516
Informations de publication
Date de publication:
2022
2022
Historique:
received:
06
01
2022
accepted:
24
02
2022
entrez:
11
4
2022
pubmed:
12
4
2022
medline:
13
4
2022
Statut:
epublish
Résumé
Delayed graft function (DGF) is a common complication of kidney transplantation and frequently leads to the necessity of surveillance biopsies. The purpose of this study is to describe the histological findings in surveillance biopsies of deceased donor kidney transplant recipients and evaluate the risk factors for graft outcomes. This is a monocentric, retrospective study including kidney transplant recipients that underwent a graft biopsy during the DGF period between January 2006 and July 2019. 356 biopsies were performed in 335 deceased donor transplant recipients. Biopsies were analyzed according to the Banff classification. The main histological findings were: acute tubular necrosis in 150 biopsies (42.1%), acute rejection in 96 biopsies (26.9%), and borderline findings in 91 biopsies (25.5%). In the multivariate analysis, recipient age (
Identifiants
pubmed: 35401043
doi: 10.3389/ti.2022.10344
pii: 10344
pmc: PMC8988887
doi:
Substances chimiques
Antibodies
0
Antilymphocyte Serum
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
10344Informations de copyright
Copyright © 2022 Castro Filho, Pompeo, Machado, Gonçalves, Bauer and Manfro.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
N Engl J Med. 2007 Dec 20;357(25):2562-75
pubmed: 18094377
Nephrol Dial Transplant. 2014 Jun;29(6):1134-40
pubmed: 24335382
Lancet. 2004 Nov 13-19;364(9447):1814-27
pubmed: 15541456
Am J Transplant. 2013 Apr;13(4):993-1000
pubmed: 23406284
PLoS One. 2015 Dec 17;10(12):e0144188
pubmed: 26679933
Transplant Proc. 2009 Jan-Feb;41(1):133-4
pubmed: 19249497
Am J Transplant. 2012 Jan;12(1):191-201
pubmed: 21992503
Exp Clin Transplant. 2020 Feb;18(1):13-18
pubmed: 31266437
Transplantation. 2017 Apr;101(4):867-872
pubmed: 27495758
J Immunol. 2010 Mar 1;184(5):2518-27
pubmed: 20100933
Am J Transplant. 2011 Nov;11(11):2279-96
pubmed: 21929642
Transplantation. 2007 Dec 27;84(12):1618-24
pubmed: 18165773
J Nephrol. 2017 Dec;30(6):859-868
pubmed: 27686224
Nephrol Dial Transplant. 2009 Mar;24(3):1039-47
pubmed: 19103734
EBioMedicine. 2018 Feb;28:31-42
pubmed: 29398595
Am J Transplant. 2015 Nov;15(11):2900-7
pubmed: 26484837
Transpl Immunol. 2002 Aug;10(2-3):125-32
pubmed: 12216942
Kidney Int. 2015 Aug;88(2):241-9
pubmed: 25786101
PLoS One. 2018 Jun 21;13(6):e0199445
pubmed: 29928026
J Bras Nefrol. 2013 Oct-Dec;35(4):289-98
pubmed: 24402109
J Bras Nefrol. 2019 Apr-Jun;41(2):231-241
pubmed: 30300438
Transplantation. 2019 Feb;103(2):412-419
pubmed: 29762458
N Engl J Med. 1999 Dec 2;341(23):1725-30
pubmed: 10580071
Exp Clin Transplant. 2013 Aug;11(4):310-4
pubmed: 23121641
Transpl Int. 2021 Jan;34(1):175-184
pubmed: 33131120
Transplantation. 2008 Apr 15;85(7 Suppl):S3-9
pubmed: 18401260
Clin Transplant. 2018 Mar;32(3):e13190
pubmed: 29314286
Transplantation. 2002 Nov 15;74(9):1281-6
pubmed: 12451266
Transplantation. 2013 Nov 27;96(10):885-9
pubmed: 24056620
Kidney Int. 2010 Feb;77(4):299-311
pubmed: 19847156
Am J Transplant. 2010 Oct;10(10):2279-86
pubmed: 20883559
Am J Kidney Dis. 2013 Nov;62(5):953-73
pubmed: 23725972
Clin J Am Soc Nephrol. 2020 Oct 7;15(10):1484-1493
pubmed: 32778537
Am J Transplant. 2011 Dec;11(12):2657-64
pubmed: 22051325
ISRN Nephrol. 2014 Mar 05;2014:292305
pubmed: 24967241
Am J Kidney Dis. 2010 Aug;56(2):189-218
pubmed: 20598411
Kidney Int. 2015 Oct;88(4):851-8
pubmed: 26108067
Chin Med J (Engl). 2020 Mar 5;133(5):561-570
pubmed: 32053570
Am J Transplant. 2003;3 Suppl 4:114-25
pubmed: 12694055
Transpl Int. 2021 Jun;34(6):1093-1104
pubmed: 33742470
Am J Transplant. 2019 Aug;19(8):2252-2261
pubmed: 30838775