Therapeutic Targeting of Endosome and Mitochondrial Reactive Oxygen Species Protects Mice From Influenza Virus Morbidity.
NADPH oxidase
airway inflammation
endosome
inflammation
influenza A virus
lung inflammation
mitochondria
reactive oxygen
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2022
2022
Historique:
received:
06
02
2022
accepted:
02
03
2022
entrez:
11
4
2022
pubmed:
12
4
2022
medline:
12
4
2022
Statut:
epublish
Résumé
There is an urgent need to develop effective therapeutic strategies including immunomodulators to combat influenza A virus (IAV) infection. Influenza A viruses increase ROS production, which suppress anti-viral responses and contribute to pathological inflammation and morbidity. Two major cellular sites of ROS production are endosomes
Identifiants
pubmed: 35401240
doi: 10.3389/fphar.2022.870156
pii: 870156
pmc: PMC8984148
doi:
Types de publication
Journal Article
Langues
eng
Pagination
870156Informations de copyright
Copyright © 2022 To, Erlich, Liong, Liong, Luong, Oseghale, Miles, Papagianis, Quinn, Bozinovski, Vlahos, Brooks, O’Leary, Brooks and Selemidis.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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