Genotypes of Pain and Analgesia in a Randomized Trial of Irritable Bowel Syndrome.
genome-wide association study
genotype
irritable bowel syndrome
pain
randomized controlled trial
Journal
Frontiers in psychiatry
ISSN: 1664-0640
Titre abrégé: Front Psychiatry
Pays: Switzerland
ID NLM: 101545006
Informations de publication
Date de publication:
2022
2022
Historique:
received:
23
12
2021
accepted:
22
02
2022
entrez:
11
4
2022
pubmed:
12
4
2022
medline:
12
4
2022
Statut:
epublish
Résumé
Irritable bowel syndrome (IBS) is a highly prevalent chronic pain disorder with multiple underlying mechanisms and few treatments that have been demonstrated to be effective in placebo controlled trials. One potential reason may be the use of composite outcomes, such as the IBS Symptom Severity Scale (IBS-SSS) which includes descriptive items related to pain frequency and pain intensity as well as bowel dysfunction and bloating. We investigated if different features of IBS pain have distinct genetic associations and if these may be moderated by sex hormones. Adult outpatients with moderately severe IBS (>175 on IBS-SSS) enrolled in a clinical trial reported IBS-SSS at baseline and after 6 weeks of therapy. Fixed effects modeling was used to test the effect of A total of 212 participants (74% female) were included. The Previously reported association between
Sections du résumé
Background
UNASSIGNED
Irritable bowel syndrome (IBS) is a highly prevalent chronic pain disorder with multiple underlying mechanisms and few treatments that have been demonstrated to be effective in placebo controlled trials. One potential reason may be the use of composite outcomes, such as the IBS Symptom Severity Scale (IBS-SSS) which includes descriptive items related to pain frequency and pain intensity as well as bowel dysfunction and bloating. We investigated if different features of IBS pain have distinct genetic associations and if these may be moderated by sex hormones.
Participants and Setting
UNASSIGNED
Adult outpatients with moderately severe IBS (>175 on IBS-SSS) enrolled in a clinical trial reported IBS-SSS at baseline and after 6 weeks of therapy.
Methods
UNASSIGNED
Fixed effects modeling was used to test the effect of
Results
UNASSIGNED
A total of 212 participants (74% female) were included. The
Conclusions
UNASSIGNED
Previously reported association between
Identifiants
pubmed: 35401282
doi: 10.3389/fpsyt.2022.842030
pmc: PMC8983929
doi:
Types de publication
Journal Article
Langues
eng
Pagination
842030Subventions
Organisme : NHLBI NIH HHS
ID : K01 HL130625
Pays : United States
Organisme : NIDDK NIH HHS
ID : K23 DK119584
Pays : United States
Informations de copyright
Copyright © 2022 Vollert, Wang, Regis, Yetman, Lembo, Kaptchuk, Cheng, Nee, Iturrino, Loscalzo, Hall and Silvester.
Déclaration de conflit d'intérêts
AL owns stock in Bristol Myer Squibb and Johnson & Johnson and receives income from Vibrant and Mylan. JL is the scientific co-founder of Scipher Medicine, Inc. JN consults for World Clinical Care. JS has received consultancy fees from Alimentiv, Mozart Therapeutics, Takeda Pharmaceuticals, and Teva Pharmaceuticals. JV has received consultancy fees from Vertex Pharmaceuticals and Embody Orthopedics outside the submitted work. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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